Search Results (6)

From a Platonistic perspective, ideas are eternal and unchanging, constituting the foundation of reality. An idea itself does not change; it is a principle, immutable in essence. This approach inherently establishes a hierarchy, valuing the world of ideas—understood as objective truth—over the sensory world—seen as deceptive and unstable. Against this backdrop, this paper examines the nature of musical ideas as they emerge from Marcel Proust’s work, exploring their potentially antiplatonistic implications and the philosophical insights they inspired in influential 20th-century thinkers. Full article

This study explores the intersection of folklore and literature, specifically examining how a methodology developed for interpreting wondertales can be applied to a complex literary corpus, such as Marcel Proust’s À la recherche du temps perdu (In Search of Lost Time). The discussion proposes a case study for the use of allomotifs, or interchangeable motifs, to understand symbolic patterns in Proust’s literary work. The paper lays bare a widespread metaphorical field in wondertales, then follows its complications in the Proustian corpus. It suggests that Proust’s œuvre, much like folklore, operates within a symbolic universe where binary oppositions, such as good and evil or male and female, are fluid and dynamic. The discussion shows that Proust’s literary imagination aligns surprisingly well with the workings of folklore. This hybrid space of the imagination challenges conventional distinctions between folklore and literature, and brings to mind Lévi-Strauss’ erstwhile ruminations on the pensée sauvage. Full article

Objectives: In this communication, we wish to remember the important historical role played by Marcel Proust’s father, the now mostly forgotten Achille-Adrien Proust (1834–1903). Study Design and Methods: His career, scientific interests and, above all, his brilliant intuitions and suggestions in the fight against cholera in the 19th century are recalled. Results and Conclusions: His role in the promotion of a globally effective vision of public hygiene and health is stressed as a bright example for modern physicians fighting contemporary epidemics. Full article

Esophageal cancer, despite its tendency to increase among younger patients, remains a disease of the elderly, with the peak incidence between 70–79 years. In spite of that, elderly patients are still excluded from major clinical trials and they are frequently offered suboptimal treatment even for curable stages of the disease. In this review, a clear survival benefit is demonstrated for elderly patients treated with neoadjuvant treatment, surgery, and even definitive chemoradiation compared to palliative or no treatment. Surgery in elderly patients is often associated with higher morbidity and mortality compared to younger patients and may put older frail patients at increased risk of autonomy loss. Definitive chemoradiation is the predominant modality offered to elderly patients, with very promising results especially for squamous cell cancer, although higher rates of acute toxicity might be encountered. Based on the all the above, and although the best available evidence comes from retrospective studies, it is not justified to refrain from curative treatment for elderly patients based on their age alone. Thorough assessment and an adapted treatment plan as well as inclusion of elderly patients in ongoing clinical trials will allow better understanding and management of esophageal cancer in this heterogeneous and often frail population. Full article

Background: Predictive biomarkers of response to chemotherapy plus antiangiogenic for metastatic colorectal cancer (mCRC) are lacking. The objective of this study was to test the prognostic role of splenomegaly on baseline CT scan. Methods: This study is a sub-study of PRODIGE-9 study, which included 488 mCRC patients treated by 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) and bevacizumab in first line. The association between splenic volume, and PFS and OS was evaluated by univariate and multivariable Cox analyses. The relation between circulating monocytic Myeloid derived suppressor cells (mMDSC) and splenomegaly was also determined. Results: Baseline splenic volume > 180 mL was associated with poor PFS (median PFS = 9.2 versus 11.1 months; log-rank p = 0.0125), but was not statistically associated with OS (median OS = 22.6 versus 28.5 months; log-rank p = 0.1643). The increase in splenic volume at 3 months had no impact on PFS (HR 0.928; log-rank p = 0.56) or on OS (HR 0.843; log-rank p = 0.21). Baseline splenic volume was positively correlated with the level of baseline circulating mMDSC (r = 0.48, p-value = 0.031). Conclusion: Baseline splenomegaly is a prognostic biomarker in patients with mCRC treated with FOLFIRI and bevacizumab, and a surrogate marker of MDSC accumulation. Full article

This essay takes up the encounter between philosophy and literature through a reconsideration of Walter Benjamin’s remarks from “On Some Motifs in Baudelaire” about Henri Bergson’s Matière et mémoire as an attempt “[t]owering above” other ventures into Lebensphilosophie to “lay hold of the ‘true’ experience, as opposed to the kind that manifests itself in the standardized, denatured life of the civilized masses”. Despite his initial affirmation of Bergson’s understanding of experience as connected with tradition, Benjamin criticizes the philosopher’s account for sidestepping “the alienating, blinding experience of the age of large-scale industrialism” in reaction to which, as Benjamin insists, Bergson’s philosophy of memory developed. Yet even as Bergson shuts out the historical import of modernization, according to Benjamin, he also spotlights a “complementary” visual experience “in the form of its spontaneous afterimage”. Benjamin subsequently defines Bergson’s philosophy as “an attempt to specify this afterimage and fix it as a permanent record”, an endeavor that inadvertently “furnishes a clue to the experience which presented itself undistorted to Baudelaire’s eyes, in the figure of his reader”. If the literary critic might be viewed here as weighing in on a long-running antagonism between philosophy and literature, then his assessment is resolute: by praising the self-conscious historicity of Baudelaire’s lyric, Benjamin declares that poetry succeeds where Lebensphilosophie fails. Notably, Baudelaire is not the only figure to upstage “ahistorical” Bergson, since Marcel Proust and Sigmund Freud facilitate this victory. To contextualize the second section of “Motifs”, where Benjamin discusses the novelist’s “immanent critique of Bergson” this essay offers a reading of “On the Image of Proust” as a propadeutic to Benjamin’s privileging of “Baudelaire” over “Bergson” in the first section of “Motifs” to broach the destinies of diminished perception before he turns to Freud in the third section. Drawing upon Freud’s thermodynamic model of a selective and protective perceptual-conscious system from Beyond the Pleasure Principle, Benjamin explains how perception calcifies in adapting to industrialism. Notably, however, his “energetics” does not remain bound by closed-system economic premises insofar as he conceives Baudelaire’s correspondances as an antidote to reification and modernization fatigue. The resulting configuration emerges against the backdrop of a lament about the decline of tradition-infused, long-term experience [Erfahrung] that accompanies the rise of isolated experience [Erlebnis]. In tracking Benjamin’s seemingly melancholic emplotment of the literary image between “Proust” and “Baudelaire”, the essay ultimately focuses on how he amplifies its sociohistorical potential to attest to the dehiscence of tradition as a community-sustaining force. Full article