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Keywords = pyrano acridine

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9 pages, 422 KB  
Proceeding Paper
Microwave Assisted Synthesis and Its Cytotoxicity Study of 4H-Pyrano[2,3-a]acridine-3-carbonitrile Intermediate: Experiment Design for Optimization Using Response Surface Methodology
by Selvaraj Mohana Roopan, Annadurai Bharathi and Duraipandi Devi Priya
Proceedings 2019, 41(1), 12; https://doi.org/10.3390/ecsoc-23-06594 - 14 Nov 2019
Cited by 1 | Viewed by 1286
Abstract
Several synthetic routes have been achieved to synthesize pyrane fused systems. As a follow up of earlier work, we hereby report the microwave assisted synthesis of key intermediate, pyrane fused acridine compounds 3af. It was obtained by treating α,β-unsaturated ketone [...] Read more.
Several synthetic routes have been achieved to synthesize pyrane fused systems. As a follow up of earlier work, we hereby report the microwave assisted synthesis of key intermediate, pyrane fused acridine compounds 3af. It was obtained by treating α,β-unsaturated ketone 1af and malononitrile 2 in presence of piperidine with ethanolic solution at 50 C under 200 W power. This method also optimized via microwave method using RSM methodology. All the synthesized derivatives and target compounds were evaluated for cytotoxicity effect on human hepatoblastoma (HepG2) cell line and HDAC enzyme activity. Full article
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