Search Results (24)

The National Adaptation Plan of Bangladesh identifies eleven climate-stressed zones, placing nearly 100 million people at high risk of climate-related hazards. Vulnerable groups such as the poor, floating populations, daily laborers, and slum dwellers are particularly affected. However, there is a lack of data on climate-sensitive diseases and related hospital visits in these areas. This study explored the prevalence of such diseases using the Delphi method through focus group discussions with 493 healthcare professionals from 153 hospitals in 156 upazilas across 21 districts and ten zones. Participants were selected by district Civil Surgeons. Key climate-sensitive diseases identified included malnutrition, diarrhea, pneumonia, respiratory infections, typhoid, skin diseases, hypertension, cholera, mental health disorders, hepatitis, heat stroke, and dengue. Seasonal surges in hospital visits were noted, influenced by factors like extreme heat, air pollution, floods, water contamination, poor sanitation, salinity, and disease vectors. Some diseases were zone-specific, while others were widespread. Regions with fewer hospital visits often had higher disease burdens, indicating under-reporting or lack of access. The findings highlight the need for area-specific adaptation strategies and updates to the Health National Adaptation Plan. Strengthening resilience through targeted investment and preventive measures is crucial to reducing health risks from climate change. Full article

This research has developed a heat stroke warning system prototype for athletes utilizing the following sensors: DHT22, GY-906-BAA MLX90614, MAX30102. The device calculates the heat stroke risk and notifies users. The data is recorded, stored, displayed on a free-access website which graphs body temperature, ambient temperature, humidity, heart rate and heat stroke risk, and provides notifications for athletes engaged in outdoor activities. The researchers recorded sensors data (n = 1) for two sessions (12 min/session) in a closed room, at the sixth-minute marker, with an air conditioner activated to observe the changes observed by the sensors. For accuracy, the researchers employed Criterion-Related Validity, comparing sensor against standard equipment measurement. For reliability, we utilized Test-Retest Reliability, comparing sensor data from the first and second measurements. Accuracy and reliability were evaluated using the Pearson Correlation Coefficient, with significance set at p < 0.01. The DHT22 sensor demonstrates very high accuracy (r = 0.923) in ambient temperature and (r = 0.774) humidity measurements. It showed no significant reliability (r = 0.489) in temperature and (r = 0.185) humidity measurements. The GY-906-BAA MLX90614 sensor exhibited very high accuracy (r = 0.923) and reliability (r = 0.866) in body temperature measurements. The MAX30102 sensor lacked significant accuracy (r = 0.179) and reliability (r = 0.171) in heart rate measurements. The development of accuracy and reliability of sensors are important for preventing heat stroke in future applications. Full article

Adaptation measures to urban heat islands are classified into the following three categories: measures to reduce solar radiation incident on the human body, measures to control and cool ground and wall surface temperature, and measures to control and cool the air and human body temperature. Case studies are conducted to evaluate the effects of the implementation of a cool water circulation sunshade and to examine the adverse effects of cool pavements on the human thermal environment, in addition to the effects of mist sprays on the human body. The effect of the sunshade, watering road, and mist spray, which are typical adaptation measures to urban heat islands, on the human thermal environment was estimated using Wet Bulb Globe Temperature (WBGT) as an indicator for heat stroke prevention and Standard New Effective Temperature (SET*) as an indicator for thermal comfort assessment. The effect of solar radiation shielding on improving the human thermal environment was the most significant, with a large decrease in the amount of solar radiation absorbed by the human body, resulting in a large decrease in SET* and WBGT of 2.7 °C and 1.0 °C, respectively, on fine summer days. Full article

