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13 pages, 1974 KiB

Open AccessArticle

Nephroprotective and Antioxidant Effects of Jatropha dioica Extract Against Ischemia–Reperfusion Injury in Wistar Rats

by Diana Raquel Rodríguez-Rodríguez, Oscar Humberto Mendoza-Hernández, Paula Cordero-Pérez, Verónica Mayela Rivas-Galindo, Diana Patricia Moreno-Peña, Ramiro Tijerina-Márquez, Alondra Michelle Garza-Villarreal, Gabriela Alarcón-Galván, Linda Elsa Muñoz-Espinosa, Homero Arturo Zapata-Chavira, Marco Antonio Hernández-Guedea, Guadalupe Yazmín Solis-Cruz and Liliana Torres-González

Int. J. Mol. Sci. 2025, 26(5), 1838; https://doi.org/10.3390/ijms26051838 - 21 Feb 2025

Cited by 1 | Viewed by 1000

Abstract

Plant extracts with antioxidant activities have shown nephroprotection against IR injury. Jatropha dioica (Jd) possesses antioxidant activity. Our aim was to evaluate the effects of a hydroalcoholic Jd extract against IR injury in Wistar rats. Rats were divided into groups (n = 6): sham (SH); no toxicity (JdTox; 300 mg/kg/day of extract for 7 days); IR (on day 7 [I: 45 min/R: 24 h]); and Jd+IR (same treatment as JdTox; same surgical procedure as IR). AST and LDH were significantly lower in the JdTox. IR exhibited significantly higher CrS, BUN, and MDA compared with SH; Jd+IR showed reductions in these markers. GSH and SOD levels were significantly lower in IR compared with SH; an increase in these markers was observed in the Jd+IR. Histologically, IR showed significant increases in medullary tubular necrosis, medullary protein casts, and medullary vascular congestion compared with SH and JdTox. In Jd+IR, a significant decrease was observed only in medullary tubular necrosis. Therefore, the evaluated hydroalcoholic Jd extract dose showed no nephrotoxicity and hepatotoxicity. Jd extract pretreatment attenuated IR-induced renal injury, as evidenced by the improved serum markers of renal damage and oxidative stress. Full article

(This article belongs to the Special Issue Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 2nd Edition)

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15 pages, 2881 KiB

Open AccessArticle

Antidiabetic and Anti-Inflammatory Effect of Cinnamomum cassia Oil in Alloxan-Induced Diabetic Rats

by Paula Cordero-Pérez, Flor Edith Hernández-Cruz, Daniel Garza-Guzmán, Diana Patricia Moreno-Peña, Concepción Sánchez-Martínez, Liliana Torres-González, Linda E. Muñoz-Espinosa, Homero Zapata-Chavira, Idalia Cura-Esquivel, Marisol Idalí Serrano-Sandoval and Diana Raquel Rodríguez-Rodríguez

Pharmaceuticals 2024, 17(9), 1135; https://doi.org/10.3390/ph17091135 - 29 Aug 2024

Cited by 2 | Viewed by 2214

Abstract

Diabetes mellitus presents a great diversity of treatments that cause adverse effects; therefore, plants are a source of compounds that may have fewer adverse effects; Cinnamomum cassia (C. cassia) has compounds with potential antidiabetic activity. The objective was to evaluate the antidiabetic effect of C. cassia oil (CCO) and its impact on oxidative stress in Wistar rats. Five groups were evaluated: (1) sham (SH), (2) 300 mg/kg CCO (CCO), (3) diabetic (D) induced with alloxan, (4) D + 300 mg/kg of CCO (D + CCO), and (5) D + 500 mg/kg of metformin (D + MET); all were treated for 5 days. CCO did not show alteration in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) vs. SH. D + CCO vs. D significantly reduced glucose (333 ± 109 vs. 458 ± 81 mg/dL), ALT (66 ± 15 vs. 160 ± 54 U/L), AST (119 ± 26 vs. 243 ± 104 U/L), and blood urea nitrogen (18.8 ± 2.3 vs. 29.2 ± 6.9 mg/dL). No significant changes were observed in D + CCO vs. D in malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD), whereas a significant reduction in MDA and GSH was achieved in D + MET, with an increase in SOD. There was a reduction in Rela and Gpx in D + CCO and D + MET vs. D. CCO has antidiabetic and anti-inflammatory effects and reduces ALT, AST, and BUN levels. Full article

(This article belongs to the Special Issue Discovery of Natural Products as Potential Antidiabetic Agents)

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19 pages, 3867 KiB

Open AccessEditor’s ChoiceArticle

Perstraction: A Membrane-Assisted Liquid–Liquid Extraction of PFOA from Water

by Catherine B. Almquist, Linda Garza, Megan Flood, Anne Carroll, Ryan Armstrong, Sean Chen and Christopher Marcellino

Processes 2023, 11(1), 217; https://doi.org/10.3390/pr11010217 - 10 Jan 2023

Cited by 1 | Viewed by 5698

Abstract

This study represents a first time that perstraction was assessed as a process to remove perfluorooctanoic acid (PFOA) from water. In the perstraction process, PFOA permeates through a membrane from water to a solvent. The membrane used in this study was polydimethylsiloxane (PDMS). The experimental approach included the following: (1) measurement of partition coefficients for PFOA between water and selected solvents; (2) determination of solubility and diffusivity of the solvents in PDMS; (3) determination of the uptake of PFOA in PDMS; (4) determination of the effects of selected particles imbedded in the PDMS on PFOA uptake and solvent absorption; and (5) demonstration of the perstraction process to remove PFOA from water. PFOA preferentially partitioned to alcohols over water. In addition, ZnO and CuO particles in PDMS significantly enhanced the rate at which PFOA was absorbed in PDMS from deionized water due to ionic interactions. The perstraction of PFOA from deionized water into hexanol was demonstrated. However, perstraction was not successful at removing PFOA from tap water. While the application of perstraction to removing PFOA from water is limited, the idea was demonstrated and information contained within this manuscript is new. Full article

(This article belongs to the Section Separation Processes)

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12 pages, 3426 KiB

Open AccessProceeding Paper

UV-LED Photocatalytic Device for the Oxidation of Ethanol and Hexane Vapors in Air

by Catherine B. Almquist, Isabelle O’Hare, Linda Garza, Akram Badahman, Will Jung, Samantha Hanzel and John Neal

Chem. Proc. 2022, 6(1), 4; https://doi.org/10.3390/ECCS2021-11036 - 14 Oct 2021

Cited by 2 | Viewed by 1766

Abstract

An annulus type of photocatalytic reactor was designed, constructed, and characterized for its performance for the oxidation of ethanol and hexane vapors in air. The photocatalytic device utilized ultraviolet (λ = 365 nm) light-emitting diodes (UV-LEDs) as light sources and photocatalytic (Degussa P25 TiO₂) films coated on the inside surfaces of the reactor. These reactor systems can be applied to mobile and niche applications. UV-LEDs are small, robust light sources that require low direct current (DC) power, which could be provided by a battery. The study results demonstrate that the UV-LED-based photocatalytic system is capable of reducing or eliminating ethanol and hexane vapors in air. Test results have demonstrated the sensitivity of the effectiveness of the UV-LED-based photocatalytic system on operating parameters, including flow rate, concentration, type of VOC, humidity, and longevity. Full article

(This article belongs to the Proceedings of The 2nd International Electronic Conference on Catalysis Sciences—A Celebration of Catalysts 10th Anniversary)

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