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Keywords = Cyclamen europaeum

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12 pages, 2311 KiB  
Article
Ex-Vivo and In-Vivo Assessment of Cyclamen europaeum Extract After Nasal Administration
by Francisco Fernández-Campos, Beatriz Clares, María J Rodríguez-Lagunas, Olga Jauregui, Isidre Casals and Ana C Calpena
Pharmaceutics 2019, 11(9), 426; https://doi.org/10.3390/pharmaceutics11090426 - 21 Aug 2019
Cited by 8 | Viewed by 4231
Abstract
Rhinosinusitis is a prevalent disorder with a severe impact on the health-related quality of life. Saponins of Cyclamen europaeum exert a clinically proven curative effect on rhinosinusitis symptoms when instilled into the nasal cavity, however, more extensive preclinical assessment is required to better [...] Read more.
Rhinosinusitis is a prevalent disorder with a severe impact on the health-related quality of life. Saponins of Cyclamen europaeum exert a clinically proven curative effect on rhinosinusitis symptoms when instilled into the nasal cavity, however, more extensive preclinical assessment is required to better characterize the efficacy of this botanical extract. This work evaluates the potential use of a natural freeze-dried extract of C. europaeum given as topical nasal administration. Permeation experiment on porcine nasal mucosa was performed with Franz diffusion cells. Experiments in rabbits were performed to test for any toxicological, hematological, biochemical or histological evidence of systemic action. No theoretical levels of saponins were found in the receptor chamber of Franz diffusion cells. Hematological data did not show significant differences between control and experimental animals (p > 0.05). Histological studies also showed that enhanced secretory activity in response to intranasal administration was not accompanied by any visible signs of injury. An examination of the brain, lungs, liver, kidneys, spleen, and gastrointestinal organs did not reveal any abnormality. The absence of mucosal permeation of saponins and negligible probability of C. europaeum saponins absorption in the course of a therapeutic application was demonstrated. Full article
(This article belongs to the Special Issue Intranasal Drug Delivery Systems)
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