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8 Results Found

  • Article
  • Open Access
4 Citations
2,614 Views
16 Pages

Development of the Latanoprost Solid Delivery System Based on Poly(l-lactide-co-glycolide-co-trimethylene carbonate) with Shape Memory for Glaucoma Treatment

  • Aleksandra Borecka,
  • Jakub Rech,
  • Henryk Janeczek,
  • Justyna Wilińska,
  • Janusz Kasperczyk,
  • Magdalena Kobielarz,
  • Paweł Grieb and
  • Artur Turek

27 June 2023

Latanoprost (LTP) is a prostaglandin F2α analog used to lower intraocular pressure in glaucoma treatment administered daily as eye drops. In this study, a universal model based on poly(l-lactide-co-glycolide-co-trimethylene carbonate) with shape memo...

  • Article
  • Open Access
3 Citations
2,905 Views
15 Pages

The Role of the Mechanical, Structural, and Thermal Properties of Poly(l-lactide-co-glycolide-co-trimethylene carbonate) in the Development of Rods with Aripiprazole

  • Artur Turek,
  • Jakub Rech,
  • Aleksandra Borecka,
  • Justyna Wilińska,
  • Magdalena Kobielarz,
  • Henryk Janeczek and
  • Janusz Kasperczyk

15 October 2021

In this work, we aimed to determine the role of the mechanical, structural, and thermal properties of poly(l-lactide-co-glycolide-co-trimethylene carbonate) (P(l-LA:GA:TMC)) with shape memory in the formulation of implantable and biodegradable rods w...

  • Correction
  • Open Access
967 Views
2 Pages

7 December 2023

In the original publication [...]

  • Article
  • Open Access
9 Citations
5,945 Views
15 Pages

10 August 2017

The presented paper concerns scientific research on processing a poly(lactide-co-glycolide-co-trimethylene carbonate) copolymer (PLLAGLTMC) with thermally induced shape memory and a transition temperature around human body temperature. The material i...

  • Article
  • Open Access
3 Citations
2,039 Views
19 Pages

Hot Melt Extrusion as a Formulation Method of Terpolymer Rods with Aripiprazole: A Preliminary Study

  • Justyna Wilińska,
  • Artur Turek,
  • Jakub Rech,
  • Henryk Janeczek,
  • Małgorzata Pastusiak,
  • Aleksandra Kordyka,
  • Aleksandra Borecka,
  • Magdalena Kobielarz and
  • Janusz Kasperczyk

23 August 2023

Aripiprazole (ARP) is an atypical neuroleptic used in the therapy of mental diseases such as schizophrenia. The lack of optimal adherence to an oral therapy regime creates the basis for designing ARP long-acting injections. This study aimed to use 10...

  • Feature Paper
  • Article
  • Open Access
16 Citations
8,248 Views
17 Pages

Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior

  • Piotr Rychter,
  • Natalia Śmigiel-Gac,
  • Elżbieta Pamuła,
  • Anna Smola-Dmochowska,
  • Henryk Janeczek,
  • Wojciech Prochwicz and
  • Piotr Dobrzyński

20 January 2016

The aim of the study was the evaluation of gamma irradiation and electron beams for sterilization of porous scaffolds with shape memory behavior obtained from biodegradable terpolymers: poly(l-lactide-co-glycolide-co-trimethylene carbonate) and poly(...

  • Article
  • Open Access
40 Citations
5,527 Views
15 Pages

Effect of Polymer Permeability and Solvent Removal Rate on In Situ Forming Implants: Drug Burst Release and Microstructure

  • Xiaowei Zhang,
  • Liqun Yang,
  • Chong Zhang,
  • Danhua Liu,
  • Shu Meng,
  • Wei Zhang and
  • Shengnan Meng

To explore the mechanism of drug release and depot formation of in situ forming implants (ISFIs), osthole-loaded ISFIs were prepared by dissolving polylactide, poly(lactide-co-glycolide), polycaprolactone, or poly(trimethylene carbonate) in different...

  • Article
  • Open Access
660 Views
27 Pages

27 October 2025

Finite element analysis (FEA) is common in biomedical engineering for combining design and material development, with model validation crucial for accurate prediction of material behavior. Simplified geometries are commonly needed in stent developmen...