Heat stress due to high temperatures can cause heat stroke, pyrexia, heat cramps, heart disease, and respiratory diseases, which seriously affect human health. Vitexin has been shown to alleviate heat stress; however, its mechanism of action remains unclear. Therefore, in this study, we used Caco-2 cells to establish a heat stress model and vitamin C as a positive control to investigate the regulatory effects of vitexin on heat-stress-induced apoptosis and the related mechanisms using Cell Counting Kit-8, flow cytometry, real-time quantitative polymerase chain reaction, and Western blot. The results showed that the mRNA expressions of Hsp27, Hsp70, and Hsp90 induced by heat stress could be effectively inhibited at vitexin concentrations as low as 30 μM. After heat stress prevention and heat stress amelioration in model cells based on this concentration, intracellular reactive oxygen species (ROS) levels and the mRNA level and the protein expression of heat shock proteins (Hsp70 and Hsp90) and apoptotic proteins were reduced. In addition, compared with the heat stress amelioration group, the expression of BCL2 mRNA and its protein (anti-apoptotic protein Bcl-2) increased in the heat stress prevention group, while the expression of BAX, CYCS, CASP3, and PARP1 mRNAs and their proteins (apoptotic proteins Bax, Cytochrome C, cle-Caspase-3, and cle-PARP1) were decreased. In summary, the heat-stress-preventive effect of vitexin was slightly better than its heat-stress-ameliorating effect, and its mechanism may be through the inhibition of intracellular ROS levels and thus the modulation of the expressions of Hsp70 and Hsp90, which in turn protects against heat-stress-induced apoptosis. This study provides a theoretical basis for the prevention and amelioration of heat stress using vitexin. Full article

Hypoxia-induced vascular endothelial dysfunction (VED) is a significant contributor to several severe human diseases, including heart disease, stroke, dementia, and cancer. However, current treatment options for VED are limited due to the lack of understanding of the underlying disease mechanisms and therapeutic leads. We recently discovered a heat-stable microprotein in ginseng, called ginsentide TP1, that has been shown to reduce vascular dysfunction in cardiovascular disease models. In this study, we use a combination of functional assays and quantitative pulsed SILAC proteomics to identify new proteins synthesized in hypoxia and to show that ginsentide TP1 provides protection for human endothelial cells against hypoxia and ER stress. Consistent with the reported findings, we also found that hypoxia activates various pathways related to endothelium activation and monocyte adhesion, which in turn, impairs nitric oxide (NO) synthase activity, reduces the bioavailability of NO, and increases the production of reactive oxygen species that contribute to VED. Additionally, hypoxia triggers endoplasmic reticulum stress and initiates apoptotic signaling pathways associated with cardiovascular pathology. Treatment with ginsentide TP1 reduced surface adhesion molecule expression, prevented activation of the endothelium and leukocyte adhesion, restored protein hemostasis, and reduced ER stress to protect against hypoxia-induced cell death. Ginsentide TP1 also restored NO signaling and bioavailability, reduced oxidative stress, and protected endothelial cells from endothelium dysfunction. In conclusion, this study shows that the molecular pathogenesis of VED induced by hypoxia can be mitigated by treatment with ginsentide TP1, which could be one of the key bioactive compounds responsible for the “cure-all” effect of ginseng. This research may lead to the development of new therapies for cardiovascular disorders. Full article

This study numerically analyses the effects of chamber modifications to investigate the improvement of in-cylinder combustion characteristics of the diesel engine using a computational fluid dynamics (CFD) approach. Five different modified chambers, namely, the double swirl combustion chamber (DSCC), bathtub combustion chamber (BTCC), double toroidal re-entrant combustion chamber (DTRCC), shallow depth combustion chamber (SCC), and stepped bowl combustion chamber (SBCC) were developed and compared with a reference flat combustion chamber (FCC). The effects of chamber modifications on temperature formation, velocity distribution, injection profiles, and in-cylinder turbulent motions (swirl and tumble ratio) were investigated. During the compression stroke, near top dead centre, the SCC showed a peak temperature of 970 K, followed by the FCC (968 K), SBCC (967 K), and DTRCC (748 K to 815 K). The DSCC and the SCC showed a high swirl ratio above 0.6, whereas the DTRCC and the BTCC showed a high tumble ratio of approximately 0.4. This study found that the SCC, BTCC, and DSCC have better combustion rates than the FCC in terms of temperature, heat release rate, and velocity distribution. However, the DTRCC showed poor temperature formation rates and rapid heat release rates (approx. 150 J/°CA), which can lead to rapid combustion and knocking tendencies. In conclusion, the DSCC and the SCC showed better combustion rates than the other chambers. In addition, turbulent motions inside the chambers avoided combustion in crevice regions. This study recommends avoiding chambers with wider bowls in order to prevent uneven combustion across the cylinder. Furthermore, split bowls such as the DSCC, along with adjusted injection rates, can provide better results in terms of combustion. Full article

