Search Results (77)

Religious freedom, the management of religious diversity, and interreligious dialogue are emerging and closely interconnected phenomena. In the context of increasing religious pluralism, policymakers, religious institutions, and other civil society actors and organizations face challenges, particularly as they strive to legitimize their religious, social, and legal positions in contemporary societies. Drawing on 47 interviews with policymakers (N° 10), privileged informants (N° 15), and religious (N° 18) and interreligious leaders (N° 4), conducted as part of the Project Urban Governance of Religious Diversity (2023–2025), this article examines interreligious dialogue, as a social practice shaped by national legal frameworks on religious freedom and local governance mechanisms regulating religious diversity. More specifically, we analyze the three most relevant themes that emerged from the interview material: first, the limitations and opportunities within the current legislative framework, particularly in relation to local administrations’ efforts to complement national regulations and support religious communities in innovative ways; second, critiques of top-down initiatives on interreligious dialogue, wherein institutional priorities sometimes overshadow the voices and needs of religious groups; and finally, the impact of global events, such as the ongoing genocide in Palestine, on interreligious dialogue and established relationships among different faith communities. The article concludes by summarizing the main findings and outlining potential avenues for future research. Full article

Background/Objectives: ALK+ Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma that is characterized by expression of the Anaplastic Lymphoma Kinase (ALK), which is induced by the t(2;5) chromosomal rearrangement, leading to the expression of the NPM-ALK fusion oncogene. Most previous preclinical models of ALK+ ALCL were based on overexpression of the NPM-ALK cDNA from heterologous promoters. Due to the enforced expression, this approach is prone to artifacts arising from synthetic overexpression, promoter competition and insertional variation. Methods: To improve the existing ALCL models and more closely recapitulate the oncogenic events in ALK+ ALCL, we employed CRISPR/Cas-based chromosomal engineering to selectively introduce translocations between the Npm1 and Alk gene loci in murine cells. Results: By inducing precise DNA cleavage at the syntenic loci on chromosome 11 and 17 in a murine IL-3-dependent Ba/F3 reporter cell line, we generated de novo Npm-Alk translocations in vivo, leading to IL-3-independent cell growth. To verify efficient recombination, we analyzed the expression of the NPM-ALK fusion protein in the recombined cells and could also show the t(11;17) in the IL-3 independent Ba/F3 cells. Subsequent functional testing of these cells using an Alk-inhibitor showed exquisite responsiveness towards Crizotinib, demonstrating strong dependence on the newly generated ALK fusion oncoprotein. Furthermore, a comparison of the gene expression pattern between Ba/F3 cells overexpressing the Npm-Alk cDNA with Ba/F3 cells transformed by CRISPR-mediated Npm-Alk translocation indicated that, while broadly overlapping, a set of pathways including the unfolded protein response pathway was increased in the Npm-Alk overexpression model, suggesting increased reactive changes induced by exogenous overexpression of Npm-Alk. Furthermore, we observed clustered expression changes in genes located in chromosomal regions close to the breakpoint in the new CRISPR-based model, indicating positional effects on gene expression mediated by the translocation event, which are not part of the older models. Conclusions: Thus, CRISPR-mediated recombination provides a novel and more faithful approach to model oncogenic translocations, which may lead to an improved understanding of the molecular pathogenesis of ALCL and enable more accurate therapeutic models of malignancies driven by oncogenic fusion proteins. Full article

Religion played a pivotal role in shaping the political and cultural landscape of early China, particularly through the practice of relocating capitals (遷都). The relocation of capitals is an outstanding theme in early Chinese historiography, setting it apart from many other world traditions. In particular, this practice contrasts sharply with the early Mediterranean context, where the city of Rome transitioned from a modest city-state to a world empire and was celebrated as the “eternal city.” By contrast, early Chinese capitals were deliberately transient, their impermanence rooted in strong religious sentiments and pragmatic considerations. Religious and ideological justifications were central to these relocations. The relocation was not merely a logistical or political exercise; it was imbued with symbolic meaning that reinforced the ruler’s legitimacy and divine mandate. Equally important was the way rulers communicated these decisions to the populace. The ability to garner mass support for such monumental undertakings reveals the intricate relationship between political authority and religious practice in early China. These critical moments of migration offer profound insights into the evolving religious landscape of early China, shedding light on how religion shaped early governance and public persuasion. “Capital relocation” served as a means to rearticulate belief, reaffirm the centrality of worship, and restore faith in the ruling order. Drawing on recent archeological discoveries and updated textual and inscriptional scholarship related to the events of Pan Geng and the Zhou relocation to Luoyi, this article re-examines the motif of “capital relocation” as both a historical and historiographical phenomenon unique to early China. Full article

