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Keywords = allergenic pollen protein (Pla a3)

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15 pages, 4666 KiB  
Article
Characterization of Microbials in the Lung Induced by Allergenic Platanus Pollen Protein (Pla a3) and Ambient Fine Particulate Matter
by Jin Liu, Senlin Lu, Guoqing Hou, Wenwen Hu, Jiumei Zhao, Wei Zhang, Xinchun Liu, Enyoh Christian Ebere, Weiqian Wang and Qingyue Wang
Atmosphere 2024, 15(4), 503; https://doi.org/10.3390/atmos15040503 - 19 Apr 2024
Cited by 1 | Viewed by 1919
Abstract
Ambient pollen proteins play key roles in the incidence of allergenic respiratory health, and numerous reports have focused on respiratory diseases caused by air pollutants. However, there is still a lack of understanding of the specific mechanisms underlying the involvement of microbiota in [...] Read more.
Ambient pollen proteins play key roles in the incidence of allergenic respiratory health, and numerous reports have focused on respiratory diseases caused by air pollutants. However, there is still a lack of understanding of the specific mechanisms underlying the involvement of microbiota in the respiratory tracts and effects induced by air pollutants. Therefore, an allergenic animal model was established to investigate the characterization of microbials in the lung induced by allergenic Platanus pollen protein (Pla a3) and ambient fine particulate matter. Our data showed that the mice exhibited strong immune and inflammatory responses after being exposed to PMs and Pla a3 protein. This included increased levels of immunoglobulins IgG and IgE, as well as elevated levels of cytokines TNF-α, IFN-γ, IL-4, and IL-13. Furthermore, the amounts of pathogenic bacteria, such as Desulfobacterota, Enterococcus, Ferruginibacter, and Pseudoxanthomonas, in the lung microbiota of the Pla a3 exposure group increased significantly. Correlation analysis revealed a strong association between specific lung bacteria and alterations in cytokines from the lung samples. Probiotic bacteria, Deferribacterota and Bifidobacterium, was associated with changes in the level of IgG and IgE. However, pathogenic bacteria, like Prevotella and Fusobacterium, were linked with the cytokines IL-4 and TNF-α. Full article
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8 pages, 1246 KiB  
Article
Relationships between Mass Level of Allergenic Platanus acerifolia Protein 3 (Pla a3) and Redox Trace Elements in the Size-Resolved Particles in Shanghai Atmosphere
by Senlin Lu, Teng Ma, Lu Zhang, Yule Feng, Shumin Zhou, Wei Zhang, Shinichi Yonemochi, Xinchun Liu, Enyoh Christian Ebere, Weiqian Wang and Qingyue Wang
Atmosphere 2022, 13(10), 1541; https://doi.org/10.3390/atmos13101541 - 21 Sep 2022
Viewed by 1671
Abstract
Allergenic pollen protein can be released from pollen grains and suspended in the air to cause allergenic reactions. However, the allergenic protein and its relationship with redox trace elements in ambient size-resolved particles has not been reported. Ambient size-resolved particles in Shanghai’s atmosphere [...] Read more.
Allergenic pollen protein can be released from pollen grains and suspended in the air to cause allergenic reactions. However, the allergenic protein and its relationship with redox trace elements in ambient size-resolved particles has not been reported. Ambient size-resolved particles in Shanghai’s atmosphere were sampled during the Platanus pollen season in the spring season of 2017. Planatus pollen protein 3 (Pla a3) and redox trace elements in the ambient particles were investigated and their relationship was analyzed. Our data demonstrated that the mass level of the Pla a3 in the size-resolved particles ranged from 0.41 ± 0.28 to 7.46 ± 2.23 pg/m3, and decreased with the size range. Mass concentrations (ppb) of crustal elements (Fe, Al, Ca, Mg, Na) in the size-resolved particles ranged from 20.11 ± 9.87 to 1126.22 ± 659.51, while trace elements (V, Cr, Mn, Co, Ni, Cu, Zn, Ga, As, Se, Rb, Sr, Cd, Cs, Ba, Pb) varied from 0.05 ± 0.03 to 57.53 ± 19.7. Mass levels of these trace elements decreased according to particle size. The Abundance of redox trace elements, including Fe (R2 = 0.82), Mn (R2 = 0.54), Cu (R2 = 0.61), Ba (R2 = 0.82), and Pb (R2 = 0.82) in the size-resolved particles was significantly related to that of Pla a3, and our data implied redox trace elements might take syngenetic effects on the allergenicity induced by Pla a3 protein. Full article
(This article belongs to the Section Air Quality)
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