Search Results (126)

Inadequate vehicle maintenance management is one of the main causes of road accidents and elevated operating costs in light vehicles. This paper addresses this problem through the development and implementation of a low-cost integrated system for preventive maintenance management and alerts. The device, based on an open-hardware architecture (Arduino Mega 2560), integrates Global Positioning System (GPS) and mobile communication (GSM/LTE) modules to monitor distance traveled in real time and notify the user via SMS about the proximity of critical services such as oil changes, brake inspections, and timing-belt replacements. Its technical contribution lies in the integration of non-intrusive virtual ignition, filtered GPS-based odometry, configurable MicroSD-based persistence, and progressive SMS alert logic into a low-cost aftermarket system for conventional vehicles without OBD-II dependence. Experimental validation was conducted in the city of Guayaquil using a 2012 Hyundai Accent. Field tests were carried out in three scenarios: a dense urban route, a peripheral road, and interurban routes. Results showed satisfactory accuracy with a global average percentage error of 3.98% compared to the vehicle’s odometer and 100% effectiveness in sending alerts under the tested conditions (20/20 events; exact 95% binomial confidence interval: 83.2–100.0%). These results provide strong evidence of technical feasibility for the proposed architecture under the tested conditions in a representative single-vehicle proof-of-concept, while broader cross-vehicle validation remains necessary before generalizing the system to the wider diversity of aging fleets. Full article

Background/Objectives: Injury mechanism and intent are key determinants of patient outcomes in the emergency department, yet their combined effects remain insufficiently understood. Emergency department disposition after injury may differ according to mechanism and intent and may be further influenced by specific mechanism–intent combinations. This study aimed to evaluate the associations of injury mechanism, intent, and their interaction with emergency department disposition and injury severity measured using the International Classification of Diseases-based Injury Severity Score (ICISS). Methods: We conducted a retrospective analysis of injury-related emergency department visits recorded between 1 January 2019 and 31 December 2023. Eligible visits included those with valid arrival and departure timestamps and complete disposition data; records with missing key variables or implausible length of stay were excluded. A total of 1,029,875 visits were analyzed. The primary outcome was emergency department disposition, categorized as discharge, admission, or transfer. Multinomial logistic regression was used to estimate relative risk ratios, with discharge as the reference category, and to derive predicted probabilities for selected mechanism–intent combinations. Injury severity was assessed using ICISS and modeled with injury mechanism, intent, their interaction, and prespecified covariates. Results: Of all visits, 69.9% resulted in discharge, 24.3% in admission, and 5.8% in transfer. Compared with traffic accidents, the highest likelihood of admission was observed in suffocation, drowning, and poisoning injuries. Transfer was more frequent in drowning, suffocation, penetrating injuries, and poisoning. Self-harm was associated with increased risks of both admission and transfer compared with unintentional injuries. Interaction analyses showed that certain combinations, particularly poisoning with self-harm and suffocation with self-harm, were associated with substantially higher risks than either factor alone. Predicted probabilities further highlighted high-risk combinations, including markedly elevated admission probabilities in self-harm-related poisoning and suffocation, and increased transfer probability in unintentional drowning. Injury mechanism, intent, and selected interactions were also significantly associated with ICISS-based injury severity. Conclusions: Injury mechanism and intent are independently associated with emergency department disposition and injury severity, with additional risk amplification observed for specific combinations. These findings suggest that mechanism–intent combinations may serve as clinically useful risk indicators in emergency department triage and decision-making, supporting improved risk stratification and system-level coordination. Full article

Autonomous tractors have been shown to possess the capability to ensure a high degree of operational precision during seeding activities on flat terrain. However, in topographically challenging environments characterised by significant elevations and pronounced variations in slope, factors such as road gradients have been shown to compromise the precision of satellite-based positioning systems. This, in turn, can lead to alterations in vehicle posture and the generation of disparate longitudinal driving forces between the left and right tyres. It is important to note that this deviation from the predefined path has the potential to result in rollover accidents. Evidence has been presented that indicates a correlation between road gradient and vehicle roll motion. The proposed methodology is an algorithmic approach to the estimation of lateral slope, integrating inertial measurement unit (IMU) sensors and ground-based ultrasonic radars. This algorithmic approach is proposed as a means to achieve more accurate estimations of lateral slope. The initial development of the vehicle dynamics model was based on slope operation requirements, and the model was endowed with eight degrees of freedom. The utilisation of an unscented Kalman filter (UKF) facilitates the integration of inertial measurement unit (IMU) and ground-based ultrasonic radar measurements, thereby enabling real-time estimation of key motion states, such as lateral slope. The validity of the proposed algorithm was established through a combination of hardware-in-the-loop testing and field trials involving real tractors. The findings indicate that the implementation of this algorithm leads to a substantial enhancement in the trajectory tracking accuracy of tractors during slope operations. This enhancement is characterised by a substantial reduction in lateral deviation and an effective augmentation in the operational pass rate. In the course of empirical trials conducted in a mountainous environment, the lateral positioning deviation during straight-line driving was diminished from 10 cm to within 5 cm. Concurrently, the precision of lateral slope estimation was enhanced to 0.04 degrees. Full article

