Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = fluoro-β-methyl-β-nitrostyrenes

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
15 pages, 391 KB  
Article
A Study of Fluorinated β-Nitrostyrenes as Antimicrobial Agents
by King Lo, Hugh Cornell, Gina Nicoletti, Neale Jackson and Helmut Hügel
Appl. Sci. 2012, 2(1), 114-128; https://doi.org/10.3390/app2010114 - 23 Feb 2012
Cited by 19 | Viewed by 8223
Abstract
The effect of variously fluorine-substituted β-methyl-β-nitrostyrenes on their antimicrobial activity was investigated. Their efficacy was determined by minimum inhibition concentration (MIC) in cultures of Gram positive and Gram negative bacteria and a fungus. Highest activity against the Gram negative bacterium, E.coli, was [...] Read more.
The effect of variously fluorine-substituted β-methyl-β-nitrostyrenes on their antimicrobial activity was investigated. Their efficacy was determined by minimum inhibition concentration (MIC) in cultures of Gram positive and Gram negative bacteria and a fungus. Highest activity against the Gram negative bacterium, E.coli, was achieved with 4-fluorine-aryl substituted β-methyl-β-nitrostyrenes, while most compounds gave excellent results against gram positive bacteria. Importantly, the addition of the β-methyl group profoundly enhanced the antibacterial activity of the compounds tested. The comparative KD values for the most potent compounds against E.coli were much lower than those required for the gram positive and fungus counterparts. This investigation illustrated that fluorine substituted nitropropenylarenes have enhanced antimicrobial activity suitable for antibiotic applications. Full article
(This article belongs to the Special Issue Organo-Fluorine Chemical Science)
Show Figures

Graphical abstract

Back to TopTop