Cardiovascular drift—a progressive increase in heart rate (HR) and decrease in stroke volume (SV) during prolonged exercise—is exacerbated by heat stress and thermal strain, and often accompanied by a decrease in work capacity (indexed as maximal oxygen uptake [$\stackrel{.}{\mathrm{V}}$O_2max]). To attenuate physiological strain during work in the heat, use of work:rest ratios is recommended by the National Institute for Occupational Safety and Health. The purpose of this study was to test the hypothesis that during moderate work in hot conditions, utilizing the recommended 45:15 min work:rest ratio would result in cardiovascular drift ‘accumulating’ over consecutive work:rest cycles and accompanying decrements in $\stackrel{.}{\mathrm{V}}$O_2max. Eight people (5 women; (mean ± SD) age = 25 ± 5 y; body mass = 74.8 ± 11.6 kg; $\stackrel{.}{\mathrm{V}}$O_2max = 42.9 ± 5.6 mL·kg⁻¹·min⁻¹) performed 120 min of simulated moderate work (201–300 kcal·h⁻¹) in hot conditions (indoor wet-bulb globe temperature = 29.0 ± 0.6 °C). Participants completed two 45:15 min work:rest cycles. Cardiovascular drift was evaluated at 15 and 45 min of each work bout; $\stackrel{.}{\mathrm{V}}$O_2max was measured after 120 min. On a separate day, $\stackrel{.}{\mathrm{V}}$O_2max was measured after 15 min under identical conditions for comparison before and after cardiovascular drift occurred. HR increased 16.7% (18 ± 9 beats·min⁻¹, p = 0.004) and SV decreased 16.9% (−12.3 ± 5.9 mL, p = 0.003) between 15 and 105 min, but $\stackrel{.}{\mathrm{V}}$O_2max was unaffected after 120 min (p = 0.14). Core body temperature increased 0.5 ± 0.2 °C (p = 0.006) over 2 h. Recommended work:rest ratios preserved work capacity but did not prevent the accumulation of cardiovascular and thermal strain. Full article

This study aims to explore the longitudinal relationship between solid fuel use and CMD incidence based on a nationally representative follow-up cohort study. A total of 6038 participants of the China Health and Retirement Longitudinal Study (CHARLS) were enrolled in the study. CMD is a cluster of diseases that include heart disease, stroke, and type 2 diabetes. Cox proportional-hazards regression models were used to examine the association between solid fuel use and the incidence or multimorbidity of CMD. The interactions between overweight or obesity and household air pollution on CMD incidence were also investigated. In the present study, solid fuel use from cooking or heating, separately or simultaneously, was positively associated with CMD incidence. Elevated solid fuel use was significantly associated with a higher risk of CMD incidence (HR = 1.25, 95% CI: 1.09, 1.43 for cooking; HR = 1.27, 95% CI: 1.11, 1.45 for heating). A statistically significant interaction between household solid fuel and OW/OB on the incidence of CMD and Cardiometabolic multimorbidity was also observed (p < 0.05). Our findings show that household solid fuel is a risk factor for the incidence of CMD. Therefore, reducing household solid fuel use and promoting clean energy may have great public health value for the prevention of CMD. Full article

Hyperthermia is an internal body temperature increase above 40.5 °C; normally internal body temperature is kept constant through natural homeostatic mechanisms. Heat-related illnesses occur due to exposure to high environmental temperatures in conditions in which an organism is unable to maintain adequate homeostasis. This can happen, for example, when the organism is unable to dissipate heat adequately. Heat dissipation occurs through evaporation, conduction, convection, and radiation. Heat disease exhibits a continuum of signs and symptoms ranging from minor to major clinical pictures. Minor clinical pictures include cramps, syncope, edema, tetany, and exhaustion. Major clinical pictures include heatstroke and life-threatening heat stroke and typically are expressed in the presence of an extremely high body temperature. There are also some categories of people at greater risk of developing these diseases, due to exposure in particular geographic areas (e.g., hot humid environments), to unchangeable predisposing conditions (e.g., advanced age, young age (i.e., children), diabetes, skin disease with reduced sweating), to modifiable risk factors (e.g., alcoholism, excessive exercise, infections), to partially modifiable risk factors (obesity), to certain types of professional activity (e.g., athletes, military personnel, and outdoor laborers) or to the effects of drug treatment (e.g., beta-blockers, anticholinergics, diuretics). Heat-related illness is largely preventable. Full article

