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Keywords = perianal gland tumors

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9 pages, 616 KiB  
Article
Pharmacological Treatment of Perianal Gland Tumors in Male Dogs
by Adam Brodzki, Wojciech Łopuszyński, Piotr Brodzki, Katarzyna Głodkowska, Bartosz Knap and Paulina Gawin
Animals 2023, 13(3), 463; https://doi.org/10.3390/ani13030463 - 28 Jan 2023
Cited by 4 | Viewed by 6502
Abstract
The presence of androgen (AR) and estrogen (ER) receptors has been demonstrated both in normal perianal (hepatoid) glands and in perianal tumors. The aim of this study was to demonstrate the relationship between the expression of AR and ER in perianal gland tumors [...] Read more.
The presence of androgen (AR) and estrogen (ER) receptors has been demonstrated both in normal perianal (hepatoid) glands and in perianal tumors. The aim of this study was to demonstrate the relationship between the expression of AR and ER in perianal gland tumors and the effectiveness of antihormonal treatment. The study was performed on 41 male dogs with neoplastic lesions of the anal region. Histopathological evaluation of the lesions revealed 24 adenomas, 12 epitheliomas, and five carcinomas. Treatment was administered orally with tamoxifen at a dose of 1 mg/kg BW and cyproterone acetate at a dose of 5 mg/kg. Tumor diameters were measured regularly with calipers and recorded in millimeters starting with the measurement before treatment, and then after 1, 2, 3, 6, 12, 18, and 24 months of therapy. The results show that hepatoid adenomas that are characterized by high expression of AR and ER receptors respond positively to antihormonal therapy, resulting in complete tumor regression. For locally malignant hepatoid epitheliomas and carcinomas with low expression of AR and ER receptors, antihormonal therapy makes it possible to reduce the size of the tumor, but does not make it possible to cure it completely. Full article
(This article belongs to the Section Veterinary Clinical Studies)
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11 pages, 1297 KiB  
Article
Androgen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogs
by Adam Brodzki, Wojciech Łopuszyński, Yolanda Millan, Marcin R. Tatara, Piotr Brodzki, Katarzyna Kulpa and Natalia Minakow
Animals 2021, 11(3), 875; https://doi.org/10.3390/ani11030875 - 19 Mar 2021
Cited by 4 | Viewed by 4103
Abstract
Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER) receptors have been demonstrated [...] Read more.
Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER) receptors have been demonstrated both in normal perianal glands as well as in perianal tumors. The aim of the study was an immunohistochemical assessment of the expression of estrogen and androgen receptors in perianal gland tumors in dogs as an applicatory marker for antihormonal treatment. Biopsy samples of perianal masses were collected from 41 male dogs. A histopathological examination revealed 24 adenomas, 12 epitheliomas and five carcinomas. The immunohistochemical staining showed a mainly nuclear expression of AR and ER in the neoplastic cells. Both the androgen and estrogen receptors were expressed in adenoma, epithelioma and carcinoma cases; however, the highest expression of the receptors was stated in the adenoma and epithelioma. In the case of the carcinoma, the expression of sex hormone receptors was very weak. The differences of the number of cells expressing AR and ER as well as the observed differentiated intensity of staining in the studies demonstrated that the determination of the expression of the sex hormone receptors may be useful to elaborate a diagnostic and therapeutic algorithm. Full article
(This article belongs to the Special Issue Spontaneous Neoplasms in Animals)
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