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Keywords = azaphenanthrene alkaloid

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7 pages, 432 KiB  
Communication
Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
by Ana Silvia Suassuna Carneiro Lúcio, Jackson Roberto Guedes Da Silva Almeida, José Maria Barbosa-Filho, João Carlos Lima Rodrigues Pita, Marianna Vieira Sobral Castello Branco, Margareth De Fátima Formiga Melo Diniz, Maria De Fátima Agra, Emidio V.L. Da-Cunha, Marcelo Sobral Da Silva and Josean Fechine Tavares
Molecules 2011, 16(8), 7125-7131; https://doi.org/10.3390/molecules16087125 - 22 Aug 2011
Cited by 18 | Viewed by 8352
Abstract
Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. [...] Read more.
Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 µg/mL, respectively. Full article
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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