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Keywords = inflammatory pseudotumor-like follicular dendritic cell sarcoma

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18 pages, 12444 KiB  
Review
A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors
by Oswald Zhao Jian Lee, Noorjehan Omar, Joshua K. Tay and Victor Kwan Min Lee
Cancers 2023, 15(23), 5563; https://doi.org/10.3390/cancers15235563 - 24 Nov 2023
Cited by 8 | Viewed by 3565
Abstract
The Epstein–Barr virus (EBV) is associated with various tumor types, including nasopharyngeal carcinoma and lymphoproliferative disorders. While much is known about EBV-related epithelial and lymphoid tumors, there is a paucity of knowledge concerning EBV-associated mesenchymal tumors. This review aims to provide a comprehensive [...] Read more.
The Epstein–Barr virus (EBV) is associated with various tumor types, including nasopharyngeal carcinoma and lymphoproliferative disorders. While much is known about EBV-related epithelial and lymphoid tumors, there is a paucity of knowledge concerning EBV-associated mesenchymal tumors. This review aims to provide a comprehensive overview of EBV-associated mesenchymal tumors, encompassing their clinical features, pathological characteristics, pathophysiology, prognostic factors, and current treatment approaches. Through an extensive literature search using the PubMed database, we were able to identify three distinct EBV-associated mesenchymal tumors: EBV-associated smooth muscle tumors, inflammatory pseudotumor-like follicular dendritic cell sarcomas, and EBV-associated osteosarcomas. Although this review extensively explored the different aspects of these mesenchymal tumors, our comprehension of the underlying pathophysiology in this context is still incomplete. Therefore, we hope that this review paper will not only serve as a valuable repository of information but also serve as a catalyst for prospective in vitro and in vivo research studies to bridge the existing knowledge gap surrounding pathophysiology, ultimately making an important contribution to shaping future therapeutic approaches. Full article
(This article belongs to the Special Issue Epstein–Barr Virus (EBV) Associated Cancers)
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6 pages, 4885 KiB  
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Aggressive Variant of Hepatic Epstein–Barr Virus-Associated Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma with PD-L1 and SSTR2a Expression
by Madhur Pardasani, Muthukumarassamy Rajakannu, Mukul Vij, Rajesh Rajalingam and Mohamed Rela
Diagnostics 2023, 13(18), 2916; https://doi.org/10.3390/diagnostics13182916 - 12 Sep 2023
Cited by 1 | Viewed by 1716
Abstract
An aggressive Epstein–Barr virus (EBV)-associated inflammatory pseudotumor-like follicular dendritic cell (IPT-like FDC) sarcoma is reported in an adult female. The patient developed multifocal recurrence and passed away 13 months after the initial surgical resection. A bright field microscopic examination of the tumor demonstrated [...] Read more.
An aggressive Epstein–Barr virus (EBV)-associated inflammatory pseudotumor-like follicular dendritic cell (IPT-like FDC) sarcoma is reported in an adult female. The patient developed multifocal recurrence and passed away 13 months after the initial surgical resection. A bright field microscopic examination of the tumor demonstrated a classical growth pattern and the diffuse expression of Programmed death ligand 1 (PD-L1) and somatostatin receptor 2a (SSTR2a). Full article
(This article belongs to the Special Issue Pathology of Hepatobiliary Diseases)
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