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Keywords = Pinellia pedatisecta Schott

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11 pages, 2680 KiB  
Article
Alkaloids with Their Protective Effects Against Aβ25-35-Induced PC-12 Cell Injury from the Tubers of Pinellia pedatisecta Schott
by Xu Chen, Yangang Cao, Kaili Ye, Yanling Liu, Fangge Chi, Ying Niu, Di Lu, Bingxian Zhao, Lan Chen, Xiaoke Zheng and Weisheng Feng
Molecules 2024, 29(21), 5059; https://doi.org/10.3390/molecules29215059 - 26 Oct 2024
Cited by 1 | Viewed by 995
Abstract
Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] and one new natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined [...] Read more.
Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] and one new natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)-3, 6, and 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP). Full article
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29 pages, 1817 KiB  
Review
Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review
by Seung-Hyeok Park, Minsun Kim, Somi Lee, Woojin Jung and Bonglee Kim
Nutrients 2021, 13(1), 154; https://doi.org/10.3390/nu13010154 - 5 Jan 2021
Cited by 60 | Viewed by 8914
Abstract
Cervical cancer is the fourth most common cancer among women worldwide. Though several natural products have been reported regarding their efficacies against cervical cancer, there has been no review article that categorized them according to their anti-cancer mechanisms. In this study, anti-cancerous natural [...] Read more.
Cervical cancer is the fourth most common cancer among women worldwide. Though several natural products have been reported regarding their efficacies against cervical cancer, there has been no review article that categorized them according to their anti-cancer mechanisms. In this study, anti-cancerous natural products against cervical cancer were collected using Pubmed (including Medline) and google scholar, published within three years. Their mechanisms were categorized as induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, reduction of resistance, and regulation of miRNAs. A total of 64 natural products suppressed cervical cancer. Among them, Penicillium sclerotiorum extracts from Cassia fistula L., ethanol extracts from Bauhinia variegate candida, thymoquinone obtained from Nigella sativa, lipid-soluble extracts of Pinellia pedatisecta Schott., and 1′S-1′-acetoxychavicol extracted from Alpinia conchigera have been shown to have multi-effects against cervical cancer. In conclusion, natural products could be attractive candidates for novel anti-cancer drugs. Full article
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