Three copper(I) dithiocarbamate–phosphine complexes of the general formula Cu(PPh
3)
2L were synthesized by metathesis reactions of the potassium salt of the dithiocarbamate ligand
L and the precursor complex Cu(PPh
3)
2NO
3 in an equimolar ratio.
L represents
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Three copper(I) dithiocarbamate–phosphine complexes of the general formula Cu(PPh
3)
2L were synthesized by metathesis reactions of the potassium salt of the dithiocarbamate ligand
L and the precursor complex Cu(PPh
3)
2NO
3 in an equimolar ratio.
L represents N,N′-bis(2,6-dimethylphenyl)formamidine dithiocarbamate
L1 in complex
1, N,N′-bis(2,6-disopropylphenyl) formamidine dithiocarbamate
L2 in complex
2, and N,N′-dimesitylformamidine dithiocarbamate
L3 in complex
3. The single-crystal X-ray structure revealed the coordination of the copper atom to two sulfur atoms of the dithiocarbamates, as well as two phosphorus atoms of the PPh
3 units, which resulted in distorted tetrahedral geometries. The calculated τ
4 (tau factor) values for
1,
2 and
3 were 0.82, 0.81 and 0.85, respectively, confirming the pseudo-tetrahedral geometry proposed. Complexes
1–
3 showed remarkable luminescent properties in CH
2Cl
2 at room temperature. All three complexes showed moderate-to-low antibacterial potential against Gram-negative bacteria, while none of the complexes were active against Gram-positive bacteria. The DPPH assay studies showed that complex
2 had the lowest IC
50 (4.99 × 10
−3 mM),and had higher DPPH free radical scavenging ability than
1 and
3. The pharmacological estimations of
1–
3 showed that all of the complexes showed minimal violation of Lipinski’s rule.
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