Search Results (8)

On 4 September 2024, the Reagan-Udall Foundation for the FDA (FDA Foundation) in collaboration with the Food and Drug Administration (FDA) and the Gates Foundation hosted a workshop titled “Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence”. The event brought together a diverse group of experts, including international regulatory bodies, regulated industries, healthcare professionals, patients, academic researchers and global health advocates, to discuss the rapid advancements in gene therapy and the pressing need for equitable access in low-and middle-income countries (LMICs), with sickle cell disease (SCD) serving as the model disorder for the discussions. Although there has been significant progress in gene therapy, such as breakthroughs in clustered regularly interspaced short palindromic repeats (CRISPR)-based technologies and FDA-approved therapies, access to these therapies remain limited in underresourced regions. The workshop addressed critical challenges, including the high cost of therapies, regulatory gaps and barriers and ethical concerns regarding informed consent and public engagement in LMICs. This paper highlights the critical discussion points from the workshop with a focus on exploring strategies for global regulatory convergence, the role of international collaborations and the potential pathways to making gene therapies affordable and accessible to all. Full article

In November 1986, a Lebanese weekly published an article stating that high level officials within the administration of U.S. President Ronald Reagan had sold weapons to an embargoed Iran and diverted the profits to counterrevolutionary forces fighting the government of Nicaragua. Both of these facts violated domestic and international law. What ensued was the Iran-Contra scandal that almost ended Reagan’s presidency and jeopardized the credibility of U.S. foreign policy. Drawing from periodicals from the U.S. and international presses, as well as U.S. Congressional records, this article demonstrates that studies on the origins of Iran-Contra have overlooked one critical cause of the scandal—a lawsuit that Nicaragua presented against the United States at the International Court of Justice in April 1984. While the case “Nicaragua v the United States of America” played an important causal role in the history of the Iran-Contra affair, its importance goes beyond mere causality. As this article demonstrates, the impact that this international lawsuit had on the origins of Iran-Contra elucidates the influence of public opinion on shaping domestic and foreign policy, on the extent to which foreign policy is driven by domestic political realities, and on the importance of international courts as the theaters where battles for legitimacy are waged. Full article

The generation of chrysanthemum (Chrysanthemum × morifolium) flower color is mainly attributed to the accumulation of anthocyanins. Light is one of the key environmental factors that affect the anthocyanin biosynthesis, but the deep molecular mechanism remains elusive. In our previous study, a series of light-induced structural and regulatory genes involved in the anthocyanin biosynthetic pathway in the chrysanthemum were identified using RNA sequencing. In the present study, differentially expressed proteins that are in response to light with the capitulum development of the chrysanthemum ‘Purple Reagan’ were further identified using isobaric tags for relative and absolute quantification (iTRAQ) technique, and correlation between the proteomic and the transcriptomic libraries was analyzed. In general, 5106 raw proteins were assembled based on six proteomic libraries (three capitulum developmental stages × two light treatments). As many as 160 proteins were differentially expressed between the light and the dark libraries with 45 upregulated and 115 downregulated proteins in response to shading. Comparative analysis between the pathway enrichment and the gene expression patterns indicated that most of the proteins involved in the anthocyanin biosynthetic pathway were downregulated after shading, which was consistent with the expression patterns of corresponding encoding genes; while five light-harvesting chlorophyll a/b-binding proteins were initially downregulated after shading, and their expressions were enhanced with the capitulum development thereafter. As revealed by correlation analysis between the proteomic and the transcriptomic libraries, GDSL esterase APG might also play an important role in light signal transduction. Finally, a putative mechanism of light-induced anthocyanin biosynthesis in the chrysanthemum was proposed. This study will help us to clearly identify light-induced proteins associated with flower color in the chrysanthemum and to enrich the complex mechanism of anthocyanin biosynthesis for use in cultivar breeding. Full article

Activists and academics are returning to the 1980s for clues and context concerning the modern Right in the United States, oftentimes with the hope of deriving insights that can be wielded against the legal agenda of the Trump administration. This is a worthwhile historical endeavor, which must not ignore the essential position of feminist legal theorists. This article reveals the foundational role of feminist critical legal scholars, or “Fem-Crits”, to the progressive resistance against conservative legal thought during the 1980s. By highlighting the work of Fem-Crits in the academy and within the critical legal studies movement, this article identifies the Fem-Crits as a valuable source of movement inspiration and theoretical influence for leftist law professors, lawyers, and activists in the twenty-first century. Full article

This article explores the work of welfare-rights activists in 1960s and 70s California. These activists were mostly working-class black and some white mothers, and the majority of them were themselves welfare recipients. As welfare recipients, women of color, and working-class people, they faced a wave of policies and ideologies that stigmatized them, policed their behavior, and made receiving benefits increasingly difficult. These policies were but one element of a larger political crisis, wherein the California government stoked racialized and gendered fears in order to shrink the welfare state. Rather than simply acquiesce to this reality, welfare-rights groups in California refused to accept it. Though scholars have studied welfare-rights groups in Washington, D.C., Nevada, New York, and other US states, almost no attention has been given to groups in California. In this article I use state legislation, newspaper articles, organizational records, and archived interviews to illustrate how California’s welfare-rights movement challenged anti-welfare policy and ideology. I argue that they did more than simply reject punitive legislation. They emphasized childcare, rebuked middle-class complacency, questioned the primacy of the nuclear family, and dismissed gender roles. In the process, they raised crucial, enduring questions about the nature of economic-justice organizing. Full article

This essay uses the concept of Christian nationalism to explore the religious dynamics of the Contra war and U.S.–Nicaraguan relations during Ronald Reagan’s presidency. Religious organizations and individuals played crucial roles on both sides in the war in Nicaragua and in the debates in the United States over support for the Contras. Evangelistic work strengthened transnational ties between Christians, but also raised the stakes of the war; supporters of the Sandinistas and Contras alike alleged a victory by their adversary imperiled the future of Christianity in Nicaragua. Christian nationalism thus manifested itself and intertwined in both the United States and Nicaragua. Examining how evangelicals and Catholics in the United States and Nicaragua, as well as the Reagan administration, the Contras, and the Sandinistas, used Christian nationalism to build support for their policy objectives sheds light on both the malleability and the power of identifying faith with the state. Having assessed Christian nationalism as a tool and a locus of conflict in the Contra war, the essay then steps back and considers the larger methodological implications of using Christian nationalism as a category of analysis in U.S. foreign relations history. Full article

Between 1945 and 1980, evangelicals emerged as a key political constituency in American politics, helping to form the Religious Right and work for the election of Ronald Reagan and other conservative Republicans. This article argues that they embraced a distinctive type of revivalist nationalism, centered around the mass revival. Case studies of Billy Graham, Bill Bright, Jerry Falwell, and Ronald Reagan offer a narrative of postwar revivalist nationalism and demonstrate that evangelicals renegotiated the relationship between personal salvation and national renewal during this period, facilitating their mass entry into partisan politics. Billy Graham presented in his early crusades an unsophisticated assumption that mass conversion would lead to national renewal. Later revivalists such as Bill Bright, founder of Campus Crusade for Christ, sought to reorient revivalism toward directed political organization, leading in the 1970s to decreasing emphasis on personal conversion and increasing focus on the political process. By the 1980 presidential election, the Religious Right had completely abandoned the priority of personal conversion and sought instead to revive the “principles” of a Christian America. Ronald Reagan embodied this principle-oriented revival, and helped crystalize a revivalist nationalism that remains embedded in contemporary evangelical politics. Full article