Background: Red blood cell distribution width (RDW) is an accessible prognostic biomarker in cardiovascular disease, but its independent association with clinical outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) remains incompletely characterized, particularly regarding its prognostic value independent of anemia status. Methods: Using the TriNetX US Collaborative Network (70 healthcare organizations; >105 million patients), we identified 84,811 adult AMI patients who underwent PCI between January 2019 and December 2023 and had RDW measured on the index date. Patients were stratified by RDW ≥ 13.5% (high) versus <13.5% (low) and matched 1:1 using propensity scores based on 38 baseline characteristics. The primary outcome was 1-year all-cause mortality, assessed using a 30-day landmark approach. Secondary outcomes included major adverse cardiovascular events (MACE), heart failure, cardiogenic shock, recurrent AMI, cerebrovascular accident, ventricular tachycardia/fibrillation, and cardiac arrhythmia. Results: After matching (32,010 pairs), high RDW was significantly associated with increased 1-year all-cause mortality (HR 1.77, 95% CI 1.62–1.93, p < 0.001). High RDW was also associated with greater risks of MACE (HR 1.12), heart failure (HR 1.24), cardiogenic shock (HR 1.26), recurrent AMI (HR 1.11), cerebrovascular accident (HR 1.16), and cardiac arrhythmia (HR 1.14; all p < 0.01). Findings remained consistent across serial sensitivity analyses and subgroup analyses. Among non-anemic patients, high RDW remained strongly associated with mortality (HR 1.67, 95% CI 1.50–1.85, p < 0.001). Conclusions: Elevated RDW at the time of AMI is independently associated with mortality and adverse cardiovascular outcomes after PCI, including among non-anemic patients. RDW may serve as a readily available tool to support early risk stratification in this population. Full article

Traffic accidents at urban intersections represent a major road safety concern, particularly those caused by traffic signal violations. To analyze accident mechanisms and develop effective prevention strategies, this study employs a cellular automata model to investigate the relationship between accident probability $P_{ac}$ and traffic parameters at signalized intersections. Simulation results reveal a nonlinear relationship between Pac and traffic demand. The accident probability reaches a maximum under free-flow conditions and subsequently decreases as congestion increases, eventually stabilizing at a nearly constant level under highly congested traffic. Additionally, collision risk increases with lane-changing probability $P_{chg}$, especially upstream of the intersection. High traffic speeds significantly elevate both accident probability and severity. Finally, the results indicate that extending traffic signal cycle durations is not an effective strategy for reducing accident risk. Overall, the proposed model provides a useful framework for estimating accident risk under different traffic conditions and supporting traffic management, including control decisions aimed at improving road safety. Full article

Background and Objectives: Pelvic ring injuries with symphyseal disruption are classically associated with high-energy mechanisms such as motor vehicle collisions. Recently, waterslides have emerged as an underrecognized but distinct source of severe pelvic trauma. Waterslide-related pelvic trauma represents a distinct biomechanical entity characterized by a supine or semi-supine body position at splashdown, extreme forced hip abduction, asymmetric lower-limb positioning, and abrupt hydrodynamic deceleration. The high descent velocity, abrupt hydrodynamic deceleration, and forced hip abduction at water entry may combine to generate open-book-type pelvic injuries. Evidence guiding diagnosis and surgical management in this setting remains scarce. Materials and Methods: We retrospectively analyzed a consecutive series of adult patients sustaining waterslide-related anterior–posterior compression type II (APC2) pelvic ring injuries. Demographic data and the body mass index (BMI), fracture classification, surgical strategy, complications, and functional outcomes were reviewed. Only patients with complete imaging, operative records, and follow-up were included. Results: Four patients (38–72 years) met the inclusion criteria. All sustained rotationally unstable open-book pelvic injuries and were classified as APC2; three were AO/OTA 61B2.3 and one 61B3.3. All patients were overweight or obese (BMI 27.2–31.2). Pelvic binders provided an effective acute reduction in symphyseal diastasis; however, in one bilateral injury, CT imaging obtained with the binder in situ masked posterior ligamentous instability. Definitive surgical fixation was performed in all cases. Early mechanical failure occurred in two patients treated with short anterior symphyseal plate constructs. In the bilateral injury, isolated anterior fixation failed repeatedly until posterior sacroiliac stabilization was added. No deep infections or thromboembolic events occurred. Although two patients required short observational ICU stays, none were admitted for hemodynamic instability or pelvic bleeding. Conclusions: At 12-month follow-up, three patients achieved pain-free ambulation without assistive devices, while one patient required intermittent use of a single crutch; all patients regained independence in daily activities. Waterslide accidents represent a high-energy injury mechanism capable of producing severe APC2 pelvic disruptions, particularly in patients with an elevated BMI. Awareness of this mechanism and meticulous assessment of posterior stability are essential to avoid under-treatment and mechanical failure. Full article

