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Keywords = poly(lactide-co-glycolide-co-trimethylene carbonate)

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2 pages, 171 KiB  
Correction
Correction: Borecka et al. Development of the Latanoprost Solid Delivery System Based on Poly(l-lactide-co-glycolide-co-trimethylene carbonate) with Shape Memory for Glaucoma Treatment. Appl. Sci. 2023, 13, 7562
by Aleksandra Borecka, Jakub Rech, Henryk Janeczek, Justyna Wilińska, Janusz Kasperczyk, Magdalena Kobielarz, Paweł Grieb and Artur Turek
Appl. Sci. 2023, 13(24), 13043; https://doi.org/10.3390/app132413043 - 7 Dec 2023
Viewed by 809
Abstract
In the original publication [...] Full article
(This article belongs to the Special Issue Advances in Biomaterials and Drug Technology)
19 pages, 28673 KiB  
Article
Hot Melt Extrusion as a Formulation Method of Terpolymer Rods with Aripiprazole: A Preliminary Study
by Justyna Wilińska, Artur Turek, Jakub Rech, Henryk Janeczek, Małgorzata Pastusiak, Aleksandra Kordyka, Aleksandra Borecka, Magdalena Kobielarz and Janusz Kasperczyk
Appl. Sci. 2023, 13(17), 9521; https://doi.org/10.3390/app13179521 - 23 Aug 2023
Cited by 2 | Viewed by 1629
Abstract
Aripiprazole (ARP) is an atypical neuroleptic used in the therapy of mental diseases such as schizophrenia. The lack of optimal adherence to an oral therapy regime creates the basis for designing ARP long-acting injections. This study aimed to use 105 °C hot melt [...] Read more.
Aripiprazole (ARP) is an atypical neuroleptic used in the therapy of mental diseases such as schizophrenia. The lack of optimal adherence to an oral therapy regime creates the basis for designing ARP long-acting injections. This study aimed to use 105 °C hot melt extrusion (HME) as a formulation method for rods based on poly(d,l-lactide-co-glycolide-co-trimethylene carbonate) with a molecular weight (Mn) of 21 kDa (Td,l 21), poly(l-lactide-co-glycolide-co-trimethylene carbonate) with a Mn of 59 kDa (Tl 59), and with a Mn of 77 kDa (Tl 77). The following methods were involved in the research: NMR, DSC, XRD, HSM, FTIR, GPC, SEM, and mechanical tests. HME at 105 °C (i) ensured flow behavior for terpolymers, (ii) did not influence the terpolymers’ composition and (iii) the polymorph changes of ARP, and (iv) resulted in the changes in terpolymers’ Mn. For the rods with ARP based on Td,l 21 (Td,l 21 rod-ARP) and Tl 59 (Tl 59 rod-ARP), plasticization was noted. No drug–terpolymer interactions were revealed. No pores were observed on the surface. Due to its high flexibility and rubber character, Td,l 21 rod-ARP may be proposed for intramuscular administration, whereas Tl 59 rod-ARP, due to its higher strength and moderate stiffness, is proposed for subcutaneous administration. Full article
(This article belongs to the Special Issue Advances in Biomaterials and Drug Technology)
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16 pages, 20405 KiB  
Article
Development of the Latanoprost Solid Delivery System Based on Poly(l-lactide-co-glycolide-co-trimethylene carbonate) with Shape Memory for Glaucoma Treatment
by Aleksandra Borecka, Jakub Rech, Henryk Janeczek, Justyna Wilińska, Janusz Kasperczyk, Magdalena Kobielarz, Paweł Grieb and Artur Turek
Appl. Sci. 2023, 13(13), 7562; https://doi.org/10.3390/app13137562 - 27 Jun 2023
Cited by 2 | Viewed by 2121 | Correction
Abstract
Latanoprost (LTP) is a prostaglandin F2α analog used to lower intraocular pressure in glaucoma treatment administered daily as eye drops. In this study, a universal model based on poly(l-lactide-co-glycolide-co-trimethylene carbonate) with shape memory was proposed for [...] Read more.
