Search Results (8)

The Zhag Cave in western Tibet, dated to the 11th to 12th centuries, features four walls fully adorned with images of the Thousand Buddhas of the Bhadrakalpa (Fortunate Aeon). According to the Tibetan inscriptions, the arrangement of the Thousand Buddhas creates a circumambulatory space for worship and confession, enabling practitioners to purify their sins. Four aspects of the Zhag Cave are comparable to those of Dunhuang. First, among the inscriptions is the Pratītyasamutpāda-gāthā, elaborated in the Śālistamba Sūtra, the Tibetan manuscripts of which have been unearthed in both western Tibet and Dunhuang. Second, the way of depicting Thousand Buddhas on four walls inside the cave could be found in earlier caves from the 5th to 6th centuries at Dunhuang. Third, the specific practice of only depicting the Bhadrakalpa Thousand Buddhas on the walls parallels similar caves from the mid-10th to early 13th centuries at Dunhuang. Fourth, the motifs depicted along the wall edges correspond with the prevalent themes found in the Bhadrakalpa Thousand Buddhas transformation tableaux during the 9th to 13th centuries, reflecting the apogee of Bhadrakalpa Thousand Buddhas devotion. These connections prompt us to think about the ways in which Western Tibet was part of the Silk Road network. I argue that this shared iconographic and ritual framework embodies the intertwined religious practices of the Dharma-ending Age (Mofa 末法) thought and Buddhist revival movements along the Silk Road, explaining these complex interconnections between the Zhag Cave and the Dunhuang relics within the broader context of religious beliefs and socio-cultural patterns. Full article

Since the mid-19th century, researchers have explored the potential of bio-based polymeric materials for diverse applications, with particular promise in medicine. This review provides a focused and detailed examination of natural and synthetic biopolymers relevant to tissue engineering and biomedical applications. It emphasizes the structural diversity, functional characteristics, and processing strategies of major classes of biopolymers, including polysaccharides (e.g., hyaluronic acid, alginate, chitosan, bacterial cellulose) and proteins (e.g., collagen, silk fibroin, albumin), as well as synthetic biodegradable polymers such as polycaprolactone, polylactic acid, and polyhydroxybutyrate. The central aim of this manuscript is to elucidate how intrinsic properties—such as molecular weight, crystallinity, water retention, and bioactivity—affect the performance of biopolymers in biomedical contexts, particularly in drug delivery, wound healing, and scaffold-based tissue regeneration. This review also highlights recent advancements in polymer functionalization, composite formation, and fabrication techniques (e.g., electrospinning, bioprinting), which have expanded the application potential of these materials. By offering a comparative analysis of structure–property–function relationships across a diverse range of biopolymers, this review provides a comprehensive reference for selecting and engineering materials tailored to specific biomedical challenges. It also identifies key limitations, such as production scalability and mechanical performance, and suggests future directions for developing clinically viable and environmentally sustainable biomaterial platforms. Full article

Synthetic and natural fibers are widely used in the textile industry. Natural fibers include cellulose-based materials like cotton, and regenerated fibers like viscose as well as protein-based fibers such as silk and wool. Synthetic fibers, on the other hand, include PET and polyamides (like nylon). Due to significant differences in their chemistry, distinct dyeing processes are required, each generating specific waste. For example, cellulose fibers exhibit chemical inertness toward dyes, necessitating chemical auxiliaries that contribute to wastewater contamination, whereas synthetic fibers are a major source of non-biodegradable microplastic emissions. Addressing the environmental impact of fiber processing requires a deep molecular-level understanding to enable informed decision-making. This manuscript emphasizes potential solutions, particularly through the biodegradation of textile materials and related chemical waste, aligning with the United Nations Sustainable Development Goal 6, which promotes clean water and sanitation. For instance, cost-effective methods using enzymes or microbes can aid in processing the fibers and their associated dyeing solutions while also addressing textile wastewater, which contains high concentrations of unreacted dyes, salts, and other highly water-soluble pollutants. This paper covers different aspects of fiber chemistry, dyeing, degradation mechanisms, and the chemical waste produced by the textile industry, while highlighting microbial-based strategies for waste mitigation. The integration of microbes not only offers a solution for managing large volumes of textile waste but also paves the way for sustainable technologies. Full article

