New Developments in the Synthesis of EMICORON
AbstractThis paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo antitumor activities that interferes with the tumor growth and development using a multi-target mechanism of action. The provided modifications, which involved the reaction times, the reaction conditions, and the work-up procedures, allowed the global yield of the process to be increased from 28% to about 40%. Thus, this new procedure may be more suitable for recovering higher amounts of EMICORON to be used in further preclinical studies. View Full-Text
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Pitorri, M.; Franceschin, M.; Serafini, I.; Ciccòla, A.; Frezza, C.; Bianco, A. New Developments in the Synthesis of EMICORON. High-Throughput 2018, 7, 22.
Pitorri M, Franceschin M, Serafini I, Ciccòla A, Frezza C, Bianco A. New Developments in the Synthesis of EMICORON. High-Throughput. 2018; 7(3):22.Chicago/Turabian Style
Pitorri, Massimo; Franceschin, Marco; Serafini, Ilaria; Ciccòla, Alessandro; Frezza, Claudio; Bianco, Armandodoriano. 2018. "New Developments in the Synthesis of EMICORON." High-Throughput 7, no. 3: 22.
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