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Keywords = simple partial status epilepticus

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15 pages, 3251 KB  
Article
Electroacupuncture Reduces Seizure Activity and Enhances GAD 67 and Glutamate Transporter Expression in Kainic Acid Induced Status Epilepticus in Infant Rats
by Angelica Vega-García, Teresa Neri-Gómez, Vinnitsa Buzoianu-Anguiano, Christian Guerra-Araiza, Julia Segura-Uribe, Iris Feria-Romero and Sandra Orozco-Suarez
Behav. Sci. 2019, 9(7), 68; https://doi.org/10.3390/bs9070068 - 27 Jun 2019
Cited by 3 | Viewed by 5205
Abstract
Status epilepticus (SE) is one of the most significant complications in pediatric neurology. Clinical studies have shown positive effects of electroacupuncture (EA) as a therapeutic alternative in the control of partial seizures and secondary generalized clonic seizures. EA promotes the release of neurotransmitters [...] Read more.
Status epilepticus (SE) is one of the most significant complications in pediatric neurology. Clinical studies have shown positive effects of electroacupuncture (EA) as a therapeutic alternative in the control of partial seizures and secondary generalized clonic seizures. EA promotes the release of neurotransmitters such as GABA and some opioids. The present study aimed to evaluate the anticonvulsive and neuromodulatory effects of Shui Gou DM26 (SG_DM26) acupuncture point electrostimulation on the expression of the glutamate decarboxylase 67 (GAD67) enzyme and the glutamate transporter EAAC1 in an early SE model. At ten postnatal days (10-PD), male rats weighing 22–26 g were divided into 16 groups, including control and treatment groups: Simple stimulation, electrostimulation, anticonvulsant drug treatment, and combined treatment—electrostimulation and pentobarbital (PB). SE was induced with kainic acid (KA), and the following parameters were measured: Motor behavior, and expression of GAD67 and EAAC1. The results suggest an antiepileptic effect derived from SG DM26 point EA. The possible mechanism is most likely the increased production of the inhibitory neurotransmitter GABA, which is observed as an increase in the expression of both GAD67 and EAAC1, as well as the potential synergy between the neuromodulator effects of EA and PB. Full article
(This article belongs to the Special Issue From Basic to Clinical in Behavioral Disorders)
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3 pages, 792 KB  
Case Report
Simple Partial Status Epilepticus Manifested as Homonymous Hemianopsia: A Rare Intracranial Recording
by Anna Siatouni, Stylianos Gatzonis, Andreas Alexopoulos, Nikos Georgakoulias, Mathildi Papathanassiou, Stefanos Korfias, Vaso Zisimopoulou and Damianos Sakas
Clin. Pract. 2016, 6(1), 840; https://doi.org/10.4081/cp.2016.840 - 31 Mar 2016
Cited by 4 | Viewed by 851
Abstract
A 30-year-old woman with intractable seizures evaluated as surgical candidate. During presurgical evaluation an invasive electroencephalogram was recommended to define the location and extent of epileptogenic zone and relationship to epileptogenic lesion. On third monitoring night the patient complained of persistent homonymous hemianopsia [...] Read more.
A 30-year-old woman with intractable seizures evaluated as surgical candidate. During presurgical evaluation an invasive electroencephalogram was recommended to define the location and extent of epileptogenic zone and relationship to epileptogenic lesion. On third monitoring night the patient complained of persistent homonymous hemianopsia following a habitual seizure. Concurrently, persistent epileptic activity was evident in a small, restricted area around the right calcarine fissure. The ictal discharges persisted for the next 30 h despite high-dose administration of intravenous antiepileptic drugs, until patient was taken to operating room. Simple partial status epilepticus presenting with pure visual symptoms is rare and difficult to diagnose, even more so when presenting with negative visual phenomena. Epileptic etiology of unexplained, paroxysmal negative visual symptoms should be considered in the differential diagnosis in patients with pre-existing epilepsy, as well as patients with no prior history of epilepsy. Full article
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