Recently, wet-bulb globe temperature (WBGT) has attracted a lot of attention as a useful index for measuring heat strokes even when core body temperature cannot be available for the prevention. However, because the WBGT is only valid in the vicinity of the WBGT meter, the actual ambient heat could be different even in the same room owing to ventilation, clothes, and body size, especially in hot specific occupational environments. To realize reliable heat stroke prevention in hot working places, we proposed a new personalized vital sign index, which is combined with several types of vital data, including the personalized heat strain temperature (pHST) index based on the temperature/humidity measurement to adjust the WBGT at the individual level. In this study, a wearable device was equipped with the proposed pHST meter, a heart rate monitor, and an accelerometer. Additionally, supervised machine learning based on the proposed personalized vital index was introduced to improve the prevention accuracy. Our developed system with the proposed vital sign index achieved a prevention accuracy of 85.2% in a hot occupational experiment in the summer season, where the true positive rate and true negative rate were 96.3% and 83.7%, respectively. Full article

Nowadays, every large enterprise is concerned about reducing CO₂ emissions. Along with legislation, management, packaging, and transportation decisions, optimising the operation of automated systems in the industry is important. Overheating processes or large cooling systems of one machine during product assembly may seem minor but at the industry level it is quite significant. Either an optimisation of cooling systems or an intelligent machine control which will prevent heat strokes and allow the transition to passive cooling of the whole system is an important issue for improving machine tools efficiency and contributing therefore to CO₂ reduction in the industry sector. This research is a transitional phase from the creation of a control system to solve the problems of resonance in the control of systems with parallel piezo kinematics, which were designed to automate the iterative process of non-circular drilling with a precise shape and the subsequent research on the implementation of smart control to optimise the cooling of industrial machines. The total dynamics of the example system in this research is unknown and consists of the dynamics of electrical converters, piezo kinematics, and mechanics. The control signal of this system is generated by the model of the system state with assumptions and simplifications in combination with machine learning techniques considering the previous errors of the transient characteristics with the possibility of re-drilling without damaging the workpiece and with possibility of further trainings to eliminate the iterative process in general. Algorithms for further training at different resonances with a drilling depth change for cylinders of internal combustion engines are offered. These algorithms are proposed for accurate transmission of the input signal amplitude even in resonant situations, power optimisation, increase the system efficiency, as well as reducing the carbon footprint when used in industry in specific applications. Full article

In recent years, the incidence of dental erosion caused by the ingestion of acidic foods and drinks, including sports drinks, has been increasing in Japan and elsewhere. Therefore, the problems associated with this injury can no longer be ignored in dental clinical practice. The ingestion of these foods and drinks is important from the viewpoint of overall health and disease prevention. For example, fermented foods, such as Japanese pickles, enhance the nutritional value of foodstuffs and promote the absorption of nutrients into the body, and sports drinks are useful for preventing heat stroke and dehydration. Therefore, eliminating these intakes is not a viable solution. In this paper, we outline the mechanism of dental erosion caused by acidic beverages and also describe the effectiveness of alkaline ionized water (AIW) at preventing acid erosion. Given the fact that the complete elimination of acidic beverage consumption is highly unlikely, remedies such as the use of alkaline ionized water (AIW) may be helpful. Full article

Atrial fibrillation (AF) is the most common age-related cardiac arrhythmia worldwide and is associated with ischemic stroke, heart failure, and substantial morbidity and mortality. Unfortunately, current AF therapy is only moderately effective and does not prevent AF progression from recurrent intermittent episodes (paroxysmal) to persistent and finally permanent AF. It has been recognized that AF persistence is related to the presence of electropathology. Electropathology is defined as structural damage, including degradation of sarcomere structures, in the atrial tissue which, in turn, impairs electrical conduction and subsequently the contractile function of atrial cardiomyocytes. Recent research findings indicate that derailed proteostasis underlies structural damage and, consequently, electrical conduction impairment. A healthy proteostasis is of vital importance for proper function of cells, including cardiomyocytes. Cells respond to a loss of proteostatic control by inducing a heat shock response (HSR), which results in heat shock protein (HSP) expression. Emerging clinical evidence indicates that AF-induced proteostasis derailment is rooted in exhaustion of HSPs. Cardiomyocytes lose defense against structural damage-inducing pathways, which drives progression of AF and induction of HSP expression. In particular, small HSPB1 conserves sarcomere structures by preventing their degradation by proteases, and overexpression of HSPB1 accelerates recovery from structural damage in experimental AF model systems. In this review, we provide an overview of the mechanisms of action of HSPs in preventing AF and discuss the therapeutic potential of HSP-inducing compounds in clinical AF, as well as the potential of HSPs as biomarkers to discriminate between the various stages of AF and recurrence of AF after treatment. Full article

