Search Results (8)

Philosophers and literary scholars have notoriously struggled with the periodization of Hölderlin’s work, showing particular reluctance to situate it within Early Romanticism. But there can be no doubt that Hölderlin’s philosophical work resides within the context of an anti-foundationalist criticism, which students of Karl Leonhard Reinhold leveled at his programmatic deduction from a “highest principle” (oberster Grundsatz) in the early 1790s and intensified following Fichte’s lectures (1794/95) on the Science of Knowledge (Wissenschaftslehre). Novalis belonged directly to the circle of Reinhold students, while Hölderlin gained access to it through Friedrich Immanuel Niethammer, his friend from student days in Tübingen and “mentor” in Jena. Niethammer encouraged both Hölderlin and Novalis to contribute to his Philosophisches Journal, conceived as a forum for discussing the pros and cons of foundational philosophy (Grundsatzphilosophie). Novalis’ Fichte-Studies and Hölderlin’s philosophical fragments from 1795/96 can be read as drafts for such an essay. Both men developed similar critiques of Reinhold’s reformulated, subject-centered “highest principle”, the “principle of consciousness” (Satz des Bewusstseins). They argued that according to Reinhold, self-consciousness is a representation, i.e., a binary relationship that provides no explanation for the certainty of unity associated with self-consciousness. Both postulate a transcendent “ground of unity”, which would address this issue while remaining inaccessible to consciousness. My article demonstrates that both men failed to disentangle themselves from the snares of Reinhold’s model of representation, and both transferred the solution for the problem of self-consciousness onto the extra-philosophical medium of art. Full article

The birth of modern aesthetics cannot be separated from the emergence of a new, non-dogmatic conception of religion and theology. Friedrich Schlegel advocated ‘art as new religion’ while Friedrich Schleiermacher developed a vision on religion as a deeply aesthetic experience. In this rich intellectual context, one author stands out as deeply steeped in this field of innovative dialogues between philosophy, religion and art (against the backdrop of profound historical transformations) and as a singular figure beckoning towards a future (and a future language) that was still to come: Friedrich Hölderlin. In his later work, Hölderlin’s poetic voice retreats into a process of meticulous reading and writing, a complex score of traces and signs that articulate difference, not-yet-presence and potentiality, which is nothing other than the experience of finite time. In doing so, Hölderlin retraces the divine in history and in human existence: its retreat and expected arrival. In this article, we present readings and interpretations of Hölderlin’s later poetry, with a specific focus on the Winke or hints of the gods, and the vocabulary of nods and signs (Zeichen) signifying the experience of time’s passing as the announcement of an unthinkable future. By involving Jean-Luc Nancy’s rethinking of the Winke as intersections of the divinity of humanity and the humanity of divinity, we will arrive at a new understanding of Hölderlin’s emblematic figures of modernity: the stranger and the passer-by as receivers and transmitters of these Winke. Full article

Perianal fistulizing Crohn’s Disease (CD) with abscess formation represents an aggressive phenotype in Inflammatory Bowel Disease (IBD) with increased morbidity. Treatment is multidisciplinary and includes antibiotics, but knowledge about the microbial spectrum is rare often resulting in inadequate antimicrobial therapy. In this single center retrospective study, all patients who were operated due to perianal abscess formation were retrospectively analyzed and the microbial spectrum evaluated. Patients were divided into a CD and non-CD group with further subgroup analysis. 138 patients were finally included in the analysis with 62 patients suffering from CD. Relevant differences were detected for the microbial spectrum with anaerobic bacteria being significantly more often isolated from non-CD patients. In a subgroup-analysis of CD patients only, medical therapy had a relevant effect on the microbial spectrum since Streptococcus groups and Enterobacterales were significantly more often isolated in patients treated with steroids compared to those being treated by antibodies. In conclusion, the microbial spectrum of patients suffering from CD varies significantly from non-CD patients and immunosuppressive medication has a relevant effect on isolated pathogens. Based on that, adaption of antibiotic treatment might be discussed in the future. Full article

Intraabdominal abscess formation occurs in up to 30% of patients suffering from Crohn´s disease (CD). While international guidelines recommend a step-up approach with a combination of empiric antibiotic therapy and percutaneous drainage to delay or even avoid surgery, evidence about microbial spectrum in penetrating ileitis is sparse. We retrospectively assessed outcomes of 46 patients with terminal penetrating Ileitis where microbial diagnostics have been performed and compared microbial spectrum and antibiotic resistance profile of CD patients with patients suffering from diverticulitis with intraabdominal abscess formation. In both groups, the most frequently isolated pathogen was the gram-negative bacterium E. coli belonging to the family of Enterobacterales. However, overall Enterobacterales were significantly more often verifiable in the control group than in CD patients. Furthermore, microbial analysis showed significant differences regarding isolation of anaerobic pathogens with decreased frequency in patients with CD. Subgroup analysis of CD patients to evaluate a potential influence of immunosuppressive therapy on microbial spectrum only revealed that Enterobacterales was less frequently detected in patients treated with steroids. Immunosuppressive therapy did not show any impact on all other groups of pathogens and did not change antibiotic resistance profile of CD patients. In conclusion, we were able to demonstrate that the microbial spectrum of CD patients does differ only for some pathogen species without increased rate of antibiotic resistance. However, the empiric antibiotic therapy for CD-associated intra-abdominal abscess remains challenging since different points such as local epidemiological and microbiological data, individual patient risk factors, severity of infection, and therapy algorithm including non-surgical and surgical therapy options should be considered before therapeutical decisions are made. Full article

