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Following a tendency of many economies to shift towards carbon neutrality, there came the necessity for certain regions to be assessed in terms of their greenhouse gas emissions from the ocean. A carbon polygon was created in Sakhalin Oblast in order to evaluate the carbon balance of this marine ecosystem in a sub-arctic region, with the possibility of deploying carbon farms for additional CO₂ absorption. To obtain such an assessment, it seems crucial to analyze hydrochemical parameters that reflect the situation of the marine environment in Aniva Bay as a basis of the carbon polygon. The article presents the results of the analysis of hydrochemical parameters in Aniva Bay waters and their spatial and seasonal variability. This research was based on available published sources and measurement databases for the period of 1948–1994. Additionally, the review uses hydrochemical data for Aniva Bay in 2001–2013 weather station data for the period of 2008–2023 and weather station data for 2008–2023. Some tendencies were discovered for spatial and temporal distributions of oxygen, pH, and biogenic matter (inorganic phosphorus, inorganic nitrogen, silicon). In surface layers, the mean oxygen year maximum (9.1 mg/L) is registered with the beginning of photosynthesis, i.e., immediately after the ice melting in April. The highest pH values 8.26 are registered in the euphotic layer in May. The lowest pH values was in August (7.96) in the near-bottom layer. The maximum annual P-PO4 registered on the surface (>18 µg/L) immediately after ice melting, with a minimum (7.17 µg/L) at the end of July. Si-SiO₃ concentrations have two maximums: at the end of June and at the beginning of October. N-NO2 concentration on the surface is >2 µg/L in mid-July and on the 50 m depth it is >3.5 µg/L in mid-September. Some spatial patterns of hydrochemical parameters were shown based on the analysis of maps. Full article

Cerebrosides are glycosylated sphingolipids, and in mammals they contribute to the pro-/anti-inflammatory properties and innate antimicrobial activity of the skin and mucosal surfaces. Staphylococcus aureus infection can develop, not only from minor scratches of the skin, but this pathogen can also actively promote epithelial breach. The effect of cerebroside flavuside B from marine sediment-derived fungus Penicillium islandicum (Aniva Bay, the Sea of Okhotsk) on viability, apoptosis, total caspase activity, and cell cycle in human epidermal keratinocytes HaCaT line co-cultivated with S. aureus, as well as influence of flavuside B on LPS-treated HaCaT cells were studied. Influence of flavuside B on bacterial growth and biofilm formation of S. aureus and its effect on the enzymatic activity of sortase A was also investigated. It was found S. aureus co-cultivated with keratinocytes induces caspase-depended apoptosis and cell death, arrest cell cycle in the G0/G1 phase, and increases in cellular immune inflammation. Cerebroside flavuside B has demonstrated its antimicrobial and anti-inflammatory properties, substantially eliminating all the negative consequences caused by co-cultivation of keratinocytes with S. aureus or bacterial LPS. The dual action of flavuside B may be highly effective in the treatment of bacterial skin lesions and will be studied in the future in in vivo experiments. Full article