Latanoprost (LTP) is a prostaglandin F2α analog used to lower intraocular pressure in glaucoma treatment administered daily as eye drops. In this study, a universal model based on poly(l-lactide-co-glycolide-co-trimethylene carbonate) with shape memory was proposed for the development of a solid biodegradable formulation with prolonged release administered intraconjunctivally, intravitreally, subconjunctivally, and subcutaneously. Solution casting and electron beam (EB) irradiation were applied to the matrix formulation. The properties of the native matrix and matrices degraded in a PBS buffer (pH 7.4) were monitored by NMR, DSC, GPC, and SEM. Water uptake (WU) and weight loss (WL) were also analyzed. LTP was released over 113 days in a tri-phasic and sigmoidal pattern without a burst effect and with a relatively long second release phase, in which changes were observed in the glass transition temperature, molecular weight (Mn), WU, and WL. EB irradiation decreased the initial Mn, increased WU, and accelerated LTP release with a shortened lag phase. This provides the opportunity to partially eliminate the use of drops at the start of treatment. SEM observations indicated that surface erosion is the prevalent degradation mechanism. The proposed model is an interesting solution during a preliminary study to develop final medicinal products that provide high adherence. Full article
(This article belongs to the Special Issue Advances in Biomaterials and Drug Technology)
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15 pages, 16193 KiB  
Article
The Role of the Mechanical, Structural, and Thermal Properties of Poly(l-lactide-co-glycolide-co-trimethylene carbonate) in the Development of Rods with Aripiprazole
by Artur Turek, Jakub Rech, Aleksandra Borecka, Justyna Wilińska, Magdalena Kobielarz, Henryk Janeczek and Janusz Kasperczyk
Polymers 2021, 13(20), 3556; https://doi.org/10.3390/polym13203556 - 15 Oct 2021
Cited by 3 | Viewed by 2626
Abstract
In this work, we aimed to determine the role of the mechanical, structural, and thermal properties of poly(l-lactide-co-glycolide-co-trimethylene carbonate) (P(l-LA:GA:TMC)) with shape memory in the formulation of implantable and biodegradable rods with aripiprazole (ARP). Hot [...] Read more.
In this work, we aimed to determine the role of the mechanical, structural, and thermal properties of poly(l-lactide-co-glycolide-co-trimethylene carbonate) (P(l-LA:GA:TMC)) with shape memory in the formulation of implantable and biodegradable rods with aripiprazole (ARP). Hot melt extrusion (HME) and electron beam (EB) irradiation were applied in the formulation process of blank rods and rods with ARP. Rod degradation was carried out in a PBS solution. HPLC; NMR; DSC; compression and tensile tests; molecular weight (Mn); water uptake (WU); and weight loss (WL) analyses; and SEM were used in this study. HME and EB irradiation did not influence the structure of ARP. The mechanical tests indicated that the rods may be safely implanted using a pre-filled syringe. During degradation, no unfavorable changes in terpolymer content were observed. A decrease in the glass transition temperature and the Mn, and an increase in the WU and the WL were revealed. The loading of ARP and EB irradiation induced earlier pore formation and more intense WU and WL changes. ARP was released in a tri-phasic model with the lag phase; therefore, the proposed formulation may be administered as a delayed-release system. EB irradiation was found to accelerate ARP release. Full article
(This article belongs to the Special Issue Physicochemical Properties of Biodegradable Polymers)
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15 pages, 4035 KiB  
Article
Effect of Polymer Permeability and Solvent Removal Rate on In Situ Forming Implants: Drug Burst Release and Microstructure
by Xiaowei Zhang, Liqun Yang, Chong Zhang, Danhua Liu, Shu Meng, Wei Zhang and Shengnan Meng
Pharmaceutics 2019, 11(10), 520; https://doi.org/10.3390/pharmaceutics11100520 - 10 Oct 2019
Cited by 36 | Viewed by 5070
Abstract
To explore the mechanism of drug release and depot formation of in situ forming implants (ISFIs), osthole-loaded ISFIs were prepared by dissolving polylactide, poly(lactide-co-glycolide), polycaprolactone, or poly(trimethylene carbonate) in different organic solvents, including N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), and triacetin [...] Read more.