This paper is an attempt to reflect upon the hidden or mysterious logic of love as an ontological and panexperiential phenomenon. In our attempt, we are crossing the fields of philosophy, spirituality, and contemporary research in psi phenomena (also known as paranormal phenomena) and investigating some historical conditions of margins and disputes between the disciplines based on David Ray Griffin’s work, Parapsychology, Philosophy, and Spirituality. In the main part of this paper, we present the aesthetic theory of force by Christoph Menke and follow his rich analyses on the hidden, obscure layers of the soul. Based on these analyses, we present our own thesis on agapeology as being related both to psi phenomena and aesthetic phenomena. Throughout the history of religion and Western science, magical and miraculous events were too often relegated to the domain of faith or superstition and dismissed almost entirely. In the final parts of this paper, we aim to show that using the approaches of synchronicity (C.G. Jung) and ontology of the ground (F.W.J., Schelling) and acknowledging the phenomena known as quantum entanglement (C. Keller), we can postulate an underlying nexus, providing us with an access to the agapeistic effects of what we idiosyncratically call the phenomenon of dark love. Full article

“Moral shocks” are unexpected events or pieces of information that so deeply challenge one’s basic values and sense of the world that they profoundly reorient a person’s understanding of life and even self. Yet those who experience significant moral shocks rarely participate in related activism and instead experience grief as highly privatized and apolitical, a reality that serves the status quo and most powerful. This article considers how religious resources can help metabolize private grief into public lament and catalyze political grievance. Analyzing the rise of gun control activism after an elementary school mass shooting in Nashville, Tennessee, I argue religious resources help metabolize moral shocks into social change in five significant ways: (1) cultivating practiced, purposeful pathos, (2) offering collective lament, (3) building networked resiliency materially and theologically, (4) risking new alliances of accompaniment, and (5) storying hope. This case analysis contributes to a broader claim for political theology: Christianity can be understood as a movement based on a moral shock. This framing then animates practices of care to accompany those in moral distress and help disciple grief into a movement of faith that resists death-dealing political and social policy. Full article

On the occasion of mass religious events, liturgical ceremonies leave the temple and occupy public space. That is the case of the visits of the Pope or World Youth Days. How does architecture approach the ephemeral construction of this space? What architectural strategies can be used? In the city, the roles are inverted, and the exterior public space becomes an interior delimited by streets and facades that contain the assembly of faithful. How can this urban transformation be “designed”? This article presents several architectural strategies materialized in a series of ephemeral religious architecture projects in the city of Madrid: the stands for the visit of the Pope in Santiago Bernabéu Stadium, Plaza de Colón, Plaza de Cibeles, and Cuatro Vientos airfield. Each of these projects, located in very different urban settings, proposes a different architectural approach. It is evident how the architectural project is, in each case, a response to the characteristics of the urban site in which it is located. City and architecture establish a direct and reciprocal relationship, in which the urban form shapes the architecture that hosts the religious event; vice versa, architecture integrates the city, its limits, its streets, and its facades into the project. Full article

This paper explores the phenomenon of lapsing among young Japanese Catholics, highlighting how both local and translocal experiences of Roman Catholicism shape the ebbs and flows of faith for our interlocutors. While global Catholic events such as World Youth Day can reignite faith by fostering a sense of belonging to a larger, global Church, the contrast with the small and socially isolated Catholic community in Japan often precipitates lapsing. This study examines the influence of the New Evangelisation, which promotes active belief and translocal unity, and argues that this movement can both strengthen global Catholic identity and exacerbate feelings of alienation in local, non-Catholic societies. Ultimately, we stress, in the context of Roman Catholicism, that lapsing should not be seen as simply a rupture in faith but as part of a continuous, if turbulent, Catholic identity, mediated by translocal flows of belief and institutional authority. Full article

The aim of this study was to analyse the motivations of the participants of the festivity in honour of Our Lady of Antime in Fafe (located in the north of Portugal) and provide an overview of the tourism opportunities and impacts associated with the event. To this end, the study analysed the main events on the programme for the 2024 edition of this religious festivity. According to the interviews and participant observations, the impact of the religious festivity in honour of Our Lady of Antime on the faithful who participated was evident. For this study, semi-structured face-to-face interviews and participant observations were conducted, and the former were recorded for subsequent content analysis and categorisation. Participant observation was conducted, focusing on the events that occurred during the religious festivity in honour of the Lady of Antime. The limitations of this study relate to the fact that this is a resource that has not yet been explored as a lever for religious tourism in the municipality, although it has received more media attention in recent years. After carrying out this study, it was possible to conclude that the religious festivity in honour of Our Lady of Antime is attracting more and more believers, and that this event has become a resource that is complementary to the basic tourist resources of the destination of Fafe. Full article

