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Keywords = Baccharis trimera

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17 pages, 2284 KiB  
Article
Herbicidal Activity of Baccharis trimera Extract on Oryza sativa L. and Cyperus ferax
by Aline Mazoy Lopes, Lucas Kila Ribeiro, Maurício Ricardo de Melo Cogo, Lucas Mironuk Frescura, Marcelo Barcellos da Rosa, Alex Schulz, Ederson Rossi Abaide, Marcus Vinícius Tres and Giovani Leone Zabot
Agriculture 2025, 15(13), 1431; https://doi.org/10.3390/agriculture15131431 - 3 Jul 2025
Viewed by 334
Abstract
This study evaluated the application of the aqueous extract from Baccharis trimera (Less) DC. in the control of weed species Oryza sativa L. and Cyperus ferax Rich. during the germination and early development stages. Extracts were obtained through pressurized liquid extraction using kinetic [...] Read more.
This study evaluated the application of the aqueous extract from Baccharis trimera (Less) DC. in the control of weed species Oryza sativa L. and Cyperus ferax Rich. during the germination and early development stages. Extracts were obtained through pressurized liquid extraction using kinetic assays. Shorter extraction times (1 to 10 min) showed extracts with higher inhibitory effects on seed germination, shoot and root lengths, and fresh and dry mass of the plants. The survival of treated plants was also affected, especially during the early stages of development, reaching up to 40% of mortality. HPLC analysis identified phenolic compounds such as ferulic acid, rutin, quercitrin, and quercetin, with higher concentrations found in the extracts obtained at shorter times of extraction. The reduction in these compounds over longer extraction times was correlated with decreased inhibitory activity. The results indicate that the aqueous extract of B. trimera (Less) DC. holds potential for ecological weed management, standing out as a viable alternative to reduce weed resistance to synthetic herbicides. Full article
(This article belongs to the Special Issue Preparation, Function and Application of Agrochemicals)
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16 pages, 10343 KiB  
Article
Authentication and Quality Control of the Brazilian Traditional Herb ‘Carquejas’ (Baccharis Species) Using Morpho-Anatomy and Microscopy
by Kevin Alves Antunes, Vijayasankar Raman, Wilmer Hervet Perera, Gustavo Heiden, Roberto Pontarolo, Paulo Vitor Farago, Ikhlas Ahmed Khan and Jane Manfron
Plants 2024, 13(21), 3030; https://doi.org/10.3390/plants13213030 - 30 Oct 2024
Cited by 1 | Viewed by 1446
Abstract
This research investigates the morpho-anatomical characteristics of seven Baccharis species, namely B. articulata, B. milleflora, B. myriocephala, B. pentaptera, B. riograndensis, B. sagittalis and B. trimera. Commonly called carquejas, these species have aerial photosynthetic winged stems known [...] Read more.
This research investigates the morpho-anatomical characteristics of seven Baccharis species, namely B. articulata, B. milleflora, B. myriocephala, B. pentaptera, B. riograndensis, B. sagittalis and B. trimera. Commonly called carquejas, these species have aerial photosynthetic winged stems known as cladodes and are widely used traditionally to treat digestive and diuretic disorders. This study aimed to characterize these commonly misidentified species using morphological and microscopic techniques, including light and scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. Trichomes, the presence or absence of oil bodies, and a subepidermal collenchyma layer at the wing edge were identified as primary anatomical markers that can help differentiate the studied species. Full article
(This article belongs to the Special Issue Microscopy Techniques in Plant Studies)
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25 pages, 13138 KiB  
Article
Pro-Apoptotic and Anti-Cancer Activity of the Vernonanthura Nudiflora Hydroethanolic Extract
by Almog Nadir, Anna Shteinfer-Kuzmine, Swaroop Kumar Pandey, Juan Ortas, Daniel Kerekes and Varda Shoshan-Barmatz
Cancers 2023, 15(5), 1627; https://doi.org/10.3390/cancers15051627 - 6 Mar 2023
Cited by 4 | Viewed by 3543
Abstract
The mitochondrial voltage-dependent anion channel 1 (VDAC1) protein is involved in several essential cancer hallmarks, including energy and metabolism reprogramming and apoptotic cell death evasion. In this study, we demonstrated the ability of hydroethanolic extracts from three different plants, Vernonanthura nudiflora (Vern), Baccharis [...] Read more.
