Search Results (6)

Background: Existing evidence suggests a close link among high levels of serum urate (SU), obesity and carotid atherosclerosis. The aim of the present study was to evaluate the interrelations between SU levels and carotid atherosclerosis in subjects with different obesity phenotypes. Methods: In this study, a total of 2076 subjects (mean age 48.1 ± 13.1 years; 1307 women) were recruited: 59 with general obesity, 616 with central obesity, 715 with mixed (general–central) obesity and 686 non-obese. Anthropometric measurements, vascular risk factors, blood biochemistry analysis (including SU levels), and carotid ultrasound were performed. Ultrasound assessment included evaluation of intima-media thickness (IMT) and plaque characteristics, including number, total area and type (vulnerable vs. stable) of plaques. Results: After adjustment for potential confounders, the highest levels of SU were observed in subjects with mixed obesity, followed by subjects with central obesity, general obesity and the non-obese (309.4 ± 82.2 vs. 301.2 ± 73.1 vs. 272.9 ± 61.8 vs. 234.2 ± 59.8 μmol/L, respectively; F = 149.2, post hoc p < 0.001). Similarly, subjects with mixed and central obesity presented higher values of IMT compared to subjects with general obesity and the non-obese (0.68 ± 0.16 vs. 0.67 ± 0.16 vs. 0.62 ± 0.14 vs. 0.57 ± 0.13 mm, respectively; F = 54.2, post hoc p < 0.001). No difference in number, total area and type of plaques among obesity groups were attested (all p > 0.05). Significantly higher IMT values were observed in subjects with increased SU levels compared to subjects with normal SU levels (0.70 ± 0.10 vs. 0.62 ± 0.14 mm, p = 0.02) only within the central obesity group. Increasing levels of SU were associated with a higher frequency of increased IMT only in subjects with central obesity (OR 1.033, 95% CI 1.025–1.041). Similarly, SU levels yielded a satisfactory performance in detecting subjects with increased IMT (AUC 0.65, 95% CI 0.50–0.73, subjects with carotid plaques (0.62, 95% CI 0.55–0.68) and subjects with vulnerable plaque types (0.68, 0.59–0.76) only within the central obesity group. Conclusions: Among the studied obesity types, the association between SU levels and markers of carotid atherosclerosis was of particular significance in subjects with central obesity. Full article

Studies show that the autonomic nervous system (ANS) has an important impact on health in general. In response to environmental demands, homeostatic processes are often compromised, therefore determining an increase in the sympathetic nervous system (SNS)’s functions and a decrease in the parasympathetic nervous system (PNS)’s functions. In modern societies, chronic stress associated with an unhealthy lifestyle contributes to ANS dysfunction. In this review, we provide a brief introduction to the ANS network, its connections to the HPA axis and its stress responses and give an overview of the critical implications of ANS in health and disease—focused specifically on the immune system, cardiovascular, oxidative stress and metabolic dysregulation. The hypothalamic–pituitary–adrenal axis (HPA), the SNS and more recently the PNS have been identified as regulating the immune system. The HPA axis and PNS have anti-inflammatory effects and the SNS has been shown to have both pro- and anti-inflammatory effects. The positive impact of physical exercise (PE) is well known and has been studied by many researchers, but its negative impact has been less studied. Depending on the type, duration and individual characteristics of the person doing the exercise (age, gender, disease status, etc.), PE can be considered a physiological stressor. The negative impact of PE seems to be connected with the oxidative stress induced by effort. Full article

The electrospun nanosystems containing poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and 1 wt% Fe doped ZnO nanoparticles (NPs) (with the content of dopant in the range of 0–1 wt% Fe) deposited onto polylactic acid (PLA) film were prepared for food packaging application. They were investigated by scanning electron microscopy (SEM), energy dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), antimicrobial analysis, and X-ray photoelectron spectrometry (XPS) techniques. Migration studies conducted in acetic acid 3% (wt/wt) and ethanol 10% (v/v) food simulants as well as by the use of treated ashes with 3% HNO₃ solution reveal that the migration of Zn and Fe falls into the specific limits imposed by the legislation in force. Results indicated that the PLA/PHBV/ZnO:Fex electrospun nanosystems exhibit excellent antibacterial activity against the Pseudomonas aeruginosa (ATCC-27853) due to the generation of a larger amount of perhydroxyl (˙OOH) radicals as assessed using electron paramagnetic resonance (EPR) spectroscopy coupled with a spin trapping method. Full article

The aim of this article is to present a nonconventional method for the efficient removal of lead ions from industrial wastewater. For this purpose, magnetite nanomaterial was used, which was very easily separated from the wastewater at the end of the treatment due to its magnetic properties. Currently, nanotechnology is an efficient and inexpensive manner that is being researched for wastewater treatment. Additionally, iron oxide nanoparticles are widely used to remove heavy metal ions from water due to their special properties. The experimental results detailed in this article show the influence of pH and contact time on the process of adsorption of lead ions from wastewater. The magnetite nanomaterial had its maximum efficiency of speed when the wastewater had pH 6. At a lower pH, the highest treatment efficiency was over 85%, and the required contact time has doubled. When the pH increases above 6, the precipitation process occurs. Langmuir and Freundlich models were used to describe the adsorption process. Full article

Olive mill wastes continue to be a management challenge due to the large volumes produced, particularly due to their toxicity and impacts on the environment. Thermal conversion through pyrolysis or hydrothermal carbonization techniques can detoxify wastes while conserving nutrient contents. In this work, we produced up-to-date data on olive mill waste flows in Spain, Tunisia, and Greece and characterized representative samples in the laboratory. Assays of thermal conversion of olive mill wastewaters and solid wastes were also performed to understand biochar yields and final properties, and the total quantities of nutrients contained were estimated. Of particular note were the quantities of potassium in Tunisian wastewaters, representing 0.6% of the total mass and an annual flow of approximately 5000 t, and in the Spanish solid wastes, an average of 1.7% of the total mass is potassium, representing an annual flow of approximately 23,000 t. Concerning phosphorus, Spanish solid wastes had the highest contents (0.1%), double that of other countries’ wastes. Annually, olive mill wastes from the three countries are estimated to contain approximately 35 × 10³ tons of potassium and 2.6 × 10³ tons of phosphorus. With this resource converted to biochar, each year more than 700 km² of soils could be enriched in 0.2% carbon with biochar at an application rate of 7 t ha⁻¹. Full article

The local turn to food is often claimed to be a way to increase the value-added component retained by primary producers and to provide healthy, fresh and affordable food to consumers. Rio do Grande do Sul in Brazil has several governmental support programs that aim to empower family farmers and open up new market opportunities for them. This article examines these programs, investigates how small-scale farmers engage with them and the resultant changes in farming and marketing practices that ensue. The article uses cluster and content analysis to identify and interpret the extent, and the different ways, in which these farmers engage with and make use of the local knowledge and innovation system. The results provide useful insights into how policy instruments improve the performance of family agribusinesses, helping them to make better use of the resources available to them, encouraging farm diversification, and strengthening local interrelations between producers and consumers. Full article