Well-annotated gene and genomic sequences serve as a foundation for making inferences in molecular biology and evolution and can directly impact public health. The first SARS-CoV-2 genome was submitted to the GenBank database hosted by the U.S. National Center for Biotechnology Information and used to develop the two successful vaccines. Conserved protein domains are often chosen as targets for developing antiviral medicines or vaccines. Mutation and substitution patterns provide crucial information not only on functional motifs and genome/protein interactions but also for characterizing phylogenetic relationships among viral strains. These patterns, together with the collection time of viral samples, serve as the basis for addressing the question of when and where the host-switching event occurred. Unfortunately, viral genomic sequences submitted to GenBank undergo little quality control, and critical information in the annotation is frequently changed without being recorded. Researchers often have no choice but to hold blind faith in the authenticity of the sequences. There have been reports of incorrect genome annotation but no report that casts doubt on the genomic sequences themselves because it seems theoretically impossible to identify genomic sequences that may not be authentic. This paper takes an innovative approach to show that some SARS-CoV-2 genomes submitted to GenBank cannot possibly be authentic. Specifically, some SARS-CoV-2 genomic sequences deposited in GenBank with collection times in 2023 and 2024, isolated from saliva, nasopharyngeal, sewage, and stool, are identical to the reference genome of SARS-CoV-2 (NC_045512). The probability of such occurrence is effectively 0. I also compile SARS-CoV-2 genomes with changed sample collection times. One may be led astray in bioinformatic analysis without being aware of errors in sequences and sequence annotation. Full article

Currently, digital situational awareness systems are popular in complex infrastructure construction projects. These systems monitor and assess environmental events, progress, resource availability, risks, and other project decision-making variables to support decision-making. However, little is known about how infrastructure construction (IC) professionals who utilize situational awareness systems perceive how they support or hinder situational management. The purpose of this exploratory research is to study, in depth, the relevance, challenges, and adoption of situational management in IC projects using digital systems. The data were collected via semistructured interviews with 21 IC managers and situational awareness management experts from 11 companies involved in railway projects. The main findings indicate that problem-solving improved with situational management in general, especially with digital situational awareness systems. Seizing the possibilities for transparency that accompany digital situational awareness systems helped in discussing emerging problems and making project choices. Expectations about the realism of such expectations were easier to align with historical event data. On the other hand, the informants reported difficulty in motivating contractors to collect situational data in digital form, possibly because of a lack of understanding about the purpose of data collection, the manual nature of data collection, the perceived excessiveness of data collection, or the manual transfer of collected data into digital form. For these reasons, the informants reported limited faith in these systems. A perceived drawback of situational management, whether supported by digital situational awareness systems or not, was its lack of applicability to the realities of a construction site. Systems were designed for project management needs but not tailored to the needs of construction projects. The interviewees’ statements indicate that maintaining situational awareness requires active interaction and constant checking of the provided information, even requiring pressure on the contractors providing the information. This study highlights the need for practical human approaches to effectively use digital situational awareness technologies and situational management in IC. Full article

Clickable nucleosides, most often 5-ethynyl-2′-deoxyuridine (EtU), are widely used in studies of DNA replication in living cells and in DNA functionalization for bionanotechology applications. Although clickable dNTPs are easily incorporated by DNA polymerases into the growing chain, afterwards they might become targets for DNA repair systems or interfere with faithful nucleotide insertion. Little is known about the possibility and mechanisms of these post-synthetic events. Here, we investigated the repair and (mis)coding properties of EtU and two bulkier clickable pyrimidine nucleosides, 5-(octa-1,7-diyn-1-yl)-U (C8-AlkU) and 5-(octa-1,7-diyn-1-yl)-C (C8-AlkC). In vitro, EtU and C8-AlkU, but not C8-AlkC, were excised by SMUG1 and MBD4, two DNA glycosylases from the base excision repair pathway. However, when placed into a plasmid encoding a fluorescent reporter inactivated by repair in human cells, EtU and C8-AlkU persisted for much longer than uracil or its poorly repairable phosphorothioate-flanked derivative. DNA polymerases from four different structural families preferentially bypassed EtU, C8-AlkU and C8-AlkC in an error-free manner, but a certain degree of misincorporation was also observed, especially evident for DNA polymerase β. Overall, clickable pyrimidine nucleotides could undergo repair and be a source of mutations, but the frequency of such events in the cell is unlikely to be considerable. Full article