Typical pneumatic soft micro actuators can be manufactured without using heavy driving components such as pumps and power supplies by adopting an independent battery-powered mechanism. In this study, a thermopneumatically operated soft micro bellows actuator was manufactured, and the standalone operation of the actuator was experimentally validated. Thermopneumatic actuation is based on heating a sealed cavity inside the elastomer of the actuator to raise the pressure, leading to deflection of the elastomer. The bellows actuator was fabricated by casting polydimethylsiloxane (PDMS) using the 3D-printed soluble mold technique to prevent leakage, which is inherent in conventional soft lithography due to the bonding of individual layers. The heater, manufactured separately using winding copper wire, was inserted into the cavity of the bellows actuator, which together formed the thermopneumatic actuator. The 3D coil heater and bellows allowed immediate heat transfer and free movement in the intended direction, which is unachievable for conventional microfabrication. The fabricated actuator produced a stroke of 2184 μm, equivalent to 62% of the body, and exerted a force of 90.2 mN at a voltage of 0.55 V. A system in which the thermopneumatic actuator was driven by alkaline batteries and a control circuit also demonstrated a repetitive standalone operation. Full article

Background and Objectives: Exertional heat stroke (EHS) survivors may be more susceptible to subsequent EHS; however, the occurrence of survivors with subsequent EHS episodes is limited. Therefore, the purpose of this study was to evaluate the incidence of participants with repeated EHS (EHS-2+) cases in a warm-weather road race across participation years compared to those who experienced 1 EHS (EHS-1). Materials and Methods: A retrospective observational case series design was utilized. Medical record data from 17-years at the Falmouth Road Race between 2003–2019 were examined for EHS cases. Incidence of EHS-2+ cases per race and average EHS cases per EHS-2+ participant were calculated (mean ± SD) and descriptive factors (rectal temperature (T_RE), finish time (FT), Wet Bulb Globe Temperature (WBGT), age, race year) for each EHS was collected. Results: A total of 333 EHS patients from 174,853 finishers were identified. Sixteen EHS-2+ participants (11 males, 5 females, age = 39 ± 16 year) accounted for 11% of the total EHS cases (n = 37/333). EHS-2+ participants had an average of 2.3 EHS cases per person (range = 2–4) and had an incidence rate of 2.6 EHS per 10 races. EHS-2+ participants finished 93 races following initial EHS, with 72 of the races (77%) completed without EHS incident. Initial EHS T_RE was not statistically different than subsequent EHS initial T_RE (+0.3 ± 0.9 °C, p > 0.050). Initial EHS-2+ participant FT was not statistically different than subsequent EHS FT (−4.2 ± 7.0 min, p > 0.050). The years between first and second EHS was 3.6 ± 3.5 year (Mode: 1, Range: 1–12). Relative risk ratios revealed that EHS patients were at a significantly elevated risk for subsequent EHS episodes 2 years following their initial EHS (relative risk ratio = 3.32, p = 0.050); however, the risk from 3–5 years post initial EHS was not statistically elevated, though the relative risk ratio values remained above 1.26. Conclusions: These results demonstrate that 11% of all EHS cases at the Falmouth Road Race are EHS-2+ cases and that future risk for a second EHS episode at this race is most likely to occur within the first 2 years following the initial EHS incident. After this initial 2-year period, risk for another EHS episode is not significantly elevated. Future research should examine factors to explain individuals who are susceptible to multiple EHS cases, incidence at other races and corresponding prevention strategies both before and after initial EHS. Full article