Search Results (6)

Peripheral T-cell lymphomas (PTCLs) are a rare and heterogenous subset of non-Hodgkin lymphoma characterized by an aggressive clinical course. Historically, the treatment of PTCLs have been analogous to that of aggressive B-cell lymphomas; however, it has been well-established that overall responses and complete remission rates are far inferior using near-identical chemotherapy strategies. Recently, there has been a plethora of newer agents designed to target distinguishing cellular and molecular features of specific PTCL subtypes. These agents have been proven to yield superior anti-lymphoma responses and, in some cases, overall survival in the relapsed, refractory, and frontline treatment setting. In this review, we will summarize and highlight the most influential clinical trials leading to the Food and Drug Administration (FDA) approval of several novel therapeutic agents against PTCL, with an emphasis on emerging studies and strategies to expand their potential use in the frontline treatment setting. Full article

Antimicrobial peptides and proteins (AMPs) provide an important line of defence against invading microorganisms. However, the activity of AMPs against the human fungal pathogen Aspergillus fumigatus remains poorly understood. Therefore, the aim of this study was to characterise the anti-Aspergillus activity of specific human AMPs, and to determine whether A. fumigatus can possess resistance to specific AMPs, as a result of in-host adaptation. AMPs were tested against a wide range of clinical isolates of various origins (including cystic fibrosis patients, as well as patients with chronic and acute aspergillosis). We also tested a series of isogenic A. fumigatus isolates obtained from a single patient over a period of 2 years. A range of environmental isolates, obtained from soil in Scotland, was also included. Firstly, the activity of specific peptides was assessed against hyphae using a measure of fungal metabolic activity. Secondly, the activity of specific peptides was assessed against germinating conidia, using imaging flow cytometry as a measure of hyphal growth. We showed that lysozyme and histones inhibited hyphal metabolic activity in all the A. fumigatus isolates tested in a dose-dependent fashion. In addition, imaging flow cytometry revealed that histones, β-defensin-1 and lactoferrin inhibited the germination of A. fumigatus conidia. Full article

The writings of J.G. Ballard respond to the sciences in multiple ways; as such his (early) writing may productively be discussed as science fiction. However, the theoretical discipline to which he publicly signalled most allegiance, psychoanalysis, is one whose status in relation to science is highly contested and complex. In the 1960s Ballard signalled publicly in his non-fiction writing a belief in psychoanalysis as a science, a position in keeping with psychoanalysis’ contemporary status as the predominant psychological paradigm. Various early Ballard stories enact psychoanalytic theories, while the novel usually read as his serious debut, The Drowned World, aligns itself allusively with an oft-cited depiction by Freud of the revelatory and paradigm-changing nature of the psychoanalytic project. Ballard’s enthusiastic embrace of psychoanalysis in his early 1960s fiction mutated into a fascinatingly delirious vision in some of his most experimental work of the late 1960s and early 1970s of a fusion of psychoanalysis with the mathematical sciences. This paper explores how this ‘Marriage of Freud and Euclid’ is played out in its most systematic form in The Atrocity Exhibition and its successor Crash. By his late career Ballard was acknowledging problems raised over psychoanalysis’ scientific status in the positivist critique of Karl Popper and the work of various combatants in the ‘Freud Wars’ of the 1990s; Ballard at this stage seemed to move towards agreement with interpretations of Freud as a literary or philosophical figure. However, despite making pronouncements reflecting changes in dominant cultural appraisals of Freud, Ballard continued in his later writings to extrapolate the fictive and interpretative possibilities of Freudian and post-Freudian ideas. This article attempts to develop a deeper understanding of Ballard’s ‘scientific’ deployment of psychoanalysis in The Atrocity Exhibition and Crash within the context of a more fully culturally-situated understanding of psychoanalysis’ relationship to science, and thereby to create new possibilities for understanding the meanings of Ballard’s writing within culture at large. Full article

This paper offers a discussion of J. G. Ballard’s first four novels, The Wind From Nowhere (1962), The Drowned World (1962), The Drought (1965), and The Crystal World (1966) that centers on their portrayal of environmental transformation. Drawing on revised conceptualizations of the second law of thermodynamics and recent materialist scholarship, I illustrate how Ballard invokes material transformations that are ambivalently coded as terminal stasis and morphogenesis. In anticipations of the paradigm of the Anthropocene and ecocritical approaches to global climate change, Ballard’s novels re-embed the human in an ecology of inhuman forces and modes of self-organization that radically challenge entrenched ontological divisions and systemic boundaries. Particular attention is paid to the ways in which emergent structures, such as hurricanes and crystals identify his landscapes as dissipative systems far from equilibrium and rife with potential for the spontaneous generation of form. This resonance with scientific frameworks reveals itself in poetic registers that parallelize metaphors of life and death, and hinge on an estrangement of not only landscape, but also temporality, thus literalizing what it might mean to understand the human as a geological subject in the age of the Anthropocene. Full article

“We’re all going to be starring in our own sit-coms, and they’ll be very strange sit-coms too, like the inside of our heads.”—J. G. Ballard, Extreme Metaphors. Ballard’s prediction about the possibility of projecting the inside of our own heads is highly illuminating in light of contemporary discourses on participatory media culture and online video-sharing platforms. This is not least due to the documented instances of violence and sexual deviance surrounding prominent figures on YouTube that lend a considerable amount of credence to what Ballard described, in his 1977 short story ‘The Intensive Care Unit’, as a ‘liberating affectlessness [that] allowed those who wished to explore the fullest range of sexual possibility and paved the way for the day when a truly guilt-free sexual perversity and, even, psychopathology might be enjoyed by all.’ This article examines how Ballard’s preoccupation with this ‘liberating affectlessness’—or as he notably termed it in his introduction to Crash, ‘the death of affect’—compares to the impetus that psychologists such as Jonathan Rottenberg and Sheri L. Johnson place upon an ‘affective science’ approach to exploring and treating psychopathology—an approach that they affirm has ‘tremendous potential to facilitate scientific work on the role of emotions in psychopathology.’ This active interplay between emotion and affect (or the calculated lack of) on one hand, and psychopathology on the other that Ballard and Rottenberg and Johnson investigate from different angles also feeds into discourses on online participatory media and the ways that users engage with online media. Specifically, this section of the article will draw upon the roles of private and public spaces, and the breakdown of traditional barriers between them, as well as the commercial factors that define and underpin this new media culture. ‘The Intensive Care Unit’ and later novels such as Cocaine Nights (1996) play upon these themes as a means of anticipating and demonstrating how, in Ballard’s fiction as well as in real-life instances, psychopathology emerges in the breakdown of the barriers between lives lived excessively on screen and the external, sensory and emotional world. Full article

This paper examines the leading role played by the American mechanical performance group Survival Research Laboratories (SRL) within the field of machine art during the late 1970s and early 1980s, and as organized under the headings of (a) destruction/survival; (b) the cyborg as a symbol of human/machine interpenetration; and (c) biomechanical sexuality. As a manifestation of the era’s “industrial” culture, moreover, the work of SRL artists Mark Pauline and Eric Werner was often conceived in collaboration with industrial musicians like Monte Cazazza and Graeme Revell, and all of whom shared a common interest in the same influences. One such influence was the novel Crash by English author J. G. Ballard, and which in turn revealed the ultimate direction in which all of these artists sensed society to be heading: towards a world in which sex itself has fallen under the mechanical demiurge. Full article