MDPI - Publisher of Open Access Journals

20 pages, 362 KiB

Open AccessFeature PaperEditor’s ChoiceReview

Attachment, Mentalizing and Trauma: Then (1992) and Now (2022)

by Peter Fonagy, Chloe Campbell and Patrick Luyten

Brain Sci. 2023, 13(3), 459; https://doi.org/10.3390/brainsci13030459 - 8 Mar 2023

Cited by 37 | Viewed by 16064

This article reviews the current status of research on the relationship between attachment and trauma in developmental psychopathology. Beginning with a review of the major issues and the state-of-the-art in relation to current thinking in the field of attachment about the impact of trauma and the inter-generational transmission of trauma, the review then considers recent neurobiological work on mentalizing and trauma and suggests areas of new development and implications for clinical practice. Full article

(This article belongs to the Special Issue State of the Art in Human Attachment)

12 pages, 1446 KiB

Open AccessArticle

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae

by Purity N. Kipanga, Liesbeth Demuyser, Johannes Vrijdag, Elja Eskes, Petra D’hooge, Josphat Matasyoh, Geert Callewaert, Joris Winderickx, Patrick Van Dijck and Walter Luyten

Int. J. Mol. Sci. 2021, 22(11), 5756; https://doi.org/10.3390/ijms22115756 - 28 May 2021

Cited by 5 | Viewed by 3890

Abstract

Polygodial is a “hot” peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to shed more light on polygodial’s antifungal mechanism of action. We identified 66 deletion strains that were hypersensitive and 47 that were highly resistant to polygodial treatment. Among the hypersensitive strains, an enrichment was found for genes required for vacuolar acidification, amino acid biosynthesis, nucleosome mobilization, the transcription mediator complex, autophagy and vesicular trafficking, while the resistant strains were enriched for genes encoding cytoskeleton-binding proteins, ribosomal proteins, mitochondrial matrix proteins, components of the heme activator protein (HAP) complex, and known regulators of the target of rapamycin complex 1 (TORC1) signaling. WE confirm that polygodial triggers a dose-dependent vacuolar alkalinization and that it increases Ca²⁺ influx and inhibits glucose-induced Ca²⁺ signaling. Moreover, we provide evidence suggesting that TORC1 signaling and its protective agent ubiquitin play a central role in polygodial resistance, suggesting that they can be targeted by polygodial either directly or via altered Ca²⁺ homeostasis. Full article

(This article belongs to the Special Issue Bioactive Plant Secondary Metabolites)

► Show Figures

Figure 1

36 pages, 1944 KiB

Open AccessFeature PaperArticle

Improving the Translation Environment for Professional Translators

by Vincent Vandeghinste, Tom Vanallemeersch, Liesbeth Augustinus, Bram Bulté, Frank Van Eynde, Joris Pelemans, Lyan Verwimp, Patrick Wambacq, Geert Heyman, Marie-Francine Moens, Iulianna van der Lek-Ciudin, Frieda Steurs, Ayla Rigouts Terryn, Els Lefever, Arda Tezcan, Lieve Macken, Véronique Hoste, Joke Daems, Joost Buysschaert, Sven Coppers, Jan Van den Bergh and Kris Luyten Show full author list Hide full author list

Informatics 2019, 6(2), 24; https://doi.org/10.3390/informatics6020024 - 20 Jun 2019

Cited by 7 | Viewed by 13328

Abstract

When using computer-aided translation systems in a typical, professional translation workflow, there are several stages at which there is room for improvement. The SCATE (Smart Computer-Aided Translation Environment) project investigated several of these aspects, both from a human-computer interaction point of view, as well as from a purely technological side. This paper describes the SCATE research with respect to improved fuzzy matching, parallel treebanks, the integration of translation memories with machine translation, quality estimation, terminology extraction from comparable texts, the use of speech recognition in the translation process, and human computer interaction and interface design for the professional translation environment. For each of these topics, we describe the experiments we performed and the conclusions drawn, providing an overview of the highlights of the entire SCATE project. Full article

(This article belongs to the Special Issue Advances in Computer-Aided Translation Technology)

► Show Figures

Figure 1

Search Results (3)

Further Information

Guidelines

MDPI Initiatives

Follow MDPI

Saved Queries

Search Filter Reset All

Years

Feature Papers

Subjects

Journals

Article Types

Countries / Regions

Search Results (3)

Further Information

Guidelines

MDPI Initiatives

Follow MDPI