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Keywords = Croton oligandrus

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9 pages, 444 KB  
Article
Ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex Hutch. and Assessment of Their Cytotoxicity against Human Cancer Cell Lines
by Stephanie Tamdem Guetchueng, Lutfun Nahar, Kenneth James Ritchie, Fyaz Mahmood Daud Ismail, Andrew Robert Evans and Satyajit Dey Sarker
Molecules 2018, 23(2), 410; https://doi.org/10.3390/molecules23020410 - 13 Feb 2018
Cited by 23 | Viewed by 4439
Abstract
New clerodane diterpenes, 12-epi-megalocarpodolide D (2) and an epimeric mixture of crotonolins A (3) and B (4), were isolated from the bark of Croton oligandrus following a bioassay-guided isolation protocol. Known compounds, megalocarpodolide D ( [...] Read more.
New clerodane diterpenes, 12-epi-megalocarpodolide D (2) and an epimeric mixture of crotonolins A (3) and B (4), were isolated from the bark of Croton oligandrus following a bioassay-guided isolation protocol. Known compounds, megalocarpodolide D (1), 12-epi-crotocorylifuran (5), cluytyl-ferulate (6), hexacosanoyl- ferulate (7), vanillin (8), acetyl-aleuritolic acid (9) and lupeol (10), were also isolated. The structures of the isolated compounds (110) were elucidated by spectroscopic means. The cytotoxicity of compounds 110 was assessed against A549, MCF7, PC3 and PNT2 cell lines using the MTT assay. Compounds 1 and 2 showed moderate levels of activity against both A549 and MCF7 cells with 1 being the most active with IC50 values of 63.8 ± 13.8 and 136.2 ± 22.7 µM against A549 and MCF7 cells, respectively. The epimeric mixture of 3 and 4 was moderately active against A549 and PC3 cells (IC50 = 128.6 ± 31.0 and 111.2 ± 2.9 µM, respectively). Full article
(This article belongs to the Section Natural Products Chemistry)
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