Natural products are an important source of pesticide discovery. A series of
N-amino-maleimide derivatives containing hydrazone group were designed and synthesized based on the structure of linderone and methyllinderone which were isolated from
Lindera erythrocarpa Makino. According to the bioassay results, compounds
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Natural products are an important source of pesticide discovery. A series of
N-amino-maleimide derivatives containing hydrazone group were designed and synthesized based on the structure of linderone and methyllinderone which were isolated from
Lindera erythrocarpa Makino. According to the bioassay results, compounds
2 and
3 showed 60% inhibition against mosquito (
Culex pipiens pallens) at 0.25 µg·mL
−1. Furthermore, the results of antifungal tests indicated that most compounds exhibited much better antifungal activities against fourteen phytopathogenic fungi than linderone and methyllinderone and some compounds exhibited better antifungal activities than commercial fungicides (carbendazim and chlorothalonil) at 50 µg·mL
−1. In particular, compound
12 exhibited broad-spectrum fungicidal activity (>50% inhibitory activities against 11 phytopathogenic fungi) and compounds
12 and
14 displayed 60.6% and 47.9% inhibitory activity against
Rhizoctonia cerealis at 12.5 µg·mL
−1 respectively. Furthermore, compound
17 was synthesized, which lacks N-substituent at maleimide and its poor antifungal activity against
Sclerotinia sclerotiorum and
Rhizoctonia cerealis at 50 µg·mL
−1 showed that the backbone structure of
N-amino-maleimide derivatives containing hydrazone group was important to the antifungal activity.
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