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Keywords = glyconanomaterials

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2 pages, 178 KiB  
Editorial
Functional Glyconanomaterials
by Jose M. Palomo, M. Carmen Galan and Jose Manuel Garcia-Fernandez
Nanomaterials 2021, 11(10), 2482; https://doi.org/10.3390/nano11102482 - 24 Sep 2021
Cited by 1 | Viewed by 1817
Abstract
Nanotechnology provides a new array of techniques and platforms to study biological processes including glycosystems [...] Full article
(This article belongs to the Special Issue Functional Glyconanomaterials)
14 pages, 4067 KiB  
Review
Glyconanomaterials for Human Virus Detection and Inhibition
by Noelia Losada-Garcia, Carla Garcia-Sanz, Alicia Andreu, Trinidad Velasco-Torrijos and Jose M. Palomo
Nanomaterials 2021, 11(7), 1684; https://doi.org/10.3390/nano11071684 - 26 Jun 2021
Cited by 8 | Viewed by 4515
Abstract
Viruses are among the most infectious pathogens, responsible for the highest death toll around the world. Lack of effective clinical drugs for most viral diseases emphasizes the need for speedy and accurate diagnosis at early stages of infection to prevent rapid spread of [...] Read more.
Viruses are among the most infectious pathogens, responsible for the highest death toll around the world. Lack of effective clinical drugs for most viral diseases emphasizes the need for speedy and accurate diagnosis at early stages of infection to prevent rapid spread of the pathogens. Glycans are important molecules which are involved in different biological recognition processes, especially in the spread of infection by mediating virus interaction with endothelial cells. Thus, novel strategies based on nanotechnology have been developed for identifying and inhibiting viruses in a fast, selective, and precise way. The nanosized nature of nanomaterials and their exclusive optical, electronic, magnetic, and mechanical features can improve patient care through using sensors with minimal invasiveness and extreme sensitivity. This review provides an overview of the latest advances of functionalized glyconanomaterials, for rapid and selective biosensing detection of molecules as biomarkers or specific glycoproteins and as novel promising antiviral agents for different kinds of serious viruses, such as the Dengue virus, Ebola virus, influenza virus, human immunodeficiency virus (HIV), influenza virus, Zika virus, or coronavirus SARS-CoV-2 (COVID-19). Full article
(This article belongs to the Special Issue Functional Glyconanomaterials)
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34 pages, 10917 KiB  
Review
Cyclodextrin-Based Functional Glyconanomaterials
by Gonzalo Rivero-Barbarroja, Juan Manuel Benito, Carmen Ortiz Mellet and José Manuel García Fernández
Nanomaterials 2020, 10(12), 2517; https://doi.org/10.3390/nano10122517 - 15 Dec 2020
Cited by 29 | Viewed by 5706
Abstract
Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for [...] Read more.
Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for their selective functionalization, in combination with “click” multiconjugation procedures, have further leveraged the nanoscaffold nature of these oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly contributed to understand and exploit the interactions between multivalent glycodisplays and carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties of nanomaterials through host–guest strategies. The whole range of capabilities can be enabled through self-assembly, template-assisted assembly or covalent connection of CD/glycan building blocks. This review discusses the advancements made in this field during the last decade and the amazing variety of functional glyconanomaterials empowered by the versatility of the CD component. Full article
(This article belongs to the Special Issue Functional Glyconanomaterials)
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