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Keywords = Jingzaojing

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Article
Supplementation with Vitis vinifera Jingzaojing Leaf and Shoot Extract Improves Exercise Endurance in Mice
by Yong Gyun Lee, Hayoung Woo, Chul Choi, Ga-Hee Ryoo, Yun-Jo Chung, Ju-Hyung Lee, Su-Jin Jung, Soo-Wan Chae, Eun Ju Bae and Byung-Hyun Park
Nutrients 2022, 14(19), 4033; https://doi.org/10.3390/nu14194033 - 28 Sep 2022
Cited by 4 | Viewed by 2789
Abstract
Switching myofibers from the fast-glycolytic type to the slow-oxidative type is associated with an alleviation of the symptoms associated with various cardiometabolic diseases. This study investigates the effect of Vitis vinifera Jingzaojing leaf and shoot extract (JLSE), which is rich in phenolic compounds, [...] Read more.
Switching myofibers from the fast-glycolytic type to the slow-oxidative type is associated with an alleviation of the symptoms associated with various cardiometabolic diseases. This study investigates the effect of Vitis vinifera Jingzaojing leaf and shoot extract (JLSE), which is rich in phenolic compounds, on the regulation of skeletal muscle fiber-type switching, as well as the associated underlying mechanism. Male C57BL/6N mice were supplemented orally with vehicle or JLSE (300 mg/kg) and subjected to treadmill exercise training. After four weeks, mice in the JLSE-supplemented group showed significantly improved exercise endurance and mitochondrial oxidative capacity. JLSE supplementation increased the expression of sirtuin 6 and decreased Sox6 expression, thereby elevating the number of mitochondria and encouraging fast-to-slow myofiber switching. The results of our experiments suggest that JLSE supplementation reprograms myofiber composition to favor the slow oxidative type, ultimately enhancing exercise endurance. Full article
(This article belongs to the Section Sports Nutrition)
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