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Prostate adenocarcinoma (PCa) is a leading cause of mortality. Black males with high-risk PCa have a poorer prognosis compared to white males. Patients with International Society of Urological Pathology (ISUP) Grade Group (GG) 1 and 2 PCa have little potential for metastases post radical prostatectomy. ⁶⁸Gallium prostate specific membrane antigen (⁶⁸Ga-PSMA) PET/CT imaging for metastatic PCa is superior to conventional imaging in staging high-risk PCa. No strong evidence is available to support imaging low-risk patients. We aimed to evaluate the value of ⁶⁸Ga-PSMA PET/CT in black and white South African (BSA and WSA) males with GG1 and 2 PCa at initial staging. We evaluated 25 WSA and 123 BSA males. The image findings were correlated with prostate specific antigen (PSA). PSA levels significantly correlated with both primary tumor and whole-body PSMA-tumor volume (PSMA-TV) and were higher in BSA males. No differences were noted in the occurrence of metastases; however, PSA, seminal vesicle invasion and black race predicted metastases. Our findings suggest higher PSMA expression and tumor burden in BSA with histologically low-risk PCa, and future research with immunohistochemistry evaluation will be essential to confirm these findings. Full article

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) 3U CubeSat mission is a pathfinder to demonstrate technologies for the measurement of Earth’s radiation budget, the quantification of which is critical for predicting the future course of climate change. A specific motivation is the need for lower-cost technology alternatives that could be used for multi-point constellation measurements of Earth outgoing radiation. RAVAN launched 11 November 2016, into a nearly 600-km, Sun-synchronous orbit, and collected data for over 20 months. RAVAN successfully demonstrates two key technologies. The first is the use of vertically aligned carbon nanotubes (VACNTs) as absorbers in broadband radiometers for measuring Earth’s outgoing radiation and the total solar irradiance. VACNT forests are arguably the blackest material known and have an extremely flat spectral response over a wide wavelength range, from the ultraviolet to the far infrared. As radiometer absorbers, they have greater sensitivity for a given time constant and are more compact than traditional cavity absorbers. The second technology demonstrated is a pair of gallium phase-change black body cells that are used as a stable reference to monitor the degradation of RAVAN’s radiometer sensors on orbit. Four radiometers (two VACNT, two cavity), the pair of gallium black bodies, and associated electronics are accommodated in the payload of an agile 3U CubeSat bus that allows for routine solar and deep-space attitude maneuvers, which are essential for calibrating the Earth irradiance measurements. The radiometers show excellent long-term stability over the course of the mission and a high correlation between the VACNT and cavity radiometer technologies. Short-term variability—at greater than the tenths-of-a-Watt/m² needed for climate accuracy—is a challenge that remains, consistent with insufficient thermal knowledge and control on a 3U CubeSat. There are also VACNT–cavity biases of 3% and 6% in the Total and SW channels, respectively, which would have to be overcome in a future mission. Although one of the black bodies failed after four months, the other provided a repeatable standard for the duration of the project. We present representative measurements from the mission and demonstrate how the radiometer time series can be used to reconstruct outgoing radiation spatial information. Improvements to the technology and approach that would lead to better performance and greater accuracy in future missions are discussed. Full article