Search Results (5)

Swept-source optical coherence tomography (SS-OCT) is a widely used imaging technique, particularly in medical diagnostics, due to its ability to provide high-resolution cross-sectional images. However, one of the main challenges in SS-OCT systems is the nonlinearity in wavelength sweeping, which leads to degraded depth resolution after Fourier transform. Correcting for this nonlinearity typically requires complex re-sampling and chirp compensation methods. In this paper, we introduce the first ultrafast time-stretch optical coherence tomography (TS-OCT) system that utilizes reservoir computing (RC) to perform direct temporal signal analysis without relying on Fourier transform techniques. By focusing solely on the temporal characteristics of the interference signal, regardless of frequency chirp, we demonstrate a more efficient solution to address the nonlinear wavelength sweeping issue. By leveraging the dynamic temporal processing capabilities of RC, the proposed system effectively bypasses the challenges faced by Fourier analysis, maintaining high-resolution depth measurement without being affected by chirp-introduced spectral broadening. The system operates by categorizing the interference signals generated by variations in sample position. This classification-based approach simplifies the data processing pipeline. We developed an RC-based model to interpret the temporal patterns in the interferometric signals, achieving high classification accuracy. A proof-of-the-concept experiment demonstrated that this method allows for precise depth resolution, independent of system chirp. With an A-scan rate of 50 MHz, the classification model yielded 100% accuracy with a root mean square error (RMSE) of 0.2416. This approach offers a robust alternative to Fourier-based analysis, particularly in systems prone to nonlinearities during signal acquisition. Full article

This study evaluates the capability of an unconstrained tomographic algorithm to capture 3D water vapor density variability throughout 2017 in Houston, U.S. The algorithm relies solely on Global Navigation Satellite System (GNSS) observations and does not require an initial guess or other specific constraints regarding water vapor density variability within the tomographic domain. The test domain, featuring 9 km horizontal, 500 m vertical, and 30 min temporal resolutions, yielded remarkable results when compared to data retrieved from the ECMWF Reanalysis v5 (ERA5), regional Weather Research and Forecasting Model (WRF) data, and GNSS-Radio Occultation (RO). For the first time, a time series of Precipitable Water Vapor maps derived from the Interferometric Synthetic Aperture Radar (InSAR) technique was used to validate the spatially integrated water vapor computed by GNSS tomography. Tomographic results clearly indicate the passage of Hurricane Harvey, with integrated water vapor peaking at 60 kg/m² and increased humidity at altitudes up to 7.5 km. Our findings suggest that GNSS tomography holds promise as a reliable source of atmospheric water vapor data for various applications. Future enhancements may arise from denser and multi-constellation networks. Full article

The sudden outbreak of the COVID-19 pandemic led to a huge concern globally because of the astounding increase in mortality rates worldwide. The medical imaging computed tomography technique, whole-genome sequencing, and electron microscopy are the methods generally used for the screening and identification of the SARS-CoV-2 virus. The main aim of this review is to emphasize the capabilities of various optical techniques to facilitate not only the timely and effective diagnosis of the virus but also to apply its potential toward therapy in the field of virology. This review paper categorizes the potential optical biosensors into the three main categories, spectroscopic-, nanomaterial-, and interferometry-based approaches, used for detecting various types of viruses, including SARS-CoV-2. Various classifications of spectroscopic techniques such as Raman spectroscopy, near-infrared spectroscopy, and fluorescence spectroscopy are discussed in the first part. The second aspect highlights advances related to nanomaterial-based optical biosensors, while the third part describes various optical interferometric biosensors used for the detection of viruses. The tremendous progress made by lab-on-a-chip technology in conjunction with smartphones for improving the point-of-care and portability features of the optical biosensors is also discussed. Finally, the review discusses the emergence of artificial intelligence and its applications in the field of bio-photonics and medical imaging for the diagnosis of COVID-19. The review concludes by providing insights into the future perspectives of optical techniques in the effective diagnosis of viruses. Full article

We present a multidisciplinary approach for predicting how sperm cells with various morphologies swim in three-dimensions (3D), from milliseconds to much longer time scales at spatial resolutions of less than half a micron. We created the sperm 3D geometry and built a numerical mechanical model using the experimentally acquired dynamic 3D refractive-index profiles of sperm cells swimming in vitro as imaged by high-resolution optical diffraction tomography. By controlling parameters in the model, such as the size and shape of the sperm head and tail, we can then predict how different sperm cells, normal or abnormal, would swim in 3D, in the short or long term. We quantified various 3D structural factor effects on the sperm long-term motility. We found that some abnormal sperm cells swim faster than normal sperm cells, in contrast to the commonly used sperm selection assumption during in vitro fertilization (IVF), according to which sperm cells should mainly be chosen based on their progressive motion. We thus establish a new tool for sperm analysis and male-infertility diagnosis, as well as sperm selection criteria for fertility treatments. Full article

Three-dimensional image formation in microscopy is greatly enhanced by the use of computed imaging techniques. In particular, Interferometric Synthetic Aperture Microscopy (ISAM) allows the removal of out-of-focus blur in broadband, coherent microscopy. Earlier methods, such as optical coherence tomography (OCT), utilize interferometric ranging, but do not apply computed imaging methods and therefore must scan the focal depth to acquire extended volumetric images. ISAM removes the need to scan the focus by allowing volumetric image reconstruction from data collected at a single focal depth. ISAM signal processing techniques are similar to the Fourier migration methods of seismology and the Fourier reconstruction methods of Synthetic Aperture Radar (SAR). In this article ISAM is described and the close ties between ISAM and SAR are explored. ISAM and a simple strip-map SAR system are placed in a common mathematical framework and compared to OCT and radar respectively. This article is intended to serve as a review of ISAM, and will be especially useful to readers with a background in SAR. Full article