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Keywords = DNA polymerase III holoenzyme

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28 pages, 1054 KiB  
Review
The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery
by Jon M. Kaguni
Antibiotics 2018, 7(1), 23; https://doi.org/10.3390/antibiotics7010023 - 14 Mar 2018
Cited by 17 | Viewed by 8239
Abstract
DNA replication is an essential process. Although the fundamental strategies to duplicate chromosomes are similar in all free-living organisms, the enzymes of the three domains of life that perform similar functions in DNA replication differ in amino acid sequence and their three-dimensional structures. [...] Read more.
DNA replication is an essential process. Although the fundamental strategies to duplicate chromosomes are similar in all free-living organisms, the enzymes of the three domains of life that perform similar functions in DNA replication differ in amino acid sequence and their three-dimensional structures. Moreover, the respective proteins generally utilize different enzymatic mechanisms. Hence, the replication proteins that are highly conserved among bacterial species are attractive targets to develop novel antibiotics as the compounds are unlikely to demonstrate off-target effects. For those proteins that differ among bacteria, compounds that are species-specific may be found. Escherichia coli has been developed as a model system to study DNA replication, serving as a benchmark for comparison. This review summarizes the functions of individual E. coli proteins, and the compounds that inhibit them. Full article
(This article belongs to the Special Issue Bacterial DNA Replication and Replication Inhibitors)
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