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Keywords = alkenyl and benzofuran derivatives

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16 pages, 2185 KB  
Article
Undescribed Cyclohexene and Benzofuran Alkenyl Derivatives from Choerospondias axillaris, a Potential Hypoglycemic Fruit
by Ermias Tamiru Weldetsadik, Na Li, Jingjuan Li, Jiahuan Shang, Hongtao Zhu and Yingjun Zhang
Foods 2024, 13(10), 1495; https://doi.org/10.3390/foods13101495 - 11 May 2024
Cited by 2 | Viewed by 1654
Abstract
The fruit of Choerospondias axillaris (Anacardiaceae), known as south wild jujube in China, has been consumed widely in several regions of the world to produce fruit pastille and leathers, juice, jam, and candy. A comprehensive chemical study on the fresh fruits led to [...] Read more.
The fruit of Choerospondias axillaris (Anacardiaceae), known as south wild jujube in China, has been consumed widely in several regions of the world to produce fruit pastille and leathers, juice, jam, and candy. A comprehensive chemical study on the fresh fruits led to the isolation and identification of 18 compounds, including 7 new (17) and 11 known (818) comprised of 5 alkenyl (cyclohexenols and cyclohexenones) derivatives (15), 3 benzofuran derivatives (68), 6 flavonoids (914) and 4 lignans (1518). Their structures were elucidated by extensive spectroscopic analysis. The known lignans 1518 were isolated from the genus Choerospondias for the first time. Most of the isolates exhibited significant inhibitory activity on α-glucosidase with IC50 values from 2.26 ± 0.06 to 43.9 ± 0.96 μM. Molecular docking experiments strongly supported the potent α-glucosidase inhibitory activity. The results indicated that C. axillaris fruits could be an excellent source of functional foods that acquire potential hypoglycemic bioactive components. Full article
(This article belongs to the Section Nutraceuticals, Functional Foods, and Novel Foods)
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