Developing drug delivery systems to target cytotoxic drugs directly into tumor cells is still a compelling need with regard to reducing side effects and improving the efficacy of cancer chemotherapy. In this work, silk fibroin nanoparticles (SFNs) have been designed to load a previously described cytotoxic compound (NDI-1) that disrupts the cell cycle by specifically interacting with non-canonical secondary structures of DNA. SFNs were then functionalized on their surface with cyclic pentapeptides incorporating the Arg-Gly-Asp sequence (cRGDs) to provide active targeting toward glioma cell lines that abundantly express ανβ3 and ανβ5 integrin receptors. Cytotoxicity and selective targeting were assessed by in vitro tests on human glioma cell lines U373 (highly-expressing integrin subunits) and D384 cell lines (low-expressing integrin subunits in comparison to U373). SFNs were of nanometric size (d₅₀ less than 100 nm), round shaped with a smooth surface, and with a negative surface charge; overall, these characteristics made them very likely to be taken up by cells. The active NDI-1 was loaded into SFNs with high encapsulation efficiency and was not released before the internalization and degradation by cells. Functionalization with cRGDs provided selectivity in cell uptake and thus cytotoxicity, with a significantly higher cytotoxic effect of NDI-1 delivered by cRGD-SFNs on U373 cells than on D384 cells. This manuscript provides an in vitro proof-of-concept of cRGD-silk fibroin nanoparticles’ active site-specific targeting of tumors, paving the way for further in vivo efficacy tests. Full article

The present manuscript describes the use of silk cocoons as a structuring agent for the formation of an iron-based active phase for the controlled oxidation of benzyl alcohol. Different samples were prepared using different calcination temperatures. X-ray diffraction and transmission electron microscopy showed a higher proportion of alpha-Fe₂O₃ phase and a higher global crystallinity at superior calcination temperature. In terms of catalytic activity, the sample treated at 500 °C presented the highest conversion reaching 47%, with selectivity in benzaldehyde of 75.9%. Full article

Nowadays, cancer represents a major public health issue, a substantial economic issue, and a burden for society. Limited by numerous disadvantages, conventional chemotherapy is being replaced by new strategies targeting tumor cells. In this context, therapies based on biopolymer prodrug systems represent a promising alternative for improving the pharmacokinetic and pharmacologic properties of drugs and reducing their toxicity. The polymer-directed enzyme prodrug therapy is based on tumor cell targeting and release of the drug using polymer–drug and polymer–enzyme conjugates. In addition, current trends are oriented towards natural sources. They are biocompatible, biodegradable, and represent a valuable and renewable source. Therefore, numerous antitumor molecules have been conjugated with natural polymers. The present manuscript highlights the latest research focused on polymer–drug conjugates containing natural polymers such as chitosan, hyaluronic acid, dextran, pullulan, silk fibroin, heparin, and polysaccharides from Auricularia auricula. Full article

This study investigated traditional conservation and storage methods for Chinese silk manuscripts containing painting and calligraphy from the Warring States period (475–221 BC), the Qin dynasty (221–207 BC), the Han dynasty (202–8 BC; AD 25–220), and from the end of the Han to the present. At present, there is gap in the literature regarding the application of such methods to these works. The study methods include a literature review (classical and contemporary sources), expert interviews, and observation of traditional masters. The findings provide an improved understanding of the development of traditional technologies used for painting and calligraphy conservation since 475 BC. In this way, this work contributes to the body of knowledge regarding traditional conservation and storage methods, including mounting practices, scroll unfolding, and box storage. Full article

The aim of this paper is to present the results of research undertaken on a wooden box that holds an important historical book: a hand Bible handwritten in the thirteenth century. Tradition connects this Bible to the name of Marco Polo (Venice, 1254–1324), who was supposedly the owner—the book possibly accompanied him on his travels (1262 and 1271) to China. The Bible is of fine workmanship and written on thin parchment, and its container—along with a yellow silk cloth—are preserved in the ancient and prestigious Laurentian Library in Florence. The manuscript was in very poor condition and was being restored during the period of study (2011). Surveys were carried out to determine the place and period of manufacture of the box, and to determine if it was contemporary to or later than the manuscript it contained or whether it was made in China or Europe. An additional aim of the work was to demonstrate that a fast and inexpensive in situ survey under imperfect time and space conditions was possible using in-depth observation and simple tools as well as a portable microscope, all performed without sampling. During the restoration process, a team of experts used instruments helpful in determining the chemical composition of the paper and related ink. Other specialists studied the paleography of the text. The results indicate that the Bible is definitely from the same period as Marco Polo. Nothing excludes the possibility that Marco Polo may have seen it or lived not too far from this manuscript, which traveled in a small wooden box, wrapped in a precious yellow silk cloth. Full article