Search Results (8)

National Key Ecological Functional Areas (NKEFAs) play an important role in forestry restoration, water source conservation, soil and water conservation, windbreak and sand fixation, and biodiversity maintenance. They are the strategic core of ecosystem protection and restoration projects, not only directly related to ecological environment construction, but also profoundly affecting the sustainable development capacity of regional economy. This article selects 1256 ecologically and economically representative counties in China with complete data as research objects. Based on the data of the selected counties from 2007 to 2021, the entropy weight TOPSIS method is used to construct an economic resilience index, and a multi-period difference-in-differences (DID) model is adopted to explore the specific impact of the establishment of national key ecological functional areas on China’s economic resilience. Research has shown that national key ecological functional areas can enhance the resilience of county-level economies by promoting economic agglomeration and factor agglomeration, increasing fiscal expenditure and investment levels, and promoting sustainable development of county-level economies. The establishment of national key ecological functional areas in economically underdeveloped areas has had a positive effect on economic resilience, and the establishment of water source conservation, soil and water conservation, and biodiversity maintenance ecological functional areas has a significant impact on economic resilience. Therefore, national key ecological functional areas have generally promoted the improvement of China’s economic resilience, but in the process of policy implementation, the establishment of national key ecological functional areas should be promoted according to local conditions. This article not only provides empirical evidence for the effectiveness of China’s national key ecological function areas policies, but also provides methodological inspiration for formulating more precise and scientific ecological protection policies, which has reference significance for the implementation of similar policies in other regions around the world. Full article

The financial implications of long-term restoration projects for cultural heritage, as compared to regular maintenance efforts, often underscore a flawed decision-making process. This can result from years of neglect versus consistent, organized maintenance. Striking a balance between these strategies is paramount for preserving cultural legacies. This research aims to evaluate the trade-offs between the initial expenditures of restoration initiatives and the consistent costs of maintenance activities. We leverage Building Information Modelling (BIM) and its specialized application for heritage preservation, known as Heritage Building Information Modelling (HBIM). This offers a digital depiction of the heritage building’s conservation state and associated intervention costs. Specifically, this study taps into the fifth dimension of BIM, cost estimation, to draw a comparative analysis between the financial ramifications of regular maintenance and long-term restoration projects. This assessment is exemplified through a case study on the “Aidkeen Al-Bendqdari Dome” located in historic Cairo, Egypt—a component of the Prince Taz Palace. The analysis integrates cost data to generate insights. The ultimate goal is to devise a comparative framework that can guide authorities in budgetary decisions and resource distribution. Full article

Energy performance contracting (EPC) is the best solution for an educational building to implement energy conservation measures (ECMs) because of its high capital expenditure and operational expenditure needed for retrofit and maintenance. It is also considered a win–win mechanism for organising building energy efficiency retrofit projects. It aims to assist educational buildings in acquiring new high-efficiency equipment and maximising energy use reduction, as guaranteed by energy service company (ESCO). This study developed an EPC model using regression analysis, in which the inputs are based on the data collected during the preliminary energy audit in University A. As a result, with a quantum sharing ratio of 0.95/0.5 for ESCO/University A, the forecasted energy savings from the proposed ECMs, chiller optimisation and replacement, lighting retrofit, and energy management system are estimated to save 25.6% energy use, which reduces 5,672,057 kilowatt-hour (kWh) in electricity consumption; saves RM 2,762,291.76/year; carbon dioxide (CO₂) mitigation equal to 3,771,061.22 kgCO₂/year; return of investment of 4.2 years with a 5% interest rate; and building energy intensity of 93.55 kWh/m²/year. A sensitivity analysis of various quantum sharing ratios found that the saving value of ESCO is inversely proportional to that of University A as the client when the quantum sharing ratio for the former is increasing. Full article

Horticultural crops comprise various economic species extending from fruits, nuts, vegetables, spices and condiments, ornamentals, aromatic, and medicinal plants. Ornamental and fruit plants are produced mainly for their nutritional and aesthetic values, respectively. Unfortunately, many tropical and subtropical species are in danger of extinction because of climate change and (a)biotic stresses. It is imperative to preserve the germplasms of these species for the present and future genetic improvement programs. Cryopreservation, i.e., maintenance of tissues at the ultralow temperature of liquid nitrogen, is a promising long-term preservation technique, alternative to seed or in vitro banks, which can be applied for both vegetatively and generatively (through seeds) propagated crops, including those with recalcitrant seeds. It is a technology of choice not only for the preservation of plant biodiversity but also for virus elimination in the proficient administration of large-scale micropropagation. The main advantages of cryopreservation are the lowering of in vitro culture expenditures, needed space, contamination risk, and operator errors. However, tropical species are temperature delicate and one of the foremost challenging issues is preconditioning treatments that stimulate physiological reactions to sufficiently enhance tolerance to dehydration and cryogenic procedures. In recent years, several cryopreservation methods based on encapsulation-vitrification, droplet-vitrification, the use of aluminum cryo-plates, and cryo-mesh have been established. Combined cryo-techniques, gene/DNA conservation, as well as studies on perceiving bio-molecular events and exploring the multistage process from the beginning to end of cryopreservation are receiving more emphasis. The development of cryobiomics delivers a conceptual framework to assess the significance of cell signaling mechanisms on cellular functions, the influence of cryoinjury factors on sample viability, and the implications for genetic stability following cryo-storage. The aim of this mini-review article is to provide a succinct synthesis of the developed cryogenic procedures and their use for the storage and exchange of genetic resources of tropical and subtropical horticultural crops, particularly fruit crops and ornamental plants under the threat of extinction. Full article