After the rise of logical positivism, even in the realm of theology, there was a trend to give up on accepting the actions of God in history as objective acts and to create an atmosphere of separating faith and reason. Wolfhart Pannenberg’s work presents a compelling integration of theology with the rational and empirical rigors of the scientific age. Through a comprehensive theological method, he aimed to establish a dialogue between faith and scientific inquiry, challenging the exclusivity of logical positivism by proposing a theological metaphysics grounded in the concept of retroactive ontology. Pannenberg’s approach is distinguished by its systematic application of hermeneutics, considering the totality of history as the context for divine revelation, and positioning the resurrection of Jesus Christ as a pivotal event that embodies God’s influence on the world. His innovative ontology, which enables one to consider divine action as objective, seeks to validate theology as a science, engaging with natural sciences to foster a mutual enrichment between faith and reason. Pannenberg’s methodological rigor and metaphysical framework offer a robust foundation for a theology that is both intellectually defensible and deeply rooted in Christian faith, advocating for a theology of nature that reconciles the divine with the empirical world. Full article

The media often limit religious coverage to reporting on statements, appointments, opinions, and activities, ignoring in-depth treatment and emphasizing negative news. Media, rather than helping to combat prejudice and promote understanding between communities, have contributed to fuelling intolerance towards religious communities. This study aims to contribute to the understanding of the presence and treatment of religious issues. Through a combination of content analysis focused on Catalan media publications between 1 January 2020 and 31 December 2021, and a focus group with 12 journalists specialized in religious coverage for Catalan newspapers, this research sheds light on the prevailing trends, seeking to answer what is the space of religious content, which can include both content messages produced by religious communities that refer to their own or other faiths and/or content that discusses issues related to religions or religious groups. Occupies in the media agenda, how this content is addressed, and which are the perceptions of journalists regarding the coverage of religious issues. Moreover, we seek to unveil potential actions needed to improve it. The results of this study suggest that there is a tendency to publish limited religious content in the media, potentially shaping perceptions of religion. Furthermore, when religious topics are covered, they focus on Catholicism and Islam, marginalizing other faiths. What is more, stereotypes and misconceptions persist, which could be due to their continued priority to cover scandalous or negative events related to religion. Full article

In the past, popular Catholicism in Latin America and the Caribbean was perceived with suspicion by liberation theologians and official Roman Catholicism for its eccentricities, lack of doctrinal coherence, and fears of syncretism with folk religions. Nowadays, popular Catholicism in Latin America and the Caribbean has been a source of theological reflection, ecumenism, and religious revitalization. The apparition of the Holy Mother in 1953 at barrio Rincón in Sabana Grande, Puerto Rico, is a case study in global Catholicism that exemplifies this turn to see popular Catholicism as a source of liberation, perseverance, and deep spiritual devotion by the faithful. Using cultural, social, and reception historiography, the article argues that the Puerto Rican faithful were not passive recipients of the literary narratives of journalists covering the events as narrated by the main protagonists, the children/seers, but rather themselves formulators of history through their reception and participation. This is demonstrated by the allegiances of the faithful to popular Catholicism and their rejection of the official mandates of the clergy to ignore the events taking place at barrio Rincón regarding the apparition of the Virgin. Full article

Spirituality can be a crucial resource to draw on to make sense of critical situations that mark a turning point in individual and collective biographies. In these cases, a ritual and symbolic response to the trauma may occur, bringing to the surface a «latent spirituality», that is, a tacit propensity towards the sacred that manifests itself in unexpected ways, even in those who do not normally believe or practice, in extraordinary situations that engender fear, anomie or disorientation and that have profound existential repercussions. This article aims to investigate the latent spirituality in the face of the critical event represented by the onset of severe disease, based on the analysis of spiritual illness narratives collected in Italy through qualitative interviews with oncological patients. The narratives show how the condition of suffering can bring to light an unexpressed spirituality, consisting of the revitalization of previous traditional faith or the elaboration of an innovative lay spirituality. Data confirm how pathology constitutes a biographical fracture, accompanied by questions and needs of a religious and spiritual nature. In contrast to the prevailing approach in the medical humanities where spirituality is interpreted as a starting resource to which sufferers resort to cope toward the disease, these results indicate that the spiritual dimension is an emerging aspect along the therapeutic pathway and that it is transformed by reflecting the temporality of the biographical experience of illness. Full article