This study presents a comprehensive numerical simulation of reservoir dam failure based on the two-dimensional hydrodynamic model MIKE 21. To reproduce the real accident process, a detailed digital elevation model derived from LiDAR survey data was constructed, incorporating valley microtopography, river channel geometry, and hydraulic structure elements. The modeling was performed in a stepwise manner and included the simulation of breach formation using a time-varying digital elevation model, the drawdown of the reservoir, and the propagation of the dam-break flood wave in the downstream reach, as well as an assessment of the hydrodynamic impact of the flow on small dams located further downstream. The simulations produced spatiotemporal distributions of flow depths and velocities, quantified the temporal evolution of reservoir water volume, and determined overflow parameters at the small dams. Based on the analysis of bed shear stress distribution, zones of increased hydrodynamic loading were identified and compared with observed damage areas. The results confirm the applicability of the adopted modeling framework for detailed reconstruction of dam-break events. The proposed approach can be applied both to the analysis of past dam failures and for predictive purposes when assessing the potential consequences of possible accidents at other reservoirs. The methodology enables preliminary evaluation of inundation zones, erosion intensity, and impacts on downstream hydraulic structures, making it a valuable tool for safety assessment and the planning of protective measures in areas with complex terrain conditions. Full article

Emerging evidence highlights a strong association between cerebrovascular accident (CVA) and major depressive disorder (MDD), mediated by immune dysregulation. Elevated levels of proinflammatory cytokines, reduced adaptive immune responses, altered immune cell composition, and increased microglial activation characterize this bidirectional relationship. Microglial activation appears to be a central molecular mechanism linking CVA and MDD, underscoring the immune system’s crucial role in disease pathogenesis. This interplay suggests that immune-driven processes not only exacerbate neurological damage but also contribute to psychiatric manifestations. Based on current literature, the role of proinflammatory processes, particularly microglial activation, in the relationship between CVA and MDD warrants special attention. In this context, the participation of myeloid differentiation factor 88 (MyD88), a cytosolic adaptor protein, appears to play a key role in proinflammatory signaling pathways driving microglial activation. Thus, focusing on MyD88 emerges as a promising complementary strategy for future research and for advancing our understanding of the mechanisms underlying microglial homeostasis dysregulation and its link to the pathophysiology of MDD and CVA. Full article

This study estimates the levels of chemical contamination and the responses of biochemical and cytogenetic biomarkers in Unio pictorum from the Nemunas River after a large-scale fire at a tire storage and processing warehouse (in October 2019), as well as after the subsequent discharge of partially cleaned water used for firefighting. The impact of firefighting water (FW) on the River Nemunas ecosystem was assessed. Elevated levels of trace metals (Pb, Cu, Co, Cr, Al, Zn) in U. pictorum mussels collected downstream from the wastewater treatment plant (WTP) discharger were measured in the first year after the accident. Genotoxic aberrations in gill cells were significantly more frequent in mussels collected downstream of the WTP discharger, along with higher frequencies of cytotoxic damage and changes in acetylcholinesterase activity. PAH metabolite concentrations, including naphthalene (Nap) and benzo(a)pyrene (B(α)P), were also elevated in haemolymph in U. pictorum gathered downstream from the discharger, but differences were not statistically significant. The total sum of 16 PAH concentrations in mussels collected in 2021 and 2022 was over 5 times higher than those in 2020, and the profile of accumulated metals shifted, with Ni, Cd, Cr, and Pb concentrations decreasing while Zn increased significantly. Mussel haemolymph in 2021 contained the highest levels of B(α)P-type PAH metabolites, indicating increased oxidative stress and neurotoxic impact. The results of chemical analysis and the values of genotoxic aberrations determined in gill cells of U. pictorum collected in 2021 and 2022 indicate an increase in PAH contamination and geno-cytotoxic impact compared to the results of 2020; these changes might be related to the gradual cancellation of COVID-19 restrictions and restoration of routine activities. The study provided an opportunity to demonstrate the unique response of a less anthropogenically stressed ecosystem to the extreme impact of contamination related to the fire on the tire recycling plant. Full article

