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Keywords = ambrinol

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16 pages, 1711 KB  
Article
Liquid Chromatography–Mass Spectrometry-Based Molecular Profiling of Vertigoheel
by Andreas Dunkel, Stephan Duller, Susanne Alban, Michael Strupp and Louisa Lehner
Int. J. Mol. Sci. 2026, 27(4), 1893; https://doi.org/10.3390/ijms27041893 - 16 Feb 2026
Cited by 1 | Viewed by 703
Abstract
Vertigoheel is a multicomponent medicinal product for the treatment of vertigo and dizziness, containing Anamirta cocculus, Conium maculatum, Ambra grisea, and Petroleum rectificatum. Although clinical efficacy has been reported, the chemical composition and underlying mechanisms remain incompletely characterized. Here, [...] Read more.
Vertigoheel is a multicomponent medicinal product for the treatment of vertigo and dizziness, containing Anamirta cocculus, Conium maculatum, Ambra grisea, and Petroleum rectificatum. Although clinical efficacy has been reported, the chemical composition and underlying mechanisms remain incompletely characterized. Here, we applied ultra-high-performance liquid chromatography coupled to time-of-flight mass spectrometry (UHPLC-ToF-MS) to profile extracts of each ingredient and the final formulations. Untargeted analysis revealed 68,622 molecular features, and multivariate statistics highlighted ingredient-specific metabolites. Representative markers included picrotoxinin and picrotin from Anamirta cocculus, coniine and N-methylconiine from Conium maculatum, ambrinol and ambroxide from Ambra grisea, and santalyl phenylacetate and mercaptostearic acid from Petroleum rectificatum. Two compounds per ingredient were further quantified by targeted UHPLC-MS/MS, confirming their presence in drops and tablets at nanogram-per-dose levels with moderate variability across batches. These findings demonstrate that Vertigoheel retains characteristic constituents from its natural sources in all tested formulations. The established protocol enabled absolute quantification of neuroactive molecules such as picrotoxinin and coniine with minimal work-up. This molecular characterization provides new insight into Vertigoheel’s composition and supports further investigation of its mechanism of action using network pharmacology approaches. Full article
(This article belongs to the Section Molecular Pharmacology)
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13 pages, 2678 KB  
Article
A Concise Diastereoselective Total Synthesis of α-Ambrinol
by Josefa L. López-Martínez, Irene Torres-García, Irene Moreno-Gutiérrez, Pascual Oña-Burgos, Antonio Rosales Martínez, Manuel Muñoz-Dorado, Míriam Álvarez-Corral and Ignacio Rodríguez-García
Mar. Drugs 2023, 21(4), 230; https://doi.org/10.3390/md21040230 - 1 Apr 2023
Cited by 4 | Viewed by 4676
Abstract
(−)-cis-α-Ambrinol is a natural product present in ambergris, a substance of marine origin that has been highly valued by perfumers. In this paper, we present a new approach to its total synthesis. The starting material is commercially available α-ionone and the [...] Read more.
(−)-cis-α-Ambrinol is a natural product present in ambergris, a substance of marine origin that has been highly valued by perfumers. In this paper, we present a new approach to its total synthesis. The starting material is commercially available α-ionone and the key step is an intramolecular Barbier-type cyclization induced by CpTiCl2, an organometallic compound prepared in situ by a CpTiCl3 reduction with Mn. Full article
(This article belongs to the Section Synthesis and Medicinal Chemistry of Marine Natural Products)
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