Search Results (6)

The simulation results presented based on the proposed system demonstrated significant improvements in communication reliability, packet loss reduction and signal stability, highlighting its superiority in real urban traffic conditions. Using the IEEE 802.11p standard and a modular dual-antenna architecture, the system maintained a latency below 10 ms over distances of over 3 km, without noticeable signal loss. GNSS synchronization ensured precise vehicle positioning and dynamic signal optimization. There are results and approaches that highlight the limitations of IEEE 802.11p in dense traffic scenarios; the current approach has reduced packet loss to below 5%. Its integration also allows compatibility with future technologies such as 5G and C-V2X, guaranteeing scalability and long-term relevance. The proposed prototype sets a new standard in vehicular communications, combining high performance with a flexible and extensible architecture, making it a viable solution for large-scale deployments in smart cities, supporting the transition to safer and more sustainable transportation infrastructures. Full article

Subsurface drainage pipes covered with filters and geotextiles are the key to preventing clogging and ensuring efficient drainage. To improve the salt discharge efficiency of these subsurface drainage pipes, different layers of geotextiles were set outside the pipes with the aid of uniform gravel filters. This paper reports our findings from laboratory simulation of subsurface drainage pipes and experiments. The study examined the influence of different layers of geotextiles on the drainage efficiency, salt discharge effects of subsurface drainage pipes, and the effect of superimposed geotextiles on the salt drainage efficiency as well as the anti-clogging effect of subsurface drainage pipes. The results are as follows: (1) The geotextile and filter material wrapped around the subsurface pipe facilitated the movement of water towards the subsurface pipe, which could promote the salt discharge of the subsurface pipe. However, in the single leaching experiment, the reduction in soil pH was not significant for different scenarios. (2) The salt removal rate of the geotextile-wrapped subsurface pipes was more than 95%. The salt removal rate of the double-layer geotextile scenario was the highest (96.7%), and the total salt content of soil profiles was 8.3% and 31.3% lower than those of the single-layer and triple-layer geotextile scenarios, respectively. The drainage efficiency of the double-layer geotextile scenario was the highest, and the salt distribution in the 0–60 cm profile was relatively uniform, ranging from 2.3 to 3.0 g∙kg⁻¹. (3) The clogging in the triple-layer geotextile scenario was caused by the geotextile, i.e., a dense filter cake layer formed on the surface of the geotextile. The clogging in the single-layer and double-layer geotextile scenarios was the clogging of the geotextile itself, i.e., soil particles retained in the fiber structure of geotextiles. (4) In the case of the single-layer and double-layer geotextile scenarios, the soil particles failed to completely clog the selected geotextiles, and there were still a large number of pores retained. The double-layer geotextiles integrate filtration, clogging prevention, and drainage promotion to provide the best salt drainage with the subsurface pipe. This study reveals the influence of the filter on soil water salt and salt discharge and provides a theoretical explanation and technical justification for the application of the subsurface pipes salt discharge technology in saline soil ameliorate. Full article

In this research article, we define some categories of open sets over a generalized topological space given together with a primal collection. In addition, we clarify some of its characteristics and investigate the relationships between these concepts in the space under consideration. The topic of continuity occupies a large space in topological theory and is one of the most important topics therein. Researchers have examined it in light of many variables. We followed the same approach by studying the concept of continuity between two generalized topological spaces in light of the primal collection under the name $(\mathfrak{g},\mathcal{P})$-continuity. We also made a decomposition of this type of function in light of these weak categories of open sets. Full article

