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Keywords = EMICORON

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6 pages, 942 KB  
Article
New Developments in the Synthesis of EMICORON
by Massimo Pitorri, Marco Franceschin, Ilaria Serafini, Alessandro Ciccòla, Claudio Frezza and Armandodoriano Bianco
High-Throughput 2018, 7(3), 22; https://doi.org/10.3390/ht7030022 - 29 Aug 2018
Cited by 1 | Viewed by 3408
Abstract
This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo [...] Read more.
This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo antitumor activities that interferes with the tumor growth and development using a multi-target mechanism of action. The provided modifications, which involved the reaction times, the reaction conditions, and the work-up procedures, allowed the global yield of the process to be increased from 28% to about 40%. Thus, this new procedure may be more suitable for recovering higher amounts of EMICORON to be used in further preclinical studies. Full article
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