Search Results (5)

Tooth development (odontogenesis) is regulated by interactions between epithelial and mesenchymal tissues through signaling pathways such as Bone Morphogenetic Protein (BMP), Wingless-related integration site (Wnt), Sonic Hedgehog (SHH), and Fibroblast Growth Factor (FGF). Mesenchymal stem cells (MSCs) derived from dental tissues—including dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), and dental follicle progenitor cells (DFPCs)—show promise for regenerative dentistry due to their multilineage differentiation potential. Epigenetic regulation, particularly DNA methylation, is hypothesized to underpin their distinct regenerative capacities. This study reanalyzed publicly available DNA methylation data generated with Illumina Infinium HumanMethylation450 BeadChip arrays (450K arrays) from DPSCs, PDLSCs, and DFPCs. High-confidence CpG sites were selected based on detection p-values, probe variance, and genomic annotation. Principal Component Analysis (PCA) and hierarchical clustering identified distinct methylation profiles. Functional enrichment analyses highlighted biological processes and pathways associated with specific methylation clusters. Noncoding RNA analysis was integrated to construct regulatory networks linking DNA methylation patterns with key developmental genes. Distinct epigenetic signatures were identified for DPSCs, PDLSCs, and DFPCs, characterized by differential methylation across specific genomic contexts. Functional enrichment revealed pathways involved in odontogenesis, osteogenesis, and neurodevelopment. Network analysis identified central regulatory nodes—including genes, such as PAX6, FOXC2, NR2F2, SALL1, BMP7, and JAG1—highlighting their roles in tooth development. Several noncoding RNAs were also identified, sharing promoter methylation patterns with developmental genes and being implicated in regulatory networks associated with stem cell differentiation and tissue-specific function. Altogether, DNA methylation profiling revealed that distinct epigenetic landscapes underlie the developmental identity and differentiation potential of dental-derived mesenchymal stem cells. This integrative analysis highlights the relevance of noncoding RNAs and regulatory networks, suggesting novel biomarkers and potential therapeutic targets in regenerative dentistry and orthodontics. Full article

UAV small target detection in urban security, disaster monitoring, agricultural inspection, and other fields faces the challenge of increasing accuracy and real-time requirements. However, existing detection algorithms still have weak small target representation ability, extensive computational resource overhead, and poor deployment adaptability. Therefore, this paper proposes a lightweight algorithm, I-YOLOv11n, based on YOLOv11n, which is systematically improved in terms of both feature enhancement and structure compression. The RFCBAMConv module that combines deformable convolution and channel–spatial attention is designed to adjust the receptive field and strengthen the edge features dynamically. The multiscale pyramid of STCMSP context and the lightweight Transformer–DyHead hybrid detection head are designed by combining the multiscale hole feature pyramid (DFPC), which realizes the cross-scale semantic modeling and adaptive focusing of the target area. A collaborative lightweight strategy is proposed. Firstly, the semantic discrimination ability of the teacher model for small targets is transferred to guide and protect the subsequent compression process by integrating the mixed knowledge distillation of response alignment, feature imitation, and structure maintenance. Secondly, the LAMP–Taylor channel pruning mechanism is used to compress the model redundancy, mainly to protect the key channels sensitive to shallow small targets. Finally, K-means++ anchor frame optimization based on IoU distance is implemented to adapt the feature structure retained after pruning and the scale distribution of small targets of UAV. While significantly reducing the model size (parameter 3.87 M, calculation 14.7 GFLOPs), the detection accuracy of small targets is effectively maintained and improved. Experiments on VisDrone, AI-TOD, and SODA-A datasets show that the mAP@0.5 and mAP@0.5:0.95 of I-YOLOv11n are 7.1% and 4.9% higher than the benchmark model YOLOv11 n, respectively, while maintaining real-time processing capabilities, verifying its comprehensive advantages in accuracy, light weight, and deployment. Full article

