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Authors = Lirio Milenka Arévalo-Soliz

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22 pages, 792 KiB  
Review
Advances in Non-Viral DNA Vectors for Gene Therapy
by Cinnamon L. Hardee, Lirio Milenka Arévalo-Soliz, Benjamin D. Hornstein and Lynn Zechiedrich
Genes 2017, 8(2), 65; https://doi.org/10.3390/genes8020065 - 10 Feb 2017
Cited by 300 | Viewed by 21080
Abstract
Uses of viral vectors have thus far eclipsed uses of non-viral vectors for gene therapy delivery in the clinic. Viral vectors, however, have certain issues involving genome integration, the inability to be delivered repeatedly, and possible host rejection. Fortunately, development of non-viral DNA [...] Read more.
Uses of viral vectors have thus far eclipsed uses of non-viral vectors for gene therapy delivery in the clinic. Viral vectors, however, have certain issues involving genome integration, the inability to be delivered repeatedly, and possible host rejection. Fortunately, development of non-viral DNA vectors has progressed steadily, especially in plasmid vector length reduction, now allowing these tools to fill in specifically where viral or other non-viral vectors may not be the best options. In this review, we examine the improvements made to non-viral DNA gene therapy vectors, highlight opportunities for their further development, address therapeutic needs for which their use is the logical choice, and discuss their future expansion into the clinic Full article
(This article belongs to the Special Issue Gene Therapy)
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