Human cytomegalovirus (HCMV) infection is associated with severe disease conditions either following congenital transmission of the virus or viral reactivation in immunosuppressed individuals. Consequently, the establishment of a protective vaccine is of high medical need. Several candidates have been tested in preclinical and clinical studies, yet no vaccine has been licensed. Subviral dense bodies (DB) are a promising vaccine candidate. We have recently provided a GMP-compliant protocol for the production of DB, based on a genetically modified version of the HCMV laboratory strain Towne, expressing the pentameric complex of envelope protein gH-gL-pUL128-131 (Towne-UL130rep). In this work, we genetically attenuated Towne-UL130rep by abrogating the expression of the tegument protein pUL25 and by fusing the destabilizing domain ddFKBP to the N-terminus of the IE1- and IE2-proteins of HCMV. The resulting strain, termed TR-VAC, produced high amounts of DB under IE1/IE2 repressive conditions and concomitant supplementation of the viral terminase inhibitor letermovir to the producer cell culture. TR-VAC DB retained the capacity to induce neutralizing antibodies. A complex pattern of host protein induction was observed by mass spectrometry following exposure of primary human monocytes with TR-VAC DB. Human monocyte-derived dendritic cells (DC) moderately increased the expression of activation markers and MHC molecules upon stimulation with TR-VAC DB. In a co-culture with autologous T cells, the TR-VAC DB-stimulated DC induced a robust HCMV-specific T cell-activation and –proliferation. Exposure of donor-derived monocytic cells to DB led to the activation of a rapid innate immune response. This comprehensive data set thus shows that TR-VAC is an optimal attenuated seed virus strain for the production of a DB vaccine to be tested in clinical studies. Full article

The Dietary Guidelines for Americans recommends giving priority to nutrient-dense foods while decreasing energy-dense foods. Although both flax (Linum usitatissimum) and sorghum (Sorghum bicolor) are rich in various essential minerals, their ionomes have yet to be investigated. Furthermore, previous studies have shown that elevated CO₂ levels could reduce key nutrients in crops. In this study, we analyzed 102 flax and 108 sorghum varieties to investigate their ionomic variations (N, P, K, Ca, Mg, S, B, Zn, Mn, Fe, Cu, and Mo), elemental level interactions, and nutritional value. The results showed substantial genetic variations and elemental correlations in flax and sorghum. While a serving size of 28 g of flax delivers 37% daily value (DV) of Cu, 31% of Mn, 28% of Mg, and 19% of Zn, sorghum delivers 24% of Mn, 16% of Cu, 11% of Mg, and 10% of Zn of the recommended daily value (DV). We identified a set of promising flax and sorghum varieties with superior seed mineral composition that could complement breeding programs for improving the nutritional quality of flax and sorghum. Overall, we demonstrate additional minerals data and their corresponding health and food security benefits within flax and sorghum that could be considered by consumers and breeding programs to facilitate improving seed nutritional content and to help mitigate human malnutrition as well as the effects of rising CO₂ stress. Full article

Evidence shows that multiple factors, such as socio-economic status and access to health care facilities, affect tuberculosis (TB) incidence. However, there is limited literature available with respect to the correlation between socio-economic/health facility factors and tuberculosis incidence. This study aimed to explore the relationship between TB incidence and socio-economic/health service predictors in the study settings. A retrospective spatial regression analysis was carried out based on new sputum smear-positive pulmonary TB cases in Beijing districts. Global Moran’s I analysis was adopted to detect the spatial dependency followed by spatial regression models (spatial lag model, and spatial error model) along with the ordinary least square model were applied to examine the correlation between TB incidence and predictors. A high incidence of TB was seen in densely populated districts in Beijing, e.g., Haidian, Mentougou, and Xicheng. After comparing the R², log-likelihood, and Akaike information criterion (AIC) values among three models, the spatial error model (R² = 0.413; Log Likelihood = −591; AIC = 1199.76) identified the best model fit for the spatial regression model. The study showed that the number of beds in health institutes (p < 0.001) and per capita gross domestic product (GDP) (p = 0.025) had a positive effect on TB incidence, whereas population density (p < 0.001) and migrated population (p < 0.001) had an adverse impact on TB incidence in the study settings. High TB incidence districts were detected in urban and densely populated districts in Beijing. Our findings suggested that socio-economic predictors influence TB incidence. These findings may help to guide TB control programs and promote targeted intervention. Full article