The research and development of new accident-tolerant fuel cladding materials has emerged as a critical focus in international academic and engineering fields following the Fukushima nuclear accident. Due to the outstanding resistances in corrosion and radiation as well as high-temperature creep properties, oxide dispersion-strengthened (ODS) FeCrAl alloys have been studied extensively during the past decade. Current review articles in this field have primarily focused on the effects of chemical composition on the anti-corrosion performance and species of nano-oxide. However, several key issues have not been given adequate attention, including processing methods and parameters, high-temperature stability mechanisms, post-deformation microstructural evolution and high-temperature mechanical properties. This paper reviews the progress of basic research on ODS FeCrAl alloys, including preparation methods, the effects of preparation parameters, the thermal stability and irradiation stability of oxides, the microstructural deformation, and the mechanical properties at elevated temperatures. The aspects mentioned above not only provide valuable references for understanding the effects of preparation parameters on the microstructure and properties of ODS FeCrAl alloys but also offer a comprehensive framework for the subsequent optimization of ODS FeCrAl alloys for nuclear reactor applications. Full article

This paper analyzes the dynamic behavior of a passenger bus running on a raised crosswalk. The main objective was to evaluate the vertical displacements and accelerations caused by the change in elevation, and to determine the potential for suspension damage. The study involved a numerical approach to the examination of a vehicle’s displacement related to the profile pavement by the implementation of a single body finite element module with suspension subjected to the effect of road unevenness. The so-obtained dynamic behavior with this model was implemented in MATLAB software, and the results were compared with the corresponding real-world accident data record and with an experimental study carried out with a bus running on a raised crosswalk at prescribed velocities. The velocity on the day of the accident was then calculated by computational simulations using the software PC-Crash^®. The results show that the vertical displacement caused by the raised crosswalk can vary according to the bus velocity and the raised crosswalk height. Moreover, the results show that reducing the height of the raised crosswalk and redesigning it for a smoother transition with the pavement can help in minimizing the negative effects from impacts on the bus body. The findings of this study provide valuable insights for engineers and transportation planners, and can be used to improve the design and placement of raised crosswalks in the future. Full article

The ship recycling industry in Bangladesh has transformed from informal, beaching-based operations into a globally significant sector, representing over 45% of global recycling tonnage and providing essential raw materials and employment opportunities. This study adopts a mixed-methods design, combining secondary data analysis (2014–2024 gross tonnage records), over 500 stakeholder interviews, and ARIMA-based scenario forecasting up to 2050. The findings indicate that the sector contributes approximately USD 2.1 billion annually to the national economy and supports more than 250,000 direct and indirect jobs. Despite its economic significance, major compliance gaps persist with the Hong Kong International Convention (HKC): only about 52% of yards are certified or in the process of certification. Workplace accident rates remain roughly 30% higher than regional averages, while environmental assessments reveal elevated heavy metal concentrations in soil and water, underscoring weak regulatory enforcement and environmental management. Comparative analysis shows that India has successfully modernized over 120 HKC-compliant yards through targeted policy and financial incentives, whereas Pakistan is rapidly upgrading its Gadani facilities through major investment programs. Forecasting results identify three trajectories: a baseline of ~2.7 million GT annually to 2050, an optimistic expansion to ~5 million GT with green reforms, and a pessimistic decline below 2 million GT if progress stagnates. To ensure sustainable advancement, five strategic policy pillars are proposed, offering an evidence-based roadmap for Bangladesh to achieve safe, environmentally sound, and globally competitive ship recycling. Full article

