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High-Throughput 2018, 7(3), 22; https://doi.org/10.3390/ht7030022

New Developments in the Synthesis of EMICORON

1
Dipartimento di Chimica: Università di Roma “La Sapienza”, Piazzale Aldo Moro 5, 00185 Rome, Italy
2
Dipartimento di Biologia Ambientale: Università di Roma “La Sapienza”, Piazzale Aldo Moro 5, 00185 Rome, Italy
*
Authors to whom correspondence should be addressed.
Received: 26 July 2018 / Revised: 14 August 2018 / Accepted: 21 August 2018 / Published: 29 August 2018
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Abstract

This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo antitumor activities that interferes with the tumor growth and development using a multi-target mechanism of action. The provided modifications, which involved the reaction times, the reaction conditions, and the work-up procedures, allowed the global yield of the process to be increased from 28% to about 40%. Thus, this new procedure may be more suitable for recovering higher amounts of EMICORON to be used in further preclinical studies. View Full-Text
Keywords: EMICORON; polycyclic aromatic compounds; organic synthesis; synthesis improvements; anticancer activity EMICORON; polycyclic aromatic compounds; organic synthesis; synthesis improvements; anticancer activity
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Pitorri, M.; Franceschin, M.; Serafini, I.; Ciccòla, A.; Frezza, C.; Bianco, A. New Developments in the Synthesis of EMICORON. High-Throughput 2018, 7, 22.

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