The mitochondrial voltage-dependent anion channel 1 (VDAC1) protein is involved in several essential cancer hallmarks, including energy and metabolism reprogramming and apoptotic cell death evasion. In this study, we demonstrated the ability of hydroethanolic extracts from three different plants, Vernonanthura nudiflora (Vern), Baccharis trimera (Bac), and Plantago major (Pla), to induce cell death. We focused on the most active Vern extract. We demonstrated that it activates multiple pathways that lead to impaired cell energy and metabolism homeostasis, elevated ROS production, increased intracellular Ca2+, and mitochondria-mediated apoptosis. The massive cell death generated by this plant extract’s active compounds involves the induction of VDAC1 overexpression and oligomerization and, thereby, apoptosis. Gas chromatography of the hydroethanolic plant extract identified dozens of compounds, including phytol and ethyl linoleate, with the former producing similar effects as the Vern hydroethanolic extract but at 10-fold higher concentrations than those found in the extract. In a xenograft glioblastoma mouse model, both the Vern extract and phytol strongly inhibited tumor growth and cell proliferation and induced massive tumor cell death, including of cancer stem cells, inhibiting angiogenesis and modulating the tumor microenvironment. Taken together, the multiple effects of Vern extract make it a promising potential cancer therapeutic. Full article
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15 pages, 1384 KiB  
Article
Baccharis trimera Infusion Reduces Macrophages Activation and High-Fat Diet-Induced Metabolic Disorders in Mice
by Thalita Vieira Nascimento Ximenes, Raquel Carvalho, Iluska Senna Bonfá, Vanessa Samúdio Santos, Luciane Candeloro, Flávio Macedo Alves, Denise Brentan Silva, Carlos Alexandre Carollo, Karine de Cássia Freitas Gielow, Saulo Euclides Silva-Filho and Mônica Cristina Toffoli-Kadri
Pharmaceuticals 2022, 15(10), 1258; https://doi.org/10.3390/ph15101258 - 13 Oct 2022
Cited by 4 | Viewed by 2892
Abstract
The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular [...] Read more.
The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H2O2), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea. Full article
(This article belongs to the Special Issue Ethnopharmacology in Latin America)
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19 pages, 2427 KiB  
Article
Antioxidant Baccharis trimera Leaf Extract Suppresses Lipid Accumulation in C. elegans Dependent on Transcription Factor NHR-49
by Flávia Roberta Monteiro Souza, Giovanna Melo Martins Silva, Cesar Orlando Muñoz Cadavid, Lucas dos Santos Lisboa, Maylla Maria Correia Leite Silva, Weslley Souza Paiva, Marcelo José Pena Ferreira, Riva de Paula Oliveira and Hugo Alexandre Oliveira Rocha
Antioxidants 2022, 11(10), 1913; https://doi.org/10.3390/antiox11101913 - 27 Sep 2022
Cited by 2 | Viewed by 3108
Abstract
Obesity is a global public health problem that is associated with oxidative stress. One of the strategies for the treatment of obesity is the use of drugs; however, these are expensive and have numerous side effects. Therefore, the search for new alternatives is [...] Read more.
Obesity is a global public health problem that is associated with oxidative stress. One of the strategies for the treatment of obesity is the use of drugs; however, these are expensive and have numerous side effects. Therefore, the search for new alternatives is necessary. Baccharis trimera is used in Brazilian folk medicine for the treatment of obesity. Here, B. trimera leaf extract (BT) showed antioxidant activity in seven in vitro tests, and it was not toxic to 3T3 murine fibroblasts or Caenorhabditis elegans. Furthermore, BT reduces the intracellular amount of reactive oxygen species and increases C. elegans survival. Moreover, these effects were not dependent on transcription factors. The inhibition of fat accumulation by BT in the C. elegans model was also investigated. BT reduced lipid accumulation in animals fed diets without or with high amount of glucose. Furthermore, it was observed using RNA interference (iRNA) that BT depends on the transcription factor NHR-49 to exert its effect. Phytochemical analysis of BT revealed rutin, hyperoside, and 5-caffeoylquinic acid as the main BT components. Thus, these data demonstrate that BT has antioxidant and anti-obesity effects. However, further studies should be conducted to understand the mechanisms involved in its action. Full article
(This article belongs to the Special Issue Natural Antioxidants in Obesity and Related Diseases)
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18 pages, 1547 KiB  
Article
Effects of Gender and Geographical Origin on the Chemical Composition and Antiradical Activity of Baccharis myriocephala and Baccharis trimera
by Suzana Struiving, Ana Carolina Mendes Hacke, Edésio Luiz Simionatto, Dilamara Riva Scharf, Cláudia Vargas Klimaczewski, Michele Aparecida Besten, Gustavo Heiden, Aline Augusti Boligon, João Batista Teixeira Rocha, José Carlos Rebuglio Vellosa, Domingos Sávio Nunes, Daniel Granato and Romaiana Picada Pereira
Foods 2020, 9(10), 1433; https://doi.org/10.3390/foods9101433 - 9 Oct 2020
Cited by 8 | Viewed by 2701
Abstract
This study aimed to characterize and compare essential oils and ethyl acetate fractions obtained in basic and acidic conditions from both male and female Baccharis species (Baccharis myriocephala and Baccharis trimera) from two different Brazilian regions. Samples were characterized according to [...] Read more.
