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Keywords = ALK-wildtype and aberrations in immunity

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15 pages, 1319 KB  
Review
Emerging Roles of ALK in Immunity and Insights for Immunotherapy
by Lan Wang and Vivian Wai Yan Lui
Cancers 2020, 12(2), 426; https://doi.org/10.3390/cancers12020426 - 12 Feb 2020
Cited by 27 | Viewed by 6366
Abstract
Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches [...] Read more.
Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. Here, we provide a timely review on the most updated laboratory and patient-related findings on ALK and immunity, which would grant us important insights for the development of novel ALK immunotherapies for ALK-altered cancers. Full article
(This article belongs to the Special Issue ALK: A Tyrosine Kinase Target for Cancer Therapy)
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