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Keywords = Echinomuricea

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20 pages, 526 KiB  
Review
Natural Product Chemistry of Gorgonian Corals of the Family Plexauridae Distributed in the Indo-Pacific Ocean
by Li-Hsueh Wang, Jyh-Horng Sheu, Shih-Yao Kao, Jui-Hsin Su, Yung-Husan Chen, Yu-Hsin Chen, Yin-Di Su, Yu-Chia Chang, Lee-Shing Fang, Wei-Hsien Wang, Yang-Chang Wu and Ping-Jyun Sung
Mar. Drugs 2012, 10(11), 2415-2434; https://doi.org/10.3390/md10112415 - 1 Nov 2012
Cited by 10 | Viewed by 6840
Abstract
The structures, names, bioactivities and references of 105 natural products obtained from gorgonian corals belonging to the family Plexauridae with an Indo-Pacific distribution are described in this review. All compounds mentioned in this review were obtained from gorgonian corals belonging to the genera [...] Read more.
The structures, names, bioactivities and references of 105 natural products obtained from gorgonian corals belonging to the family Plexauridae with an Indo-Pacific distribution are described in this review. All compounds mentioned in this review were obtained from gorgonian corals belonging to the genera Astrogorgia, Bebryce, Echinomuricea, Euplexaura and Menella. Full article
8 pages, 395 KiB  
Article
Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae)
by Hsu-Ming Chung, Li-Chung Hu, Wei-Hsuan Yen, Jui-Hsin Su, Mei-Chin Lu, Tsong-Long Hwang, Wei-Hsien Wang and Ping-Jyun Sung
Mar. Drugs 2012, 10(10), 2246-2253; https://doi.org/10.3390/md10102246 - 17 Oct 2012
Cited by 19 | Viewed by 6759
Abstract
A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory [...] Read more.
A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria. Full article
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8 pages, 229 KiB  
Article
Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.
by Ching-Hsiao Cheng, Hsu-Ming Chung, Tsong-Long Hwang, Mei-Chin Lu, Zhi-Hong Wen, Yueh-Hsiung Kuo, Wei-Hsien Wang and Ping-Jyun Sung
Molecules 2012, 17(8), 9443-9450; https://doi.org/10.3390/molecules17089443 - 7 Aug 2012
Cited by 15 | Viewed by 6427
Abstract
A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging [...] Read more.
A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. Full article
(This article belongs to the Section Natural Products Chemistry)
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11 pages, 311 KiB  
Article
Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)
by Hsu-Ming Chung, Pei-Han Hong, Jui-Hsin Su, Tsong-Long Hwang, Mei-Chin Lu, Lee-Shing Fang, Yang-Chang Wu, Jan-Jung Li, Jih-Jung Chen, Wei-Hsien Wang and Ping-Jyun Sung
Mar. Drugs 2012, 10(5), 1169-1179; https://doi.org/10.3390/md10051169 - 23 May 2012
Cited by 19 | Viewed by 8387
Abstract
A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane [...] Read more.
A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. Full article
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