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Keywords = anthrolysin

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18 pages, 974 KB  
Review
Bacillus anthracis Factors for Phagosomal Escape
by Fiorella Tonello and Irene Zornetta
Toxins 2012, 4(7), 536-553; https://doi.org/10.3390/toxins4070536 - 10 Jul 2012
Cited by 26 | Viewed by 12917
Abstract
The mechanism of phagosome escape by intracellular pathogens is an important step in the infectious cycle. During the establishment of anthrax, Bacillus anthracis undergoes a transient intracellular phase in which spores are engulfed by local phagocytes. Spores germinate inside phagosomes and grow to [...] Read more.
The mechanism of phagosome escape by intracellular pathogens is an important step in the infectious cycle. During the establishment of anthrax, Bacillus anthracis undergoes a transient intracellular phase in which spores are engulfed by local phagocytes. Spores germinate inside phagosomes and grow to vegetative bacilli, which emerge from their resident intracellular compartments, replicate and eventually exit from the plasma membrane. During germination, B. anthracis secretes multiple factors that can help its resistance to the phagocytes. Here the possible role of B. anthracis toxins, phospholipases, antioxidant enzymes and capsules in the phagosomal escape and survival, is analyzed and compared with that of factors of other microbial pathogens involved in the same type of process. Full article
(This article belongs to the Special Issue Anthrax Toxin)
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