To explore the mechanism of drug release and depot formation of in situ forming implants (ISFIs), osthole-loaded ISFIs were prepared by dissolving polylactide, poly(lactide-co-glycolide), polycaprolactone, or poly(trimethylene carbonate) in different organic solvents, including N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), and triacetin (TA). Drug release, polymer degradation, solvent removal rate and depot microstructure were examined. The burst release effect could be reduced by using solvents exhibit slow forming phase inversion and less permeable polymers. Both the drug burst release and polymer depot microstructure were closely related to the removal rate of organic solvent. Polymers with higher permeability often displayed faster drug and solvent diffusion rates. Due to high polymer-solvent affinity, some of the organic solvent remained in the depot even after the implant was completely formed. The residual of organic solvent could be predicted by solubility parameters. The ISFI showed a lower initial release in vivo than that in vitro. In summary, the effects of different polymers and solvents on drug release and depot formation in ISFI systems were extensively investigated and discussed in this article. The two main factors, polymer permeability and solvent removal rate, were involved in different stages of drug release and depot formation in ISFI systems. Full article
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15 pages, 2192 KiB  
Article
Research on a Nonwoven Fabric Made from Multi-Block Biodegradable Copolymer Based on l-Lactide, Glycolide, and Trimethylene Carbonate with Shape Memory
by Joanna Walczak, Michał Chrzanowski and Izabella Krucińska
Molecules 2017, 22(8), 1325; https://doi.org/10.3390/molecules22081325 - 10 Aug 2017
Cited by 8 | Viewed by 5715
Abstract
The presented paper concerns scientific research on processing a poly(lactide-co-glycolide-co-trimethylene carbonate) copolymer (PLLAGLTMC) with thermally induced shape memory and a transition temperature around human body temperature. The material in the literature called terpolymer was used to produce smart, nonwoven [...] Read more.
The presented paper concerns scientific research on processing a poly(lactide-co-glycolide-co-trimethylene carbonate) copolymer (PLLAGLTMC) with thermally induced shape memory and a transition temperature around human body temperature. The material in the literature called terpolymer was used to produce smart, nonwoven fabric with the melt blowing technique. Bioresorbable and biocompatible terpolymers with shape memory have been investigated for its medical applications, such as cardiovascular stents. There are several research studies on shape memory in polymers, but this phenomenon has not been widely studied in textile products made from shape memory polymers (SMPs). The current research aims to explore the characteristics of the PLLAGLTMC nonwoven fabric in detail and the mechanism of its shape memory behavior. In this study, the nonwoven fabric was subjected to thermo-mechanical, morphological, and shape memory analysis. The thermo-mechanical and structural properties were investigated by means of differential scanning calorimetry, dynamic mechanical analysis, scanning electron microscopic examination, and mercury porosimetry measurements. Eventually, the gathered results confirmed that the nonwoven fabric possessed characteristics that classified it as a smart material with potential applications in medicine. Full article
(This article belongs to the Special Issue Biomedical Applications of Polylactide (PLA) and its Copolymers)
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17 pages, 8616 KiB  
Article
Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior
by Piotr Rychter, Natalia Śmigiel-Gac, Elżbieta Pamuła, Anna Smola-Dmochowska, Henryk Janeczek, Wojciech Prochwicz and Piotr Dobrzyński
Materials 2016, 9(1), 64; https://doi.org/10.3390/ma9010064 - 20 Jan 2016
Cited by 16 | Viewed by 7899
Abstract
The aim of the study was the evaluation of gamma irradiation and electron beams for sterilization of porous scaffolds with shape memory behavior obtained from biodegradable terpolymers: poly(l-lactide-co-glycolide-co-trimethylene carbonate) and poly(l-lactide-co-glycolide-co-ɛ-caprolactone). [...] Read more.
The aim of the study was the evaluation of gamma irradiation and electron beams for sterilization of porous scaffolds with shape memory behavior obtained from biodegradable terpolymers: poly(l-lactide-co-glycolide-co-trimethylene carbonate) and poly(l-lactide-co-glycolide-co-ɛ-caprolactone). The impact of mentioned sterilization techniques on the structure of the scaffolds before and after the sterilization process using irradiation doses ranged from 10 to 25 kGy has been investigated. Treatment of the samples with gamma irradiation at 15 kGy dose resulted in considerable drop in glass transition temperature (Tg) and number average molecular weight (Mn). For comparison, after irradiation of the samples using an electron beam with the same dose, no significant changes in structure or properties of examined scaffolds have been noticed. Higher doses of irradiation via electron beam caused essential changes of the scaffolds’ pores resulting in partial melting of their surface. Nevertheless, obtained results have revealed that sterilization with electron beam, when compared to gamma irradiation, is a better method because it does not affect significantly the physicochemical properties of the scaffolds. Both used methods of sterilization did not influence the shape memory behavior of the examined materials. Full article
(This article belongs to the Special Issue Biodegradable and Bio-Based Polymers)
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