Despite efforts to promote universal access to electrification, the Brazilian Amazon basin has around 82,000 families without electricity. The basin is huge, with few roads, many rivers, and conservative areas, which is an enormous challenge in terms of logistics and electrification costs. This paper describes a case study at the Nova Esperança community site in the Cuieiras River, Brazil. The community received stand-alone solar photovoltaic systems in 2018 and 2019. The process started with a survey and finished with an interview with each dweller that received a 975 W and 2-day autonomy photovoltaic system. A monitoring system was developed and deployed, and weather monitoring was performed to evaluate the impact of high temperatures on the equipment. The community does not have cell phone coverage and it is far from the main cities. We claim that the model created and adopted in the case study has interesting outcomes, even considering a small budget. Some houses, after 1 year of deployment, had their electrical demand rise by 300%, and 50% improved their income. We estimate the number of greenhouse gases annually avoided after electrification, replacing the consumed fossil fuel. The project also estimates the expenditure on energy sources that residents used due to the lack of electricity, which they stopped doing after electrification. The avoided expense can cover maintenance costs over the years. The goals of the SDG that were covered by the project are good health and well-being, accessible and clean energy, sustainable cities and communities, combating climate change, and partnerships for the goals. Full article

This paper applies the Road Network Evaluation Tools (RONET) model to assess the economic impacts of urban pavement maintenance and rehabilitation in the city of Munster, Germany. The city’s road network includes main roads, main access roads, residential roads, and paved areas for pedestrians, cyclists, and parking spaces. The specific traffic loads applied to Munster’s network demand several different pavement materials, structures, and intervention procedures. This study aims to support stakeholders’ decision-making by assessing current expenditures, network conditions, and country-specific data to determine the appropriate financial allocation for recurrent maintenance, periodic maintenance, rehabilitation, and new pavement construction. Six scenarios comprising distinct pavement structures and maintenance strategies are modeled in RONET to perform the analysis. The outcomes include the future deterioration of pavements under different maintenance scenarios, the current and projected asset value of the network, and the total costs (road agency costs + user costs) of the network to society, considering each scenario being applied over a 20-year evaluation period. The RONET model also provides the annual average cost of each maintenance procedure and the additional costs to society while using a budget scenario other than ‘Optimal.’ The results indicate that Munster’s current investment program is in line with the ‘Optimal’ budget scenario proposed by RONET. In addition, the model suggests that performing recurrent and periodic interventions is more cost-effective than neglecting the conservation of pavements for an extended period and endorsing more extensive interventions in the future, such as rehabilitation or reconstruction. Full article

The aim of this study is to analyse whether the economic resources invested in roads—both investment in construction and expenditure on maintenance and conservation—have any influence on road fatality rates. Since this is a complex problem, and because there are many factors that can influence the fatality rate, other variables related to specific transport, socioeconomic and meteorological factors are also considered. The study was carried out using a panel data model, modelling road mortality as a function of 12 variables. The scope of the study is international, focusing on the interurban road network. Data were collected from 23 European countries for the period 1998–2016. The main results obtained are that both expenditure on road maintenance and conservation and the proportion of motorways in the total road network contribute to reducing road mortality. Contrariwise, greater investment in construction leads to an increase in the fatality rate. Full article

As a tumor suppressor and the most frequently mutated gene in cancer, p53 is among the best-described molecules in medical research. As cancer is in most cases an age-related disease, it seems paradoxical that p53 is so strongly conserved from early multicellular organisms to humans. A function not directly related to tumor suppression, such as the regulation of metabolism in nontransformed cells, could explain this selective pressure. While this role of p53 in cellular metabolism is gradually emerging, it is imperative to dissect the tissue- and cell-specific actions of p53 and its downstream signaling pathways. In this review, we focus on studies reporting p53’s impact on adipocyte development, function, and maintenance, as well as the causes and consequences of altered p53 levels in white and brown adipose tissue (AT) with respect to systemic energy homeostasis. While whole body p53 knockout mice gain less weight and fat mass under a high-fat diet owing to increased energy expenditure, modifying p53 expression specifically in adipocytes yields more refined insights: (1) p53 is a negative regulator of in vitro adipogenesis; (2) p53 levels in white AT are increased in diet-induced and genetic obesity mouse models and in obese humans; (3) functionally, elevated p53 in white AT increases senescence and chronic inflammation, aggravating systemic insulin resistance; (4) p53 is not required for normal development of brown AT; and (5) when p53 is activated in brown AT in mice fed a high-fat diet, it increases brown AT temperature and brown AT marker gene expression, thereby contributing to reduced fat mass accumulation. In addition, p53 is increasingly being recognized as crucial player in nutrient sensing pathways. Hence, despite existence of contradictory findings and a varying density of evidence, several functions of p53 in adipocytes and ATs have been emerging, positioning p53 as an essential regulatory hub in ATs. Future studies need to make use of more sophisticated in vivo model systems and should identify an AT-specific set of p53 target genes and downstream pathways upon different (nutrient) challenges to identify novel therapeutic targets to curb metabolic diseases. Full article