As an essential highway safety facility, roadside W-beam guardrails effectively prevent errant vehicles from entering hazardous zones or causing secondary collisions by blocking and redirecting them, thereby reducing accident severity. With the rapid development of the automotive industry, the front bumper height of small passenger cars generally ranges between 405 mm and 485 mm. However, the lower edge height of the current Chinese Class A W-beam guardrail is 444 mm above the ground, which leads to a high risk of “underride” during collisions, resulting in elevated occupant injury risks. To address this issue, this paper proposes an optimized guardrail structure composed of a double W-beam and a C-type beam, aiming to reduce the underride risk for small passenger cars while accommodating multi-vehicle protection needs. In this design, the double W-beam is installed at a height of 560 mm and the C-type beam at 850 mm, connected to circular posts using a regular hexagonal anti-obstruction block. The beam thickness is uniformly 3 mm, while the thickness of other components is 4 mm. To systematically evaluate the impact of material strength on both safety performance and cost, two material configurations are proposed: Scheme 1 uses Q235 carbon steel for all components; Scheme 2 reduces the thickness of the C-type beam to 2.5 mm and employs Q355 high-strength low-alloy steel, with the thickness of the connected anti-obstruction block reduced to 3.5 mm, while the other components retain Q235 steel and unchanged structural dimensions. Using finite element simulation, collisions involving small passenger cars, medium trucks, and buses are simulated, and performance comparisons are conducted based on vehicle trajectory and guardrail deformation. For the small passenger car scenario, risk quantification indicators—Acceleration Severity Index (ASI), Theoretical Head Impact Velocity (THIV), and Post-impact Head Deceleration (PHD)—are introduced to assess occupant injury. The results demonstrate that Scheme 2 not only meets the required protection level but also significantly reduces occupant risk for small passenger cars, lowering the injury rating from Class C to Class B. Moreover, the overall structural mass is reduced by approximately 1407 kg per kilometer, with material costs decreased by about RMB 10,129, demonstrating favorable economic efficiency. The proposed structural optimization not only effectively mitigates small car underride and improves multi-vehicle protection performance but also provides the industry with a novel guardrail geometric design directly applicable to engineering practice. The technical approach of enhancing material strength and reducing component thickness also offers a feasible reference for lightweight design, material savings, and cost optimization of guardrail systems, contributing significantly to improving the safety and sustainability of road transportation infrastructure. Full article

Current coal mine fire risk assessments often rely on static models and isolated factors, failing to capture the complex, dynamic interactions that lead to fires. To address this gap, we propose a comprehensive framework—termed INK-FBSD—integrating Interpretive Structural Modeling (ISM), the NK model, fuzzy Bayesian network analysis, and System Dynamics (SD) simulation. Using ISM, we identified and hierarchically structured 31 risk factors across human, equipment, environment, management, and fire protection domains, revealing that a robust mine safety accountability system is a pivotal root factor. The NK model quantifies how accident likelihood escalates as more factors interact—for example, four-factor couplings (e.g., equipment–environment–management–fire protection) yield significantly higher risk indices (T ≈ 0.34) than two-factor scenarios. The fuzzy Bayesian analysis estimates an overall 46% probability of a fire accident under current conditions, and diagnostic inference pinpoints excessive coal dust accumulation and neglected fire prevention as top contributors when an incident occurs (posterior probabilities 83% and 78%, respectively). Finally, SD simulations show how key risk factors (such as equipment failure and maintenance delays) can rapidly elevate to severe risk levels within 9–15 months without intervention, underscoring the need for continuous monitoring and proactive control. In summary, the INK-FBSD approach provides a multidimensional understanding of coal mine fire mechanisms and delivers practical guidance for safety management by prioritizing critical risk factors, anticipating high-risk coupling pathways, and informing more effective fire prevention and emergency response strategies. Full article

Programmed cell death (PCD), a regulated cell death (RCD) subtype essential for physiological homeostasis, encompasses distinct mechanisms including apoptosis, necroptosis, autophagy, ferroptosis, cuproptosis, and pyroptosis. This evolutionarily conserved process critically regulates disease pathogenesis across degenerative disorders, malignancies, fungal infections, and vascular calcification (VC). VC manifests as pathological calcium deposition in cardiovascular tissues, impairing vascular elasticity and hemodynamics. These structural alterations elevate risks of atherosclerotic events, cerebrovascular accidents, and peripheral vascular dysfunction, while concomitantly inducing vital organ hypoperfusion and cardiac overload that predispose individuals to myocardial ischemia, left ventricular hypertrophy, and heart failure. Despite advances in delineating associated signaling networks, the molecular etiology of VC remains elusive, and effective therapeutic interventions are currently lacking. While systematically examining the pathophysiological contributions of both established and novel PCD mechanisms to VC progression, this review incorporates a discussion of cuproptosis as a novel form of PCD, which may serve as a target for atherosclerosis treatment. The inclusion of cuproptosis, alongside other PCD modalities, allows for a more integrated and updated perspective on the complex regulatory networks governing VC. Our objective is to synthesize the current understanding of how these diverse PCD pathways, both classical and emerging, collectively contribute to the disease pathogenesis and to explore the broader therapeutic potential of targeting PCD in VC. Full article