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Keywords = heme oxgenase-1 (HO-1)

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21 pages, 3126 KiB  
Article
Effect of Heme Oxygenase-1 on Melanoma Development in Mice—Role of Tumor-Infiltrating Immune Cells
by Halina Was, Tomasz Cichon, Ryszard Smolarczyk, Bozena Lackowska, Agnieszka Mazur-Bialy, Magdalena Mazur, Agata Szade, Pawel Dominik, Milena Mazan, Jerzy Kotlinowski, Anna Zebzda, Anna Kusienicka, Claudine Kieda, Jozef Dulak and Alicja Jozkowicz
Antioxidants 2020, 9(12), 1223; https://doi.org/10.3390/antiox9121223 - 3 Dec 2020
Cited by 13 | Viewed by 3673
Abstract
Objective: Heme oxygenase-1 (HO-1) is a cytoprotective, proangiogenic and anti-inflammatory enzyme that is often upregulated in tumors. Overexpression of HO-1 in melanoma cells leads to enhanced tumor growth, augmented angiogenesis and resistance to anticancer treatment. The effect of HO-1 in host cells on [...] Read more.
Objective: Heme oxygenase-1 (HO-1) is a cytoprotective, proangiogenic and anti-inflammatory enzyme that is often upregulated in tumors. Overexpression of HO-1 in melanoma cells leads to enhanced tumor growth, augmented angiogenesis and resistance to anticancer treatment. The effect of HO-1 in host cells on tumor development is, however, hardly known. Methods and results: To clarify the effect of HO-1 expression in host cells on melanoma progression, C57BL/6xFvB mice of different HO-1 genotypes, HO-1+/+, HO-1+/−, and HO-1−/−, were injected with the syngeneic wild-type murine melanoma B16(F10) cell line. Lack of HO-1 in host cells did not significantly influence the host survival. Nevertheless, in comparison to the wild-type counterparts, the HO-1+/− and HO-1−/− males formed bigger tumors, and more numerous lung nodules; in addition, more of them had liver and spleen micrometastases. Females of all genotypes developed at least 10 times smaller tumors than males. Of importance, the growth of primary and secondary tumors was completely blocked in HO-1+/+ females. This was related to the increased infiltration of leukocytes (mainly lymphocytes T) in primary tumors. Conclusions: Although HO-1 overexpression in melanoma cells can enhance tumor progression in mice, its presence in host cells, including immune cells, can reduce growth and metastasis of melanoma. Full article
(This article belongs to the Special Issue Pharmacological and Clinical Significance of Heme Oxygenase-1)
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