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Search Results (4)

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Authors = José E. Menezes-Filho

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18 pages, 13665 KiB  
Article
Advances in Antitumor Effects Using Liposomal Citrinin in Induced Breast Cancer Model
by Michely Laiany Vieira Moura, Ag-Anne Pereira Melo de Menezes, José Williams Gomes de Oliveira Filho, Maria Luiza Lima Barreto do Nascimento, Antonielly Campinho dos Reis, Alessandra Braga Ribeiro, Felipe Cavalcanti Carneiro da Silva, Adriana Maria Viana Nunes, Hercília Maria Lins Rolim, Ana Amélia de Carvalho Melo Cavalcante and João Marcelo de Castro e Sousa
Pharmaceutics 2024, 16(2), 174; https://doi.org/10.3390/pharmaceutics16020174 - 26 Jan 2024
Cited by 1 | Viewed by 2044
Abstract
The study aimed to evaluate the antitumor and toxicogenetic effects of liposomal nanoformulations containing citrinin in animal breast carcinoma induced by 7,12-dimethylbenzanthracene (DMBA). Mus musculus virgin females were divided into six groups treated with (1) olive oil (10 mL/kg); (2) 7,12-DMBA (6 mg/kg); [...] Read more.
The study aimed to evaluate the antitumor and toxicogenetic effects of liposomal nanoformulations containing citrinin in animal breast carcinoma induced by 7,12-dimethylbenzanthracene (DMBA). Mus musculus virgin females were divided into six groups treated with (1) olive oil (10 mL/kg); (2) 7,12-DMBA (6 mg/kg); (3) citrinin, CIT (2 mg/kg), (4) cyclophosphamide, CPA (25 mg/kg), (5) liposomal citrinin, LP-CIT (2 μg/kg), and (6) LP-CIT (6 µg/kg). Metabolic, behavioral, hematological, biochemical, histopathological, and toxicogenetic tests were performed. DMBA and cyclophosphamide induced behavioral changes, not observed for free and liposomal citrinin. No hematological or biochemical changes were observed for LP-CIT. However, free citrinin reduced monocytes and caused hepatotoxicity. During treatment, significant differences were observed regarding the weight of the right and left breasts treated with DMBA compared to negative controls. Treatment with CPA, CIT, and LP-CIT reduced the weight of both breasts, with better results for liposomal citrinin. Furthermore, CPA, CIT, and LP-CIT presented genotoxic effects for tumor, blood, bone marrow, and liver cells, although less DNA damage was observed for LP-CIT compared to CIT and CPA. Healthy cell damage induced by LP-CIT was repaired during treatment, unlike CPA, which caused clastogenic effects. Thus, LP-CIT showed advantages for its use as a model of nanosystems for antitumor studies. Full article
(This article belongs to the Special Issue Frontiers in the Application of Nanomaterials in Drug Delivery)
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20 pages, 3204 KiB  
Article
Antibacterial Activity and Anxiolytic Effect in Adult Zebrafish of Genus Lippia L. Species
by Carla de Fatima Alves Nonato, Emerson Vinicius Silva de Melo, Cicera Janaine Camilo, Maria Kueirislene Amâncio Ferreira, Jane Eire Alencar de Meneses, Antonio Wlisses da Silva, Hélcio Silva dos Santos, Jaime Ribeiro-Filho, Joanda Paolla Raimundo e Silva, Josean Fechine Tavares, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Tomasz Baj, Radosław Kowalski and José Galberto Martins da Costa
Plants 2023, 12(8), 1675; https://doi.org/10.3390/plants12081675 - 17 Apr 2023
Cited by 8 | Viewed by 3134
Abstract
Species belonging to the genus Lippia are used worldwide as foods, beverages, and seasonings. Studies have demonstrated that these species have antioxidant, sedative, analgesic, anti-inflammatory, and antipyretic activities. This work aimed to evaluate the antibacterial activity and anxiolytic effect by different pathways of [...] Read more.
