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Keywords = mesuasinone

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10 pages, 300 KB  
Article
Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines
by Soek Sin Teh, Gwendoline Cheng Lian Ee, Siau Hui Mah, Yang Mooi Lim and Zuraini Ahmad
Molecules 2013, 18(2), 1985-1994; https://doi.org/10.3390/molecules18021985 - 4 Feb 2013
Cited by 34 | Viewed by 6391
Abstract
The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4 [...] Read more.
The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities. Full article
(This article belongs to the Section Natural Products Chemistry)
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7 pages, 492 KB  
Article
A Novel Cyclodione Coumarin from the Stem Bark of Mesua beccariana
by Gwendoline Cheng Lian Ee, Soek Sin Teh, Siau Hui Mah, Mawardi Rahmani, Yun Hin Taufiq-Yap and Khalijah Awang
Molecules 2011, 16(9), 7249-7255; https://doi.org/10.3390/molecules16097249 - 25 Aug 2011
Cited by 8 | Viewed by 5987
Abstract
Our ongoing investigations on the stem bark of Mesua beccariana afforded a novel cyclodione coumarin, beccamarin, together with two known xanthones, mesuarianone, mesuasinone, two anthraquinones, 4-methoxy-1,3,5-trihydroxy-anthraquinone and 2,5-dihydroxy-1,3,4-trimethoxyanthraquinone and one coumarin, mammea A/AB. The structures were elucidated by 1D and 2D NMR [...] Read more.
Our ongoing investigations on the stem bark of Mesua beccariana afforded a novel cyclodione coumarin, beccamarin, together with two known xanthones, mesuarianone, mesuasinone, two anthraquinones, 4-methoxy-1,3,5-trihydroxy-anthraquinone and 2,5-dihydroxy-1,3,4-trimethoxyanthraquinone and one coumarin, mammea A/AB. The structures were elucidated by 1D and 2D NMR and MS techniques. Full article
(This article belongs to the Special Issue Coumarins and Xanthones)
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10 pages, 259 KB  
Article
Two New Pyranoxanthones from Mesua beccariana (Guttiferae)
by Soek Sin Teh, Gwendoline Cheng Lian Ee, Mawardi Rahmani, Wei Chung Sim, Siau Hui Mah and Siow Hwa Teo
Molecules 2010, 15(10), 6733-6742; https://doi.org/10.3390/molecules15106733 - 28 Sep 2010
Cited by 10 | Viewed by 8316
Abstract
Our recent study on the stem bark extracts of Mesua beccariana has led to the isolation of two new pyranoxanthones, mesuarianone (1) and mesuasinone (2), two anthraquinones, 4-methoxy-1,3,5-trihydroxyanthraquinone (3) and 2,5-dihydroxy-1,3,4-trimethoxyanthraquinone (4), one coumarin, mammea [...] Read more.
Our recent study on the stem bark extracts of Mesua beccariana has led to the isolation of two new pyranoxanthones, mesuarianone (1) and mesuasinone (2), two anthraquinones, 4-methoxy-1,3,5-trihydroxyanthraquinone (3) and 2,5-dihydroxy-1,3,4-trimethoxyanthraquinone (4), one coumarin, mammea A/AB (5) and three common triterpenes, stigmasterol (6), friedelin (7) and betulinic acid (8). Structural elucidations of these compounds were achieved using 1D and 2D NMR and MS techniques. This is the first report on the phytochemistry of Mesua beccariana. Full article
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