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Keywords = Saccharothrix sp.

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12 pages, 1832 KiB  
Article
Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert
by Rishi Vachaspathy Astakala, Gagan Preet, Bruce F. Milne, Julius Tibyangye, Valeria Razmilic, Jean Franco Castro, Juan A. Asenjo, Barbara Andrews, Rainer Ebel and Marcel Jaspars
Molecules 2022, 27(21), 7185; https://doi.org/10.3390/molecules27217185 - 24 Oct 2022
Cited by 4 | Viewed by 3235
Abstract
Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial [...] Read more.
Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against Enterococcus pseudoavium and Staphylycoccus Aureus subsp. Aureus. Full article
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10 pages, 1707 KiB  
Article
Seco-Tetracenomycins from the Marine-Derived Actinomycete Saccharothrix sp. 10-10
by Bin Liu, Jiao Li, Minghua Chen, Xiaomeng Hao, Fei Cao, Yi Tan, Yuhui Ping, Yiguang Wang, Chunling Xiao and Maoluo Gan
Mar. Drugs 2018, 16(10), 345; https://doi.org/10.3390/md16100345 - 20 Sep 2018
Cited by 9 | Viewed by 4353
Abstract
Six new tetracenomycin congeners, saccharothrixones E–I (15) and 13-de-O-methyltetracenomycin X (6), were isolated from the rare marine-derived actinomycete Saccharothrix sp. 10-10. Their structures were elucidated by spectroscopic analysis and time-dependent density functional theory (TDDFT)-electronic circular [...] Read more.
Six new tetracenomycin congeners, saccharothrixones E–I (15) and 13-de-O-methyltetracenomycin X (6), were isolated from the rare marine-derived actinomycete Saccharothrix sp. 10-10. Their structures were elucidated by spectroscopic analysis and time-dependent density functional theory (TDDFT)-electronic circular dichroism (ECD) calculations. Saccharothrixones G (3) and H (4) are the first examples of tetracenomycins featuring a novel ring-A-cleaved chromophore. Saccharothrixone I (5) was determined to be a seco-tetracenomycin derivative with ring-B cleavage. The new structural characteristics, highlighted by different oxidations at C-5 and cleavages in rings A and B, enrich the structural diversity of tetracenomycins and provide evidence for tetracenomycin biosynthesis. Analysis of the structure–activity relationship of these compounds confirmed the importance of the planarity of the naphthacenequinone chromophore and the methylation of the polar carboxy groups for tetracenomycin cytotoxicity. Full article
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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