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Keywords = Sarcophyton cinereum

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9 pages, 1862 KiB  
Article
Isosarcophytoxide Derivatives with a 2,5-Dihydrofuran Moiety from the Soft Coral Sarcophyton cinereum
by Chih-Hua Chao, Yuan-Jhong Wu, Tzu-Yin Huang, Chi-Jen Tai, Yi-Ju Chen, Chiung-Yao Huang, Chi-Chien Lin, Chang-Feng Dai, Hui-Chi Huang and Jyh-Horng Sheu
Molecules 2023, 28(2), 641; https://doi.org/10.3390/molecules28020641 - 8 Jan 2023
Cited by 3 | Viewed by 2090
Abstract
The present chemical investigation on the organic extract of the soft coral Sarcophyton cinereum has contributed to the isolation of four new cembranoids: 16β- and 16α-hydroperoxyisosarcophytoxides (1 and 2), 16β- and 16α-methoxyisosarcophytoxides ( [...] Read more.
The present chemical investigation on the organic extract of the soft coral Sarcophyton cinereum has contributed to the isolation of four new cembranoids: 16β- and 16α-hydroperoxyisosarcophytoxides (1 and 2), 16β- and 16α-methoxyisosarcophytoxides (3 and 4), and a known cembranoid, lobocrasol (5). The structures of all isolates were elucidated by detailed spectroscopic analysis. Their structures were characterized by a 2,5-dihydrofuran moiety, of which the relative configuration was determined by DU8-based calculation for long-range coupling constants (4JH,H). The cytotoxicity and immunosuppressive activities of all isolates were evaluated in this study. Full article
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11 pages, 2709 KiB  
Article
Cembranolides and Related Constituents from the Soft Coral Sarcophyton cinereum
by Chih-Hua Chao, Yi-Ju Chen, Chiung-Yao Huang, Fang-Rong Chang, Chang-Feng Dai and Jyh-Horng Sheu
Molecules 2022, 27(6), 1760; https://doi.org/10.3390/molecules27061760 - 8 Mar 2022
Cited by 6 | Viewed by 2430
Abstract
In an attempt to explore the bioactive metabolites of the soft coral Sarcophyton cinereum, three new cembranolides, cinerenolides A–C (13), and 16 known compounds were isolated and identified from the EtOAc extract. The structures of the new cembranolides [...] Read more.
In an attempt to explore the bioactive metabolites of the soft coral Sarcophyton cinereum, three new cembranolides, cinerenolides A–C (13), and 16 known compounds were isolated and identified from the EtOAc extract. The structures of the new cembranolides were elucidated on the basis of spectroscopic analysis, and the NOE analysis of cinerenolide A (1) was performed with the assistance of the calculated lowest-energy molecular model. The relative configuration of cinerenolide C (3) was determined by the quantum chemical NMR calculation, followed by applying DP4+ analysis. In addition, the cytotoxic assays disclosed that some compounds exhibited moderate to potent activities in the proliferation of P388, DLD-1, HuCCT-1, and CCD966SK cell lines. Full article
(This article belongs to the Special Issue Innovative Marine Molecules: Chemistry, Biology and Analysis)
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