Species belonging to the genus Lippia are used worldwide as foods, beverages, and seasonings. Studies have demonstrated that these species have antioxidant, sedative, analgesic, anti-inflammatory, and antipyretic activities. This work aimed to evaluate the antibacterial activity and anxiolytic effect by different pathways of essential oils and ethanolic extracts of three species of Lippia (Lippia alba, Lippia sidoides, and Lippia gracilis). The ethanolic extracts were characterized by HPLC-DAD-ESI-MSn and their phenolics were quantified. The antibacterial activity was evaluated by determining the minimal inhibitory concentration and modulation of antibiotic activity, and toxic and anxiolytic effects were evaluated in the zebrafish model. The extracts showed compositions with a low ratio and shared compounds. L. alba and L. gracilis showed higher amounts of phenols and flavonoids, respectively. All extracts and essential oils presented antibacterial activity, especially those obtained from L. sidoides. On the other hand, L. alba extract presented the most significant antibiotic-enhancing effect. The samples were not toxic after 96 h of exposure, but showed an anxiolytic effect through modulation of the GABAA receptor, while L. alba extract acted via modulation of the 5-HT receptor. This new pharmacological evidence opens horizons for therapeutic approaches targeting anxiolytic and antibacterial therapies and food conservation using these species and their constituents. Full article
(This article belongs to the Special Issue Biosynthesis, Function, and Application of Plant Volatiles II)
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25 pages, 2519 KiB  
Article
Anti-Inflammatory and Physicochemical Characterization of the Croton rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin
by Anita Oliveira Brito Pereira Bezerra Martins, Almir Gonçalves Wanderley, Isabel Sousa Alcântara, Lindaiane Bezerra Rodrigues, Francisco Rafael Alves Santana Cesário, Maria Rayane Correia de Oliveira, Fyama Ferreira e Castro, Thaís Rodrigues de Albuquerque, Maria Sanadia Alexandre da Silva, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Paula Passos Menezes, Lucindo José Quintans-Júnior, Adriano Antunes de Souza Araújo, Marcello Iriti, Jackson Roberto Guedes da Silva Almeida and Irwin Rose Alencar de Menezes
Biology 2020, 9(6), 114; https://doi.org/10.3390/biology9060114 - 30 May 2020
Cited by 18 | Viewed by 4702
Abstract
Croton rhamnifolioides is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of C. rhamnifolioides essential oil complexed in β-cyclodextrin (COEFC). The physicochemical characterization of the complexes was performed [...] Read more.
Croton rhamnifolioides is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of C. rhamnifolioides essential oil complexed in β-cyclodextrin (COEFC). The physicochemical characterization of the complexes was performed using different physical methods. The anti-inflammatory activity was evaluated in vivo by ear edema, paw edema, cotton pellet-induced granuloma, and vascular permeability by Evans blue extravasation. The mechanism of action was validated by molecular docking of the major constituent into the cyclooxygenase-2 (COX-2 enzyme). All doses of the COEFC reduced acute paw edema induced by carrageenan and dextran, as well as vascular permeability. Our results suggest the lowest effective dose of all samples inhibited the response induced by histamine or arachidonic acid as well as the granuloma formation. The complexation process showed that the pharmacological effects were maintained, however, showing similar results using much lower doses. The results demonstrated an involvement of the inhibition of pathways dependent on eicosanoids and histamine. Complexation of β-cyclodextrin/Essential oil (β-CD/EO) may present an important tool in the study of new compounds for the development of anti-inflammatory drugs. Full article
(This article belongs to the Special Issue Natural Products in Modern Biology: Ancient Wisdom for Today’s Challenges)
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12 pages, 1902 KiB  
Article
The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels
by Ana C. N. Freitas, Steve Peigneur, Flávio H. P. Macedo, José E. Menezes-Filho, Paul Millns, Liciane F. Medeiros, Maria A. Arruda, Jader Cruz, Nicholas D. Holliday, Jan Tytgat, Gareth Hathway and Maria E. De Lima
Toxins 2018, 10(1), 43; https://doi.org/10.3390/toxins10010043 - 15 Jan 2018
Cited by 16 | Viewed by 7888
Abstract
The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin δ-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19 induces antinociception by activation of CB1, [...] Read more.
The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin δ-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19 induces antinociception by activation of CB1, μ and δ opioid receptors. Since the peripheral and central antinociception induced by PnPP-19 involves opioid activation, the aim of this work was to identify whether this synthetic peptide could directly activate opioid receptors and investigate the subtype selectivity for μ-, δ- and/or κ-opioid receptors. Furthermore, we also studied the modulation of calcium influx driven by PnPP-19 in dorsal root ganglion neurons, and analyzed whether this modulation was opioid-mediated. PnPP-19 selectively activates μ-opioid receptors inducing indirectly inhibition of calcium channels and hereby impairing calcium influx in dorsal root ganglion (DRG) neurons. Interestingly, notwithstanding the activation of opioid receptors, PnPP-19 does not induce β-arrestin2 recruitment. PnPP-19 is the first spider toxin derivative that, among opioid receptors, selectively activates μ-opioid receptors. The lack of β-arrestin2 recruitment highlights its potential for the design of new improved opioid agonists. Full article
(This article belongs to the Special Issue Toxins in Drug Discovery and Pharmacology)
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