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Keywords = Antarctic deep-sea derived fungus

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Article
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
by Guangwei Wu, Aiqun Lin, Qianqun Gu, Tianjiao Zhu and Dehai Li
Mar. Drugs 2013, 11(4), 1399-1408; https://doi.org/10.3390/md11041399 - 23 Apr 2013
Cited by 71 | Viewed by 9566
Abstract
A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 24, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D [...] Read more.
A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 24, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines. Full article
(This article belongs to the Special Issue Deep-Sea Natural Products)
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