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Keywords = 2-benzyl-4(1H)-quinolone

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6 pages, 1741 KiB  
Communication
Attempted Synthesis of the Pseudomonas aeruginosa Metabolite 2-Benzyl-4(1H)-quinolone and Formation of 3-Methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an Unexpected Product
by Plamen Angelov, Yordanka Mollova-Sapundzhieva and Paraskev Nedialkov
Molbank 2024, 2024(3), M1877; https://doi.org/10.3390/M1877 - 29 Aug 2024
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Abstract
The unusual reactivity of key enamine intermediates led to the formation of 3-methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an unexpected product in an attempted synthesis of the P. aeruginosa metabolite 2-benzyl-4(1H)-quinolone. Although the synthesis of the natural product has not been successful, this [...] Read more.
The unusual reactivity of key enamine intermediates led to the formation of 3-methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an unexpected product in an attempted synthesis of the P. aeruginosa metabolite 2-benzyl-4(1H)-quinolone. Although the synthesis of the natural product has not been successful, this methodology allows for the easy preparation of novel derivatives carrying a carboxamide moiety at the C3 position. Full article
(This article belongs to the Section Organic Synthesis and Biosynthesis)
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