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Authors = Peter Lundqvist

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11 pages, 1486 KiB  
Article
Low Fasting Concentrations of Glucagon in Patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
by Rasmus Stenlid, Hannes Manell, Rikard Seth, Sara Y. Cerenius, Azazul Chowdhury, Camilla Roa Cortés, Isabelle Nyqvist, Thomas Lundqvist, Maria Halldin and Peter Bergsten
Metabolites 2023, 13(7), 780; https://doi.org/10.3390/metabo13070780 - 22 Jun 2023
Cited by 1 | Viewed by 1961
Abstract
(1) Background: Deficiencies of mitochondrial fatty acid oxidation (FAO) define a subgroup of inborn errors of metabolism, with medium-chain acyl-CoA dehydrogenase deficiency (MCAD) and very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) being two of the most common. Hypoketotic hypoglycemia is a feared clinical complication [...] Read more.
(1) Background: Deficiencies of mitochondrial fatty acid oxidation (FAO) define a subgroup of inborn errors of metabolism, with medium-chain acyl-CoA dehydrogenase deficiency (MCAD) and very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) being two of the most common. Hypoketotic hypoglycemia is a feared clinical complication and the treatment focuses on avoiding hypoglycemia. In contrast, carnitine uptake deficiency (CUD) is treated as a mild disease without significant effects on FAO. Impaired FAO has experimentally been shown to impair glucagon secretion. Glucagon is an important glucose-mobilizing hormone. If and how glucagon is affected in patients with VLCAD or MCAD remains unknown. (2) Methods: A cross-sectional study was performed with plasma hormone concentrations quantified after four hours of fasting. Patients with VLCAD (n = 10), MCAD (n = 7) and CUD (n = 6) were included. (3) Results: The groups were similar in age, sex, weight, and height. The glucagon and insulin levels were significantly lower in the VLCAD group compared to the CUD group (p < 0.05, respectively). The patients with CUD had glucagon concentrations similar to the normative data. No significant differences were seen in GLP-1, glicentin, glucose, amino acids, or NEFAs. (4) Conclusions: Low fasting concentrations of glucagon are present in patients with VLCAD and cannot be explained by altered stimuli in plasma. Full article
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5 pages, 707 KiB  
Editorial
Sustainable Healthy Working Life for All Ages—Work Environment, Age Management and Employability
by Kerstin Nilsson, Clas-Håkan Nygård, Tove Midtsundstad, Peter Lundqvist and Joanne Crawford
Int. J. Environ. Res. Public Health 2023, 20(3), 2712; https://doi.org/10.3390/ijerph20032712 - 3 Feb 2023
Cited by 3 | Viewed by 3116
Abstract
The proportion of elderly citizens is continuously increasing in most of the industrial world [...] Full article
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1 pages, 138 KiB  
Abstract
The Effect of SAP and POSS Additives on the Durability of Concrete in Artic Environments
by Peter Lundqvist
Proceedings 2019, 34(1), 21; https://doi.org/10.3390/proceedings2019034021 - 18 Nov 2019
Viewed by 1119
Abstract
In an on-going European project LORCENIS, which focus on the development of durable concrete structures, different types of innovative additives have been tested for use in concrete. As a part of this project the effect of super absorbent polymers (SAP) and polyhedral silsequioxanes [...] Read more.
In an on-going European project LORCENIS, which focus on the development of durable concrete structures, different types of innovative additives have been tested for use in concrete. As a part of this project the effect of super absorbent polymers (SAP) and polyhedral silsequioxanes (POSS) on different durability issues was investigated in laboratory tests. In this study the focus was on the application for large concrete structures in arctic environments, e.g., hydro power dams. The purpose was to investigate the effect of the additives on two durability issues: the combination of leaching and freeze-thaw and the self-healing of cracks under hydro static water pressure. In addition, the influence of the additives on the fresh and hardened properties of the concrete was also investigated, this included e.g., flow characteristics, compressive strength and volume stability. As basis for the tests, a concrete mix suitable for use for large concrete structures was developed within the project. In this paper, the results and conclusions from the laboratory tests will be presented. Full article
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