Soil moisture (SM), as one of the crucial environmental factors, has traditionally been estimated using global navigation satellite system interferometric reflectometry (GNSS-IR) microwave remote sensing technology. This approach relies on the signal-to-noise ratio (SNR) reflection component, and its accuracy hinges on the successful separation of the reflection component from the direct component. In contrast, the presence of carrier phase and pseudorange multipath errors enables soil moisture retrieval without the requirement for separating the direct component of the signal. To acquire high-quality combined multipath errors and diversify GNSS-IR data sources, this study establishes the dual-frequency pseudorange combination (DFPC) and dual-frequency carrier phase combination (L4) that exclude geometrical factors, ionospheric delay, and tropospheric delay. Simultaneously, we propose two methods for estimating soil moisture: the DFPC method and the L4 method. Initially, the equal-weight least squares method is employed to calculate the initial delay phase. Subsequently, anomalous delay phases are detected and corrected through a combination of the minimum covariance determinant robust estimation (MCD) and the moving average filter (MAF). Finally, we utilize the multivariate linear regression (MLR) and extreme learning machine (ELM) to construct multi-satellite linear regression models (MSLRs) and multi-satellite nonlinear regression models (MSNRs) for soil moisture prediction, and compare the accuracy of each model. To validate the feasibility of these methods, data from site P031 of the Plate Boundary Observatory (PBO) H₂O project are utilized. Experimental results demonstrate that combining MCD and MAF can effectively detect and correct outliers, yielding single-satellite delay phase sequences with a high quality. This improvement contributes to varying degrees of enhanced correlation between the single-satellite delay phase and soil moisture. When fusing the corrected delay phases from multiple satellite orbits using the DFPC method for soil moisture estimation, the correlations between the true soil moisture values and the predicted values obtained through MLR and ELM reach 0.81 and 0.88, respectively, while the correlations of the L4 method can reach 0.84 and 0.90, respectively. These findings indicate a substantial achievement in high-precision soil moisture estimation within a small satellite-elevation angle range. Full article

The integration of hybrid renewable energy sources (HRESs) into the grid is currently being encouraged to meet the increasing demand for electric power and reduce fossil fuels which are causing environmental-related problems. Integration of HRESs into the grid can create some power quality (PQ) problems. To mitigate PQ problems and improve the performance of grid-connected HRESs some flexible devices should be used. This paper presents a distributed power flow controller (DPFC), as a type of flexible device to mitigate some PQ problems, including voltage sag, swell, disruptions, and eliminating the harmonics in a hybrid power system (HPS). The HPS presented in this work comprises a photo voltaic (PV) system, wind turbine (WT) and battery energy storage system (BESS). As a result, black widow optimization (BWO) with DPFC with real and reactive power (DPFC-PQ) is built in this paper to solve the PQ issues in HRES systems. The main aim of the work is to mitigate PQ problems and compensate for load demand in the HRES scheme. The controller used to drive this DPFC-PQ is a fractional-order PID (FOPID) controller optimized by the black widow optimization (BWO) technique. To assess the capability of BWO in fine-tuning the FOPID controller parameters, twelve optimization techniques were presented: P&O, PSO, Cuckoo, GA, GSA, BBO, Whale, ESA, RFA, ASO, and EVORFA. Additionally, a comparison between the FOPID controller and the classical PI controller is introduced. The results showed that the proposed BWO-FOPID controller for DFPC had mitigated the PQ problems in grid-connected HRESs. The system’s performance with the presented BWO-FOPID controller is compared with eleven optimization techniques used to optimize the FOPID controller and also compared with the conventional PI controller. The design of the proposed system is implemented in the MATLAB/Simulink platform and performances were analyzed. Full article

Dental follicle progenitor/stem cells (DFPCs) are a group of dental mesenchyme stem cells that lie in the dental follicle and play a critical role in tooth development and maintaining function. Originating from neural crest, DFPCs harbor a multipotential differentiation capacity. More importantly, they have superiorities, including the easy accessibility and abundant sources, active self-renewal ability and noncontroversial sources compared with other stem cells, making them an attractive candidate in the field of tissue engineering. Recent advances highlight the excellent properties of DFPCs in regeneration of orofacial tissues, including alveolar bone repair, periodontium regeneration and bio-root complex formation. Furthermore, they play a unique role in maintaining a favorable microenvironment for stem cells, immunomodulation and nervous related tissue regeneration. This review is intended to summarize the current knowledge of DFPCs, including their stem cell properties, physiological functions and clinical application potential. A deep understanding of DFPCs can thus inspire novel perspectives in regenerative medicine in the future. Full article