This study aimed to characterize and compare essential oils and ethyl acetate fractions obtained in basic and acidic conditions from both male and female Baccharis species (Baccharis myriocephala and Baccharis trimera) from two different Brazilian regions. Samples were characterized according to their chemical compositions and antiradical activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Principal component analysis (PCA) provided a clear separation regarding the chemical composition of essential oils from the samples obtained from different regions by using gas chromatography–mass spectrometry with flame-ionization detection (GC-MS-FID). PCA also revealed that gender and region of plant collections did not influence the chemical composition and antiradical activity of ethyl acetate fractions, which was corroborated with hierarchical cluster analysis (HCA) data. High performance liquid chromatography with diode-array detector (HPLC-DAD) identified significant quantities of flavonoids and phenolic acids in the fractions obtained in basic and acidic fractions, respectively. The obtained results clearly demonstrated that the geographical region of plant collection influenced the chemical composition of essential oils from the studied Baccharis species. Moreover, the obtained fractions were constituted by several antiradical compounds, which reinforced the usage of these species in folk medicine. Full article
(This article belongs to the Section Food Quality and Safety)
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16 pages, 3172 KiB  
Article
Baccharis trimera (Less.) DC Exhibits an Anti-Adipogenic Effect by Inhibiting the Expression of Proteins Involved in Adipocyte Differentiation
by Daniele De Souza Marinho do Nascimento, Ruth Medeiros Oliveira, Rafael Barros Gomes Camara, Dayanne Lopes Gomes, Jessika Fernanda Santiago Monte, Mariana Santana Santos Pereira Costa, Júlia Moraes Fernandes, Silvana Maria Zucolotto Langassner and Hugo Alexandre Oliveira Rocha
Molecules 2017, 22(6), 972; https://doi.org/10.3390/molecules22060972 - 12 Jun 2017
Cited by 15 | Viewed by 5497
Abstract
Baccharis trimera (Less.) DC (gorse) is a plant popularly used for the treatment of obesity. In this study, we prepared three B. trimera extracts aqueous extract (AE), decoction (AE-D), and methanol extract (ME) and investigated their antioxidant effects in six different tests and [...] Read more.
Baccharis trimera (Less.) DC (gorse) is a plant popularly used for the treatment of obesity. In this study, we prepared three B. trimera extracts aqueous extract (AE), decoction (AE-D), and methanol extract (ME) and investigated their antioxidant effects in six different tests and their anti-adipogenic effect in 3T3-L1 cells. The extracts showed a dose-dependent antioxidant activity in all tests. AE was the most potent antioxidant in copper and ferric ion chelation assays, whereas AE-D was the most potent in superoxide and hydroxyl radical scavenging assays, reducing power assay, and total antioxidant capacity analysis. Only ME showed a cytotoxic effect against 3T3-L1 cells. Lipid accumulation decreased in 3T3-L1 adipocytes in the presence of AE and AE-D extracts (0.5 to 1.0 mg/mL). In addition, the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein α (C/EBPα), CCAAT enhancer-binding protein β (C/EBPβ), and gamma receptors by peroxisome proliferators (PPARγ), during adipogenesis. AE-D (1.0 mg/mL) caused an approximately 90% reduction in the levels of these molecules. We propose that B. trimera has an anti-adipogenic effect and could be used in the development of functional foods. Full article
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11 pages, 466 KiB  
Article
The Inhibitory Effects of Phenolic and Terpenoid Compounds from Baccharis trimera in Siha Cells: Differences in Their Activity and Mechanism of Action
by Cristiane B. De Oliveira, Lucimara N. Comunello, Érica S. Maciel, Scheron R. Giubel, Alessandra N. Bruno, Eduardo C. F. Chiela, Guido Lenz, Simone C. B. Gnoatto, Andréia Buffon and Grace Gosmann
Molecules 2013, 18(9), 11022-11032; https://doi.org/10.3390/molecules180911022 - 9 Sep 2013
Cited by 35 | Viewed by 7442
Abstract
Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory and antioxidant properties that are related to the presence of phenolic compounds. The aim of this work was to investigate the anti-proliferative properties of phenolic [...] Read more.
Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory and antioxidant properties that are related to the presence of phenolic compounds. The aim of this work was to investigate the anti-proliferative properties of phenolic (PHE) and terpenoid (SAP) compounds from B. trimera on human cervical cancer. The treatment of SiHa cells with PHE for 24 h suppressed colony formation in a dose-dependent manner, inhibited proliferation and inhibited cell motility. Although SAP inhibited the proliferation of SiHa cells in a dose-dependent manner, it increased colony formation and did not inhibit cell motility. PHE and SAP also promoted a significant increase in lactate dehydrogenase levels in the culture medium in a dose-dependent manner, indicating a loss of cell membrane integrity. Moreover, PHE promoted necrotic cell death, whereas SAP induced apoptosis. These compounds are new anticancer prototypes due their significant anticancer activity demonstrated herein. Full article
(This article belongs to the Section Natural Products Chemistry)
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11 pages, 246 KiB  
Article
Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities
by Cristiane B. De Oliveira, Lucimara N. Comunello, Adroaldo Lunardelli, Robson H. Amaral, Melissa G. S. Pires, Gabriela Lucas Da Silva, Vanusa Manfredini, Carmen Regla Vargas, Simone C. B. Gnoatto, Jarbas R. De Oliveira and Grace Gosmann
Molecules 2012, 17(1), 1113-1123; https://doi.org/10.3390/molecules17011113 - 23 Jan 2012
Cited by 46 | Viewed by 9590
Abstract
Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) [...] Read more.
Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds. Full article
(This article belongs to the Section Natural Products Chemistry)
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