The planning and implementation of public transport involves many data sources. These data sources in turn generate a high volume of data, in a wide variety of formats and data rates. This phenomenon is reinforced by the ongoing digitization of public transport; new data sources have continuously emerged in public transport in recent years and decades. This results in a great potential for the application and utilization of data science methods in public transport. Using big data methods and sources can, or in some cases already does, contribute to a better understanding and the further optimization of public transport networks, public transport service and public transport in general. This paper classifies data sources in the field of public transport and examines systematically for which use cases the data are used or can be used. These steps contribute by structuring ongoing discussions about the application of data science in the public transport domain and illustrate the potential of the application of data science for public transport. We present several use cases in which we applied data science methods, such as machine learning and visualization to public transport data. Several of these projects use data from automated passenger information systems, a data source that has not been widely studied to date. We report our findings for these use cases and discuss the lessons learned, to inform future research on these use cases and discuss their potential. This paper concludes with a summary of the typical problems that occur when dealing with big public transport data and a discussion of solutions for these problems. This discussion identifies future work and topics worth investigating for public transport companies as well as for researchers. Working on these topics will, in our opinion, support the improvement of public transport towards the efficiency and attractiveness that is needed for public transport to play its essential role in future sustainable mobility. The application of these methods in public transport requires the collaboration of domain experts with researchers and data scientists, calling for a mutual understanding. This paper also contributes to this understanding by providing an overview of the methods that are already used, potential new use cases, data sources, challenges and possible solutions. Full article

Despite the increasing incidence and prevalence of Crohn’s Disease (CD), no curative options exist and treatment remains complex. While therapy has mainly focused on medical approaches in the past, growing evidence reveals that in cases of limited inflammation, surgery can suffice as an alternative primary treatment. We retrospectively assessed the disease course and outcomes of 103 patients with terminal Ileitis who underwent primary surgery (n = 29) or received primary medical treatment followed by surgery (n = 74). Primary endpoint was the need for immunosuppressive medication after surgical treatment (ileocecal resection, ICR) during a two-years follow-up. Rates for laparoscopic ICR were enhanced in case of early surgery, but no differences were seen for postoperative complications. In case of immunosuppressive medication, patients with ICR at an early state of disease needed significantly less anti-inflammatory medication during the two-year postoperative follow-up compared to patients who were primarily treated medically. Furthermore, in a subgroup analysis for patients with localized ileocecal disease manifestation, early surgery consistently resulted in a decreased amount of medical therapy postoperatively. In conclusion primary ICR is safe and effective in patients with limited CD, and the need for immunosuppressive medication during the postoperative follow-up is low compared to patients receiving surgery at a later stage of disease. Full article

The oncogenic Epstein-Barr virus (EBV) expresses 44 mature microRNAs and two non-coding EBER RNAs of 167 (EBER1) and 172 (EBER2) nt length. MiRNA profiling of NK/T cell lines and primary cells and Northern blotting of EBV-infected cell lines and primary tumors revealed processing of EBER1 to short 5′-derived RNAs of approximately 23, 52 and 70 nt (EBER123, EBER152, and EBER170) and of EBER2 to 3′ fragments. The biogenesis of these species is independent of Dicer, and EBER123 does not act like a miRNA OPEN ACCESS Non-Coding RNA 2015, 1 171 to target its complementary sequence. EBER1, EBER2 and EBER123 were bound by the lupus antigen (La), a nuclear and cytoplasmic protein that facilitates RNAi. Consistent with this, the EBERs affect regulation of interleukin 1alpha (IL1α) and RAC1 reporters harboring miR target sequences, targets of miR-142-3p. However, the EBERs have no effect upon another target of miR-142-3p, ADCY9, nor on TOMM22, a target of ebv-miR-BART16, indicative of selective modulation of gene expression by the EBERs. Full article

This is a short (fragmentary) history of fragmentary writing from the German Romantics (F. W. Schlegel, Friedrich Hölderlin) to modern and contemporary concrete or visual poetry. Such writing is (often deliberately) a critique of the logic of subsumption that tries to assimilate whatever is singular and irreducible into totalities of various categorical or systematic sorts. Arguably, the fragment (parataxis) is the distinctive feature of literary Modernism, which is a rejection, not of what precedes it, but of what Max Weber called “the rationalization of the world” (or Modernity) whose aim is to keep everything